1.A bibliometric and visual analysis of the literature published in the journal of Organ Transplantation since its inception
Xi CAO ; Tao HUANG ; Qiwei YANG ; Lin YU ; Xiaowen WANG ; Wenfeng ZHU ; Haoqi CHEN ; Ning FAN ; Genshu WANG
Organ Transplantation 2026;17(1):133-142
Objective To systematically analyze the literature characteristics of Journal of Organ Transplantation since its inception. Methods Using the China National Knowledge Infrastructure (CNKI) academic journal full-text database as the data source, all articles published in the Journal of Organ Transplantation from January 2010 to August 2025 were retrieved. After excluding non-academic papers, a total of 1 568 research papers were included. R language 4.3.0, Bibliometrix package 3.2.1, and Citespace software were used to analyze the number of publications, publishing institutions, authors, keywords and other aspects. Results The number of publications in Journal of Organ Transplantation increased from an average of 82 articles per year in the early years after its inception to 113 articles per year in recent years, a growth of 37.8%. The geographical distribution of publishing institutions covers 32 provinces, cities and autonomous regions nationwide, mainly concentrated in the South China, East China and North China regions, and has now basically covered the central and western regions in recent years. The author collaboration network includes 45 authors distributed across 7 major collaboration clusters, forming a stable multi-level national research system centered on key university-affiliated hospitals. The high-frequency keywords are dominated by "liver transplantation" (425 times) and "kidney transplantation" (396 times). The theme evolution shows a clear three-stage characteristic: initially focusing on clinical technology application, deepening to immune mechanism exploration in the middle stage, and recently (since 2022) focusing on cutting-edge research areas such as xenotransplantation. Conclusions Journal of Organ Transplantation has witnessed the rapid development of China's organ transplantation cause, fully reflecting the research status and trends in China's organ transplantation field, and has provided an important platform for the future development and international cooperation in China's organ transplantation field.
2.Construction of a family-centered care program for children with tuberculosis based on the double ABC-X model and intervention effects evaluation
Ning DONG ; Lei SHEN ; Yonghong TAO ; Yuanhao WU ; Xiaowen WEI ; Lin ZHANG
Shanghai Journal of Preventive Medicine 2025;37(2):184-189
ObjectiveTo construct a family-centered care model for children with tuberculosis based on the double ABC-X model, and to evaluate its clinical effects. MethodsFrom December 2022 to October 2023, 64 newly admitted children with tuberculosis who met the criteria and their caregivers were recruited from the tuberculosis department of Shanghai Public Health Clinical Center were randomly divided into an experimental group (32 cases) and a control group (32 cases).The control group was given a conventional health care, while the experimental group was given a family-centered health care intervention based on the double ABC-X model, in which a multidisciplinary care team provided personalized information and emotional support for the caregivers and their children. Medication adherence of the children, caregiver’s teading burden, and disease management competence were compared between the 2 groups. ResultsA total of 29 cases in the experimental group and 27 cases in the control group completed the intervention. At 12 weeks of intervention, the medication adherence score (7.72±0.45 vs 7.41±0.50, P<0.05) and disease management competence score (36.97±7.85 vs 31.56±7.30, P<0.05) were higher in the experimental group than that in the control group while the caregiving burden score (31.79±13.40 vs 40.04±9.01, P<0.05) and difficulty of disease management score (30.41±12.41 vs 38.56±9.48, P<0.05) were lower than that in the control group. At 24 weeks of intervention, the medication adherence score (7.34±0.97 vs 6.70±1.14, P<0.05) and disease management competence score (42.07±6.93 vs 35.63±7.32, P<0.05) were higher in the experimental group than that in the control group as well, but the caregiving burden score (31.62±11.72 vs 39.63±10.17, P<0.05) and difficulty of disease management score (30.59±10.87 vs 37.81±9.32, P<0.05) were lower than that in the control group. ConclusionFamily-centered care based on the double ABC-X model can effectively promote medication adherence among children with tuberculosis, reduce caregivers’ care burden and disease management difficulties, and improve caregiver’s disease management competence.
3.Prevalence and influencing factors of postpartum depression symptoms among elderly multipara
LIN Feiyun ; ZHOU Mincong ; CHEN Xiaowen
Journal of Preventive Medicine 2025;37(7):732-736
Objective:
To analyze the current status and influencing factors of postpartum depression symptoms among elderly multipara, so as to provide a basis for health management among elderly pregnant women.
Methods:
Multipara aged ≥35 years who underwent 42-day postpartum check-ups in Hangzhou Gynecology and Gynecology Hospital from October 2023 to October 2024 were selected as survey subjects using convenience sampling method. Demographic information, sleep quality and feeding methods data were collected using questionnaires. The postpartum depressive symptoms, parenting stress, and social support levels were assessed using the Chinese version of the Simplified Edinburgh Postnatal Depression Scale, Parenting Stress Inventory-Short Form, and Perceived Social Support Scale, respectively. Factors affecting postpartum depression symptoms among elderly multipara were analyzed through multivariable logistic regression model.
Results:
A total of 355 elderly multipara were surveyed. The average age was (38.19±2.10) years. There were 228 cesarean deliveries (64.23%) in this pregnancy. There were 21 cases (5.92%) of unplanned pregnancy and 21 cases (5.92%) of preterm birth. The parenting stress score was (72.56±11.08) points, and the social support score was (60.42±8.50) points. Postpartum depression symptoms was detected in 106 elderly multipara, with a detection rate of 29.86%. Multivariable logistic regression analysis showed that monthly household income per capita (≥5 000 yuan, OR=0.470, 95%CI: 0.281-0.785), unplanned pregnancy (yes, OR=2.619, 95%CI: 1.427-4.809), preterm delivery (yes,OR=4.105, 95%CI: 1.848-9.113), poor sleep quality (yes, OR=3.556, 95%CI: 1.659-7.595), feeding methods (mixed feeding, OR=1.483, 95%CI: 1.030-2.135; artificial feeding, OR=4.510, 95%CI: 2.018-10.070), parenting stress (OR=1.206, 95%CI: 1.162-1.441), and social support (OR=0.255, 95%CI: 0.111-0.420) were factors affecting postpartum depression symptoms among elderly multipara.
Conclusion
The detection rate of postpartum depression symptoms among elderly multiparas is relatively high, is associated with family economic status, pregnancy planning status, preterm delivery, sleep quality, feeding methods, parenting stress, and social support levels.
4.Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1.
Xiaowen LIN ; Lechen ZHAO ; Heng CAI ; Xiaohua CHANG ; Yuxuan TANG ; Tianyu LUO ; Mengdan WU ; Cuiying YI ; Limin MA ; Xiaojing CHU ; Shuo HAN ; Qiang ZHAO ; Beili WU ; Maozhou HE ; Ya ZHU
Protein & Cell 2025;16(5):381-385
5.Intolerance of uncertainty and internet addiction among college students: the mediating roles of negative cognitive bias and difficulties in emotion regulation
Yan LIN ; Xiaowen HOU ; Jingjing ZHANG ; Guohua ZHANG ; Bibing DAI
Chinese Journal of Behavioral Medicine and Brain Science 2024;33(6):527-531
Objective:To explore the relationship between intolerance of uncertainty and internet addiction among college students, as well as the mediating roles of negative cognitive bias and difficulties in emotion regulation.Methods:In September 2022, 1 762 college students were assessed with intolerance uncertainty scale, negative cognitive process bias questionnaire, difficulties in emotion regulation scale and internet addiction test. SPSS 24.0 software was used for descriptive statistics and correlation analysis. AMOS 23.0 was used to construct a multiple mediation model, and Bootstrap method was used for mediation effects testing.Results:(1) The score of intolerance of uncertainty was 34.00 (28.00, 40.00), the score of negative cognitive bias was 42.00 (34.00, 50.00), the score of difficulties in emotion regulation was 26.00 (20.00, 32.00), and the score of internet addiction was 36.00 (28.00, 46.00). (2)The Spearman correlation analysis showed that intolerance of uncertainty, negative cognitive bias, difficulties in emotion regulation, and internet addiction were significantly positively correlated with each other ( r=0.343-0.626, P<0.01). (3) The results of the path analysis indicated that the direct effect of intolerance of uncentainty on internet addiction was not significant, and the total indirect effect was 0.402(95% CI=0.354-0.451).The indirect effect of negative cognitive bias was 0.253(95% CI=0.200-0.305), accounted for 62.94%(0.253/0.402) of the total indirect effect.The indirect effect of difficulties in emotion regulation was 0.052 (95% CI=0.033-0.076), accounted for 12.93%(0.052/0.402) of the total indirect effect.And the chain mediating effect of negative cognitive bias and difficulties in emotion regulation was 0.097(95% CI=0.068-0.131), accounted for 24.13%(0.097/0.402) of the total indirect effect. Conclusion:Intolerance of uncertainty is significantly positively correlated with internet addiction, and its effects on internet addiction are individually mediated by negative cognitive bias and difficulties in emotion regulation, as well as their chain mediating effects.
6.Analysis on the development strategy of clinical research in children's specialized hospital based on SWOT model
Yuhui LIN ; Xiaowen CHEN ; Yingyan ZHENG ; Yongkai ZHU ; Pin JIA ; Rui DONG
Modern Hospital 2024;24(6):965-969
Objective To provide strategies and suggestions for the development of clinical research in children's spe-cialized hospitals.Methods With a Class A tertiary children's specialty hospital in Shanghai as an example,the SWOT model is used to analyze the strengths,weaknesses,opportunities,and threats of clinical research development in the hospital,and to propose corresponding strategies and suggestions.Results The hospital has distinguished disciplinary advantages,tremendous strength in scientific research,a strong team of talents,and steady progress in the construction of clinical research center.The weaknesses include imperfect clinical research management system,imperfect informatization construction,and insufficient allo-cation of full-time management personnel.There are now opportunities of high policy support,increasing funding support,the shift in clinical demand,and good prospects for development of investigator-initiated trials(IIT).The hospital is also faced with the threat of difficulty in conducting pediatric clinical research and fierce competition among similar hospitals.Conclusion We could promote the development of pediatric clinical research by incentivizing the conduction of clinical research,strengthening the construction of clinical research system,improving the clinical research capabilities,and building a collaborative network for ped-iatric multicenter clinical research.
7.Logics in scientific research management systems of public hospitals in the new era:connotations,principles and pathways
Jiayi WU ; Xianshan LIN ; Wanxia CHEN ; Xiaowen HUANG
Modern Hospital 2024;24(11):1655-1657
This paper explores the logic of scientific research management system of public hospitals in the new era,i-dentifying its connotations,principles,and pathways.From a value perspective,the system underscores the integration of effi-ciency and equity.In terms of governance logic,it advocates a shift from a single government-centric approach to a collaborative model that includes both government and market operation logics.The principles guiding transformation advocate for combination of ethical and market considerations,balance of rights and responsibilities,and integration of individual self-efficacy and organi-zational support.In terms of pathway selection,the paper proposes a comprehensive strategy that begins with forging a unified sci-entific research vision,serving as the foundation for creating a pedagogical organization to foster continuous learning,and the im-plementation of performance assessments based on core value.These strategies aim to modernize and enhance the efficiency of the scientific research management system in public hospitals.
8.Progress on prenatal and postnatal evaluation and management of antenatal hydronephrosis
Bingjie CHENG ; Lin HUANG ; Xiaowen WANG
International Journal of Pediatrics 2024;51(8):523-527
Antenatal hydronephrosis(AHN)is the most common congenital anomalies of kidney and urinary tract(CAKUT)detected through prenatal ultrasound screening.Approximately two-thirds of AHN are physiological and can be relieved spontaneously after birth,while AHN may be aggravated in some cases,resulting in deterioration of kidney function or severe complications and requiring surgical intervention.Currently,there is a lack of consensus on the prenatal and postnatal management of AHN,making it crucial to stratify the risk for affected children and establish appropriate follow-up plans.This article reviews the clinical assessment and management of AHN in prenatal and postnatal settings based on domestic and international literature,with the goal of raising AHN awareness among families of high-risk children and alleviating anxiety and excessive intervention for families of low-risk children,ultimately promoting individualized diagnosis and treatment.
9.Break the domestic public hospital clinical research evaluation system under the background of"five only"
Xiaowen CHEN ; Yongkai ZHU ; Yingyan ZHENG ; Yuhui LIN ; Peng SHI ; Liyuan HAN ; Pin JIA ; Rui DONG
Modern Hospital 2024;24(3):465-468,492
Objective The purpose of this article is to summarize and review the current status of the construction of clinical research evaluation systems in domestic public hospitals,identify existing problems in the evaluation system,and propose development strategies and suggestions.Methods Retrieved relevant articles,dissertations and policies from the past five years(2018-2022),screened the titles,viewed the full texts of 52 selected papers and their references,and summarized them.Results The"five-only"indicators have long been an important indicator for evaluating clinical research in public hospitals,but in today's scientific research environment and policy environment,the"five-only"evaluation system has revealed its utilitarian draw-backs and gradually evolved into a hindrance to scientific research.It is urgent to break through the"five-only"orientation and establish a clinical research evaluation system oriented towards"transforming and applying transformation of scientific research achievements".Conclusion The evaluation system for clinical research should break the previous"five-only"evaluation model based on quantity-oriented scientific research evaluation.We can draw on the framework of the research output,influence,and environment indicators in the UK's REF Excellence Framework model,combine the American APT system and the Chinese STEM indicator dimensions,explore multi-outcome evaluation,integrate developmental indicators,and continuously improve the indica-tor system and application methods in practice to promote the development of clinical research in public hospitals.
10.Investigation on major cognition and major choice motivation of medical freshmen
Lizhi LÜ ; Huangda GUO ; Xiaowen LIU ; Lin XU ; Yuxuan ZHAO ; Yan WANG ; Yawen JIA ; Yun WANG
Chinese Journal of Medical Education Research 2024;23(3):353-358
Objective:To understand the major cognition, major choice motivation and the relationship between the two of medical students, and provide references and suggestions for the selection of talents in various majors of medical schools and the effective development of enrollment work.Methods:This study selected undergraduates of Batch 2019 from Peking University Health Science Center as the survey objects, conducted a questionnaire survey on their major cognition, major choice motivation and influencing factors, and used principal component analysis and Spearman rank correlation analysis.Results:The study found that the major cognition scores of 640 undergraduates of Batch 2019 from Peking University Health Science Center were clinical medicine (3.24±0.89) > stomatology (2.89±1.00) > basic medicine (2.66±1.02) > pharmacy (2.54±0.97) > preventive medicine (2.29±0.93) > nursing medicine (2.21±0.99) > medical laboratory (1.98±0.95) > medical English (1.95±0.93). Six major motivation factors for professional choice were school and professional strength, professional learning and job prospects, own factors, Peking University sentiments and the influence of others, medical factors, school policies, and the contribution rates were 34.60%, 12.97%, 7.42%, 6.00%, 5.59% and 5.37%, respectively. Major cognition scores and major choice motivation factors were positively correlated with each other to some extent.Conclusions:At present, students' major cognition level of medical majors still has a large room for improvement, and the motivational factors of major choice are more complicated, among which "the school and professional strength" and "the prospects of study and work" are important factors. Medical schools should focus on strengthening major publicity, improving students' major cognition, attracting aspiring students to apply for medical majors from many aspects, and improving the training quality of medical professionals.


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