OBJECTIVE To provide standardized whole-process guidance on drug traceability codes for medical institutions in Sichuan province， ensuring medication safety and compliance with medical insurance supervision requirements. METHODS Based on evidence-based principles and expert consensus， Expert Consensus on Whole-process Management of Drug Traceability Codes in Medical Institutions of Sichuan Province （hereinafter referred to as the Consensus） was formulated through systematic literature review， field investigations， establishment of a multidisciplinary expert committee and multiple rounds of questionnare consultation via the modified Delphi method， and finalized through consensus meetings. RESULTS & CONCLUSIONS The Consensus clarifies key operating procedures for code verification， code assignment and code return， whole-process operational standards for drug warehouse acceptance and storage， drug warehouse outbound delivery and pharmacy acceptance check， drug distribution and dispensing in pharmacy and intravenous admixture center， medication administration in nursing units and examination departments， as well as drug return process. Key recommendations are proposed such as improving the core functions of the drug traceability system， unifying the hospital-wide traceability code database， strengthening the management of traceability codes for backup medications， establishing a management organization and institutional framework， and optimizing the architectural design and data governance requirements of the drug traceability system. The release of the Consensus will provide scientific， standardized and implementable practical guidelines for medical institutions of Sichuan province， helping to improve closed-loop management of the drug traceability system， strengthen medication safety and fulfil medical insurance fund supervision.

Recent research has presented emerging evidence of the involvement of intercellular communication, neuroplasticity, neuroinflammation, epigenetics and neural regeneration in the pathogenesis of mental disorders. Exosomes are nano-sized membrane vesicles secreted by different types of cells and contain a diverse suite of biomolecules including proteins, lipids, nucleic acids, especially micro-ribonucleic acid, and so on. Exosomes have been shown to play crucial roles in cell-to-cell communication and other pathophysiological processes because of their unique ability to carry biofunctional molecules. It may prove that exosomes are involved in the pathogenesis of psychiatric diseases. Moreover, recent findings have revealed that exosomes can be used as potential drug/gene carriers, therapeutic agents, and diagnostic tools. The purpose of this narrative literature review is to discuss the possible role of exosomes in mental disorders, providing strategies for further studies of exosomes as precision medicines and possible diagnostic biomarkers.

Recent research has presented emerging evidence of the involvement of intercellular communication, neuroplasticity, neuroinflammation, epigenetics and neural regeneration in the pathogenesis of mental disorders. Exosomes are nano-sized membrane vesicles secreted by different types of cells and contain a diverse suite of biomolecules including proteins, lipids, nucleic acids, especially micro-ribonucleic acid, and so on. Exosomes have been shown to play crucial roles in cell-to-cell communication and other pathophysiological processes because of their unique ability to carry biofunctional molecules. It may prove that exosomes are involved in the pathogenesis of psychiatric diseases. Moreover, recent findings have revealed that exosomes can be used as potential drug/gene carriers, therapeutic agents, and diagnostic tools. The purpose of this narrative literature review is to discuss the possible role of exosomes in mental disorders, providing strategies for further studies of exosomes as precision medicines and possible diagnostic biomarkers.

Objective To compare cortical bone screwing and Endobutton plating for the treatment of ankle joint fracture complicated with injury to the distal tibiofibular syndesmosis. Methods Fifty-eight pa-tients with ankle joint fracture and injury to the distal tibiofibular syndesmosis were treated at Department of Orthopedic Surgery, The Affiliated Hospital to Guangdong Medical University from January 2014 to June 2016. Half of them were treated by conventional cortical bone screwing. They were 16 males and 13 females with an average age of 43.2 ± 4.1 years. The other half were treated by Endobutton plating. They were 15 males and 14 females with an average age of 44.1 ± 3.9 years. The 2 groups were compared in terms of intraoperative bleed-ing, operation time, tibiofibular clear space ( TBCS ) , tibiofibular overlap ( TBOL ) , the American Orthopedic Foot Ankle Society (AOFAS) ankle-hindfoot scale and complications. Results The cortical bone screwing group needed significantly shorter operation time (63.4 ± 5.4 min) than the plating group (89.6 ± 6.2 min) ( P ＜0.05) . There were no significant differences between the 2 groups in intraoperative bleeding ( 68.9 ± 6.3 mL versus 67.4 ± 6.4 mL ) , TBCS ( 4.6 ± 0.3 mm versus 4.7 ± 0.3 mm) , TBOL ( 7.5 ± 0.4 mm versus 7.4 ± 0.4 mm ) , good to excellent rate by AOFAS score ( 72.4% versus 75.9%) , or rate of complications ( 6.9% versus 10.3%) ( P ＞ 0.05 ). Conclusion Since cortical bone screwing and Endobutton plating show no signifi-cant difference for the treatment of ankle joint fracture complicated with distal tibiofibular syndesmosis injury, a proper surgical procedure should be decided according to the specific conditions of the patient.