Objective:To observe the clinical efficacy of Xinyue Decoction combined with fluoxetine hydrochloride in the treatment of cognitive impairment of senile depression.Methods:A randomized controlled trial study was conducted. Totally 116 elderly patients with depression accompanied by cognitive impairment were set as observation subjects, and were divided into a control group and an experimental group using random number table method, with 58 patients in each. The control group received treatment with fluoxetine hydrochloride capsules, while the experimental group was administered Xinyue Decoction Granules in addition to the treatment regimen of the control group. The treatment lasted for 8 weeks for both groups. Comparison was made between the two groups regarding the changes in TCM syndrome scores. Hamilton Depression Scale (HAMD-24) was used to assess the degree of depression, and Montreal Cognitive Assessment (MoCA BJ) was used to assess cognitive ability; the serum levels of brain-derived neurotrophic factor (BDNF), IL-1β, IL-6 and TNF-α were detected by ELISA; the adverse reactions during treatment were observed and recorded, and the clinical efficacy was evaluated.Results:The total effective rate of TCM syndromes was 90.4% (47/52) in the experimental group and 75.5% (40/53) in the control group, with statistical significance ( χ2=4.11, P<0.05); the total effective rate of MoCA-BJ was 76.9% (40/52) in the experimental group and 58.5% (31/53) in the control group, with statistical significance ( χ2=4.61, P<0.05); the total effective rate of HAMD-24 was 88.5% (46/52) in the experimental group and 71.7% (38/53) in the control group, with statistical significance ( χ2=4.07, P<0.05). After treatment, the TCM syndrome score, HAMD-24 and MoCA-BJ scores of the experimental group were lower than those in the control group ( t=-3.51, -5.11, 2.39, P<0.01 or P<0.05); the level of serum BDNF [(10.49±1.76) ng/L vs. (9.61±1.85) ng/L, t=2.28] in the observation group was higher than that of the control group ( P<0.05), and the levels of IL-1β, IL-6 and TNF-α were lower than those in the control group ( t=-2.50, -2.46, -2.18, P<0.05). During the treatment, the incidence of adverse reactions was 5.77% (3/52) in the experimental group and 7.55% (4/53) in the control group, without statistical significance ( χ2=0.13, P>0.05). Conclusion:Xinyue Decoction combined with fluoxetine hydrochloride can reduce the degree of depression in elderly patients with cognitive impairment of depression, improve the cognitive ability of patients and clinical efficacy.

Objective To explore the clinical value of multi-slice spiral CT (MSCT) and serum inflammatory markers in diagnosis of acute appendicitis.Methods A total of 78 patients with acute appendicitis who were admitted in our hospital from November 2015 to November 2016 were included in the study.Different CT grading,postoperative pathological types (simple appendicitis,purulent appendicitis,gangrenous appendicitis),WBC count of different pathogenic bacteria (E.coli,P.aeruginosa,and K.pneumoniae),NEUT％,and CRP level were detected.Results With the increasing of CT grading,WBC count,NEUT％,and CRP level were gradually elevated (P ＜ 0.05).WBC count,NEUT％,and CRP level in patients with simple appendicitis were significantly less than those with purulent appendicitis,and gangrenous appendicitis.And above indicators of patients with purulent appendicitis were significantly less than those with gangrenous appendicitis,and the pathological type showed a significant difference (P ＜ 0.05).The WBC count,NEUT％,and CRP level among patients with different pathogenic bacteria showed no significant difference (P ＞ 0.05).Conclusion Dynamic monitoring of WBC count,NEUT％,and CRP level and MSCT examination can contribute to more accurate diagnosis of acute appendicitis and the estimation of condition.

Objective To explore the clinical value of multi-slice spiral CT (MSCT) and serum inflammatory markers in diagnosis of acute appendicitis.Methods A total of 78 patients with acute appendicitis who were admitted in our hospital from November 2015 to November 2016 were included in the study.Different CT grading,postoperative pathological types (simple appendicitis,purulent appendicitis,gangrenous appendicitis),WBC count of different pathogenic bacteria (E.coli,P.aeruginosa,and K.pneumoniae),NEUT％,and CRP level were detected.Results With the increasing of CT grading,WBC count,NEUT％,and CRP level were gradually elevated (P ＜ 0.05).WBC count,NEUT％,and CRP level in patients with simple appendicitis were significantly less than those with purulent appendicitis,and gangrenous appendicitis.And above indicators of patients with purulent appendicitis were significantly less than those with gangrenous appendicitis,and the pathological type showed a significant difference (P ＜ 0.05).The WBC count,NEUT％,and CRP level among patients with different pathogenic bacteria showed no significant difference (P ＞ 0.05).Conclusion Dynamic monitoring of WBC count,NEUT％,and CRP level and MSCT examination can contribute to more accurate diagnosis of acute appendicitis and the estimation of condition.

Objective To investigate the effects of monocyte chemoattractant protein-1 (MCP-1) on the migration of neural stem cells in vivo. Methods The brain injured rat model was established with cortical micro-injection of lipopolysaccharide in Sprague-Dawley rats. The tissue of brain was immunohistochemistrically stained to detect the expression of MCP-1 and nestin 3 d, 5 d, and 7 d after modeling. Results The expression of MCP-1 increased, and reached a peak 5 d after modeling. The nestin-positive cells was found in the lipopolysaccharide injected area 7 d after modeling. Conclusion MCP-1 may induce the endogenous neural stem cells migrate to lipopolysaccharide injection area in vivo.