To satisfy the growing healthcare demands of the public, it is essential to develop a public service platform for vaccination. This initiative aligns with national policies, optimizes resource allocation, innovates service models, enhances service efficiency, and reduces service costs. Drawing on relevant national policies and regulatory requirements, as well as the notable achievements and practical experiences gained through the exploration and innovation of vaccination service models across various regions, this paper proposes expert recommendations. It defines the essential components and functional specifications for public service platforms, focusing on public needs such as electronic vaccination record management, appointment management, the promotion of electronic vaccination certificates, vaccination certificate verification for school enrollment, vaccination site navigation, and science communication and public engagement. The recommendations aim to serve as a reference for the development of vaccination public service platforms nationwide.

To satisfy the growing healthcare demands of the public, it is essential to develop a public service platform for vaccination. This initiative aligns with national policies, optimizes resource allocation, innovates service models, enhances service efficiency, and reduces service costs. Drawing on relevant national policies and regulatory requirements, as well as the notable achievements and practical experiences gained through the exploration and innovation of vaccination service models across various regions, this paper proposes expert recommendations. It defines the essential components and functional specifications for public service platforms, focusing on public needs such as electronic vaccination record management, appointment management, the promotion of electronic vaccination certificates, vaccination certificate verification for school enrollment, vaccination site navigation, and science communication and public engagement. The recommendations aim to serve as a reference for the development of vaccination public service platforms nationwide.

Objective To prepare paclitaxel-natural borneol complex,and to explore the prescription and preparation process of paclitaxel-natural borneol complex drug-loaded submicroemulsion,and its in vitro anti-tumor effect.Methods The Paclitaxel-natural borneol complex was prepared by grinding method and identified by Fourier Transform infrared spectroscopy(FT-IR)and differential scanning calorimetry(DSC).The compound drug-loaded submicroemulsion was prepared using a two-step high-pressure emulsification method.The single-factor investigation and the orthogonal experimental design were applied to optimize the formulation and preparation process.MTT assay,cell cloning assay,and cell scratch assay were used to evaluate the effect of this preparation on HCT-116 cells.Results The infrared spectral absorption peaks of taxol-natural borneol complex at 3 312.76 cm-1 and 3 513.92 cm-1 disappeared,and DSC analysis showed that a new absorption peak of taxol-natural borneol complex appeared at 154.56 ℃,indicating that taxol be coupled with natural borneol to form a new complex.The optimal prescription was 0.44％active pharmaceutical ingredient[paclitaxel-natural borneol(1∶3)],10％medium chain triglyceride,3％emulsifier[egg yolk lecithin-Poloxam 188(1∶2)],2％glycerol,0.3％oleate.The optimal process was emulsification at 80 ℃,60 MPa high pressure homogenization 10 times.The half inhibitory concentration(IC50)was 0.75 μg·mL-1 by MTT asssy in cell.In the cell cloning assay,the scratch healing area of blank control group,paclitaxel raw material and paclitaxel/natural borneol submicroemulsion were(36.44±3.35)％,(13.59±9.28)％,(8.30±4.09)％,respectively.The results were statistically significant(P＜0.05).In the plate cloning experiment,the cell cloning rates of blank control group,paclitaxel bulk drug group and submicroemulsion group were(37.92±0.729)％,(9.16±1.335)％and(3.36±1.065)％,respectively,the differents were statistically significant(P＜0.05).Conclusion This submicroemulsion has reasonable prescription,feasible process and good stability.Cell experiments showed that the submicronemulision effectively inhibits the proliferation and migration of HCT-116 cells,suggesting its potential as a promising antitumor agent.

Objective:To provide references for further improving the oral health of Air Force pilots by investigating the periodontal health status and oral hygiene behavior of Air Force pilots.Methods:A total of 182 active-duty Air Force pilots who underwent physical examinations at the Air Force Medical Center were randomly selected for periodontal examination and oral hygiene behavior questionnaires survey. They were grouped by age (<35 years and ≥35 years), hometown (urban-originated and rural-originated), and aircraft type (fighter or other aircraft types like bomber, helicopter, transporter, and trainer).Results:Among the 182 Air Force pilots, the detection rate of gingival bleeding, dental calculus, periodontal pocket and loss of periodontal attachment was 86.81%, 75.27%, 6.59%, 9.89%, respectively. There was 82.42% of the pilots brushed their teeth at least twice a day, 35.16% used dental floss every day, 80.22% alternately used different toothpastes, and only 9.34% used toothpastes containing fluoride. There was 56.04% of the pilots brushed their teeth up and down, 8.24% brushed horizontally, 70.88% brushed their teeth for 2-3 min, and 53.30% smoked. In the past 6 months, 48.35% of the pilots had experienced gingival bleeding, but 67.58% had not undergone tooth cleaning treatment in the past 12 months. The detection rates of periodontal pockets, loss of periodontal attachment and the rates of flossing use in ≥35 years group were higher than those in <35 years group, with significant differences ( χ2=6.04, 4.68, 11.00, P=0.014, 0.031, 0.012), and there was also a significant difference in brushing method between the 2 groups ( χ2=17.75, P<0.001). There were significant differences in the detection rates of dental calculus, brushing frequency, brushing method, and the treatment of dental cleaning in the past 12 months between the rural-originated group and the urban-originated group ( χ2=6.25, 7.20, 13.81, 4.02, P=0.012, 0.007, 0.003, 0.045). The smoking rate in the fighter group was lower than that in the other aircraft types group, with significant difference ( χ2=10.10, P=0.018). Conclusions:The periodontal health status of Air Force pilots is still not optimistic, and the oral hygiene behavior still needs to be further improved. It is necessary to further strengthen oral hygiene education for pilots, improve their oral hygiene behavior, and enhance the support capabilities to their oral health.

Objective:To provide references for further improving the oral health of Air Force pilots by investigating the periodontal health status and oral hygiene behavior of Air Force pilots.Methods:A total of 182 active-duty Air Force pilots who underwent physical examinations at the Air Force Medical Center were randomly selected for periodontal examination and oral hygiene behavior questionnaires survey. They were grouped by age (<35 years and ≥35 years), hometown (urban-originated and rural-originated), and aircraft type (fighter or other aircraft types like bomber, helicopter, transporter, and trainer).Results:Among the 182 Air Force pilots, the detection rate of gingival bleeding, dental calculus, periodontal pocket and loss of periodontal attachment was 86.81%, 75.27%, 6.59%, 9.89%, respectively. There was 82.42% of the pilots brushed their teeth at least twice a day, 35.16% used dental floss every day, 80.22% alternately used different toothpastes, and only 9.34% used toothpastes containing fluoride. There was 56.04% of the pilots brushed their teeth up and down, 8.24% brushed horizontally, 70.88% brushed their teeth for 2-3 min, and 53.30% smoked. In the past 6 months, 48.35% of the pilots had experienced gingival bleeding, but 67.58% had not undergone tooth cleaning treatment in the past 12 months. The detection rates of periodontal pockets, loss of periodontal attachment and the rates of flossing use in ≥35 years group were higher than those in <35 years group, with significant differences ( χ2=6.04, 4.68, 11.00, P=0.014, 0.031, 0.012), and there was also a significant difference in brushing method between the 2 groups ( χ2=17.75, P<0.001). There were significant differences in the detection rates of dental calculus, brushing frequency, brushing method, and the treatment of dental cleaning in the past 12 months between the rural-originated group and the urban-originated group ( χ2=6.25, 7.20, 13.81, 4.02, P=0.012, 0.007, 0.003, 0.045). The smoking rate in the fighter group was lower than that in the other aircraft types group, with significant difference ( χ2=10.10, P=0.018). Conclusions:The periodontal health status of Air Force pilots is still not optimistic, and the oral hygiene behavior still needs to be further improved. It is necessary to further strengthen oral hygiene education for pilots, improve their oral hygiene behavior, and enhance the support capabilities to their oral health.

Objective    To evaluate the learning curve of CT-guided medical glue localization for pulmonary nodule before video-assisted thoracic surgery (VATS). Methods    The clinical data of the patients with pulmonary nodules who underwent CT-guided medical glue localization before VATS in our hospital from July 2018 to March 2021 were retrospectively analyzed. The patients were divided into 3 groups: a group A (from July 2018 to August 2019), a group B (from September 2019 to June 2020) and a group C (from July 2020 to March 2021). The localization time, morbidity, complete resection rate and other indexes were compared among the three groups. Results    A total of 77 patients were enrolled, including 24 males and 53 females aged 57.4±10.1 years. There were 25 patients in the group A, 21 patients in the group B, and 31 patients in the group C. 77 pulmonary nodules were localized. There was no significant difference among the groups in the basic data (P>0.05). The localization time in the group C was 10.6±2.0 min, which was statistically shorter than that in the group A (15.4±4.4 min) and group B (12.9±4.3 min) (P<0.01). The incidence of complications in the group C was lower than that in the group A and group B (25.8% vs. 52.0% vs. 47.6%, P=0.04). The success rate of localization of the three groups was not statistically different (P=0.12). Conclusion    There is a learning curve in CT-guided medical glue localization for single pulmonary nodule before VATS. After the first 46 cases, the operation time can be shortened, and the incidence of complications can be decreased.

Objective: To observe the clinical effect of acupuncture plus occupation therapy for fine motor functions in children with spastic cerebral palsy. Methods:A total of 80 cerebral palsy kids with fine motor dysfunction were allocated into two groups by envelop, 40 cases in each group. Cases in the control group were treated with occupation therapy. Based on the therapy given to the control group, cases in the treatment group were supplemented with acupuncture at the points of the three yang meridians of hand. The treatment was done every other day and 10 times for a course. There was a 15-day interval between two courses, and 3 courses in total. The therapeutic efficacies were evaluated using Peabody developmental motor scale 2 (PDMS-2) and modified Ashworth scale (MAS) before and after treatment. Results:After treatment, the standard score for grasping (Grs), standard score for visual-motor integration (Vis), fine motor quotient (FMQ) and modified Ashworth scale (MAS) were significantly improved in both groups (P<0.05). The improvement in the treatment group was more obvious than that in the control group (P<0.01). Conclusion:Acupuncture plus occupation therapy can achieve better effect than occupation therapy alone in improving fine motor functions of upper limbs in cerebral palsy kids.

Objective:To observe the clinical effect of Nie-pinching spine coupled with point application and injection for cerebral palsy (CP) in children with spleen deficiency.
Methods:A total of 70 CP children with spleen deficiency were randomly allocated into a treatment group (n=35) and a control group (n=35). Children in the treatment group were treated with comprehensive rehabilitation training, Nie-pinching spine, point application and point injection, whereas children in the control group were treated with comprehensive rehabilitation training and oral administration of multi-enzyme tablets. One course of treatment made up of 20 d. There was a 20-day interval between two courses. The cases were treated for a total of 3 courses. Then the therapeutic efficacies were evaluated using scores of spleen-deficiency symptoms and gross motor function measure (GMFM).
Results:After 3 courses of treatment, the total effective rates for spleen-deficiency symptoms and rehabilitation were 85.7% and 77.1% respectively in the treatment group, versus 51.4% and 57.1% respectively in the control group, showing statistical differences (bothP<0.05).
Conclusion:In addition to comprehensive rehabilitation training, Nie-pinching spine combined with point application and injection obtained better effects than oral administration of multi-enzyme tablets.

Objective:To explore the calvarial critical size defect (CSD)in rats with type 2 diabetes mellitus(T2DM).Methods:T2DM model of SD rats(weighted 300-320 g)was induced by high fat and high sugar diet and low dose intraperitoneal streptozotocin (STZ)injection.The rats with T2DMand the normal controls were divided into 4 groups(n=3)respectively.Defects with the diame-ter(mm)of 2,3,4 and 5 were made on the central calvaria of each rat.General observation,X-ray examination and histological study were performed 8 weeks postoperatively.Results:In the T2DM group,only the defects of 2 mm diameter were healed completely,X-ray resistance and new bone formation were observed;the defects of 3,4 and 5 mm diameter were unhealed,X-ray transmission was observed and newly formed bone was insufficient.In the control group,the defects of 2,3 and 4 mm diameter were healed completely, X-ray resistance and new bone formation were observed;the defects of 5 mm diameter were unhealed,X-ray transmission was ob-served,newly formed bone was insufficient.Conclusion:The calvarial CSD of T2DM rat model can be defined as the defect with the diameter of 3 mm.