Ethanol (EtOH) is a common trigger for gastric mucosal diseases, and mitigating oxidative stress is essential for attenuating gastric mucosal damage. Capsaicin (CAP) has been identified as a potential agent to counteract oxidative damage in the gastric mucosa; however, its precise mechanism remains unclear. This study demonstrates that CAP alleviates EtOH-induced gastric mucosal injuries through two primary pathways: by suppressing the chemokine receptor 4 (CCR4)/Src/p47phox axis, thereby reducing oxidative stress, and by inhibiting the phosphorylation and nuclear translocation of nuclear factor-κB p65 (NF-κB) p65, resulting in diminished inflammatory responses. These findings elucidate the mechanistic pathways of CAP and provide a theoretical foundation for its potential therapeutic application in the treatment of gastric mucosal injuries.
Ethanol/toxicity* ; Animals ; Gastric Mucosa/metabolism* ; Signal Transduction/drug effects* ; Oxidative Stress/drug effects* ; Capsaicin/pharmacology* ; Male ; NADPH Oxidases/genetics* ; Mice ; Humans ; src-Family Kinases/genetics*

Objective:To investigate the impact of regional innovation on medical security and its spatial effects across 31 provinces in China,providing scientific evidence for synergizing the"Healthy China"strategy with regional coordinated development.Methods:Based on provincial panel data from 2007 to 2023,the medical insurance fund expenditure was employed as a proxy for medical security.Methodologies include Moran's I tests,dual-way fixed effects models,Spatial Durbin Models(SDM)with adjacency and inverse-distance matrices,and spatial mediation models were applied to comprehensively analyze the direct effects,spatial spillover effects,and mediating pathways of regional innovation on medical security.Results:During the observation period,medical security levels in all provinces showed a fluctuating upward trend with significant regional disparities,where eastern provinces outperformed central and western regions.Regional innovation exhibited significant positive direct effects and spatial spillover effects on medical security.Regional innovation can improve medical insurance coverage by promoting growth in medical financial expenditure and the conversion of medical patents.Conclusion:Policy recommendations include deepening the synergy between regional innovation and medical security,optimizing the allocation of medical fiscal resources,accelerating the transformation of technological innovations,and narrowing regional development gaps.

Objective:Bioinformatics and experimental validation reveal the core genes of neutrophil extracellular traps(NETs)in chronic obstructive pulmonary disease(COPD).Methods:Chip data GSE8545,GSE10006,GSE11906,GSE19407 and GSE20257 were downloaded from GEO database,and the common differential expression genes(DEGs)of the first 4 datas were ob-tained through intersection and enrichment analysis were performed.Neutrophil extracellular traps differential expression genes(NETs-DEGs)were obtained by overlapping the NETs-related genes and the common DEGs,and GSE20257 was used to verify the NETs-DEGs and evaluate the diagnostic efficacy,and enrichment analysis was performed and mRNA expression level was verified in lung tissue of mice emphysema model.Results:A total of 149 common DEGs were acquired.DO analysis mainly concentrated in lung disease and COPD.GO functional annotation mainly involved in olefin metabolism,cytohormone metabolism,endoplasmic reticulum lumen,signaling receptors and oxidative stress activities.KEGG enrichment analysis mainly involved in cytochrome P450 metabo-lism,chemical carcinogenic reactive oxygen species,steroid hormone biosynthesis and phagosome,etc.GSE20257 dataset verifica-tion showed that NETs-DEGs TLR7 and CYP4F3 were up-regulated,and AUC values were 0.750 and 0.947.GO and KEGG mainly focused on fat-soluble vitamin catabolic signaling pathways,phagosomes,arachidonic acid monooxygenase activity,pattern recogni-tion receptors,arachidonic acid metabolism,Toll-like receptor signaling pathways and formation of NETs.Compared with air exposure group,mRNA expression levels of TLR7 and CYP4F3 in lung tissue of emphysema mice induced by cigarette smoke exposure were sig-nificantly increased(P<0.05).Conclusion:TLR7 and CYP4F3 may be the core genes in formation and release of NETs during the pathogenesis of COPD,which are expected to become the targets of immunotherapy for COPD.

Objective:To investigate the impact of regional innovation on medical security and its spatial effects across 31 provinces in China,providing scientific evidence for synergizing the"Healthy China"strategy with regional coordinated development.Methods:Based on provincial panel data from 2007 to 2023,the medical insurance fund expenditure was employed as a proxy for medical security.Methodologies include Moran's I tests,dual-way fixed effects models,Spatial Durbin Models(SDM)with adjacency and inverse-distance matrices,and spatial mediation models were applied to comprehensively analyze the direct effects,spatial spillover effects,and mediating pathways of regional innovation on medical security.Results:During the observation period,medical security levels in all provinces showed a fluctuating upward trend with significant regional disparities,where eastern provinces outperformed central and western regions.Regional innovation exhibited significant positive direct effects and spatial spillover effects on medical security.Regional innovation can improve medical insurance coverage by promoting growth in medical financial expenditure and the conversion of medical patents.Conclusion:Policy recommendations include deepening the synergy between regional innovation and medical security,optimizing the allocation of medical fiscal resources,accelerating the transformation of technological innovations,and narrowing regional development gaps.

Objective:Bioinformatics and experimental validation reveal the core genes of neutrophil extracellular traps(NETs)in chronic obstructive pulmonary disease(COPD).Methods:Chip data GSE8545,GSE10006,GSE11906,GSE19407 and GSE20257 were downloaded from GEO database,and the common differential expression genes(DEGs)of the first 4 datas were ob-tained through intersection and enrichment analysis were performed.Neutrophil extracellular traps differential expression genes(NETs-DEGs)were obtained by overlapping the NETs-related genes and the common DEGs,and GSE20257 was used to verify the NETs-DEGs and evaluate the diagnostic efficacy,and enrichment analysis was performed and mRNA expression level was verified in lung tissue of mice emphysema model.Results:A total of 149 common DEGs were acquired.DO analysis mainly concentrated in lung disease and COPD.GO functional annotation mainly involved in olefin metabolism,cytohormone metabolism,endoplasmic reticulum lumen,signaling receptors and oxidative stress activities.KEGG enrichment analysis mainly involved in cytochrome P450 metabo-lism,chemical carcinogenic reactive oxygen species,steroid hormone biosynthesis and phagosome,etc.GSE20257 dataset verifica-tion showed that NETs-DEGs TLR7 and CYP4F3 were up-regulated,and AUC values were 0.750 and 0.947.GO and KEGG mainly focused on fat-soluble vitamin catabolic signaling pathways,phagosomes,arachidonic acid monooxygenase activity,pattern recogni-tion receptors,arachidonic acid metabolism,Toll-like receptor signaling pathways and formation of NETs.Compared with air exposure group,mRNA expression levels of TLR7 and CYP4F3 in lung tissue of emphysema mice induced by cigarette smoke exposure were sig-nificantly increased(P<0.05).Conclusion:TLR7 and CYP4F3 may be the core genes in formation and release of NETs during the pathogenesis of COPD,which are expected to become the targets of immunotherapy for COPD.

Objective:To construct an indicator system to comprehensively evaluate the resource allocation level of the health and pension industry in 31 provinces of China from 2016 to 2021,calculate the fairness of resource allocation,clarify the problems in resource allocation of the health and pension industry in China,and promote high-quality development of the health and pension industry.Methods:The entropy method is used to comprehensively evaluate the level of resource allocation in the health care industry,and the Gini coefficient and Theil index are used to analyze the fairness of resource allocation in the health care industry.Results:The level of resource allocation in the health and pension industry is generally not high,with significant inter provincial differences;the unequal allocation of resources in the health industry is on the rise;regional differences are the leading force that causes differences in the fairness of resource allocation in the health and pension industry.Conclusion:It is suggested to improve the infrastructure and stimulate the endogenous impetus of the development of the health and pension industry;deeply cultivate market demand and improve the level of resource allocation in the health and pension industry;optimize financial investment and bridge the gap in regional health resource allocation.

Monkeypox is a zoonotic disease caused by monkeypox virus infection. This disease primarily occurs in tropical rainforest regions of central and western Africa, and is occasionally exported to other regions. Since May 2022, multinational monkeypox outbreak has become the largest monkeypox outbreak in history outside Africa. This review summarizes progress in the etiology, epidemiology, laboratory detection, clinical diagnosis and treatment of monkeypox.

Objective:To analyze the influencing factors of quality of life in patients with inflammatory bowel disease (IBD) , especially the effect of disease acceptance on quality of life.Methods:A cross-sectional study was conducted to select 244 IBD patients diagnosed in the First Affiliated Hospital of Air Force Medical University from January to October 2020 by convenience sampling. The general information questionnaire, Chinese version of illness acceptance scale (AIS-CHI) and inflammatory bowel disease quality of life (IBDQ) were used to collect the data of patients. Univariate analysis was used to compare the differences of quality of life in IBD patients with different characteristics. Factors with statistical significance in univariate analysis were included in multiple linear regression analysis to determine the independent influencing factors. Pearson correlation was used to analyze the correlation between quality of life and disease acceptance in IBD patients.Results:The quality of life score of IBD patients was (173.71 ± 33.52) points, which was at a low level. The disease acceptance score was (22.32 ± 7.34) points, which was at a moderate and low level. Univariate analysis showed that there were significant differences in quality of life score between the patients with different education levels, personalities, monthly incomes, acceptances of disease and disease activities (all P<0.05) . Multiple linear regression analysis showed that disease acceptance and disease activity were independent influencing factors of quality of life. Disease acceptance was positively correlated with the quality of life ( b = 2.625, t = 10.477, P<0.001) , and disease activity was negatively correlated with the quality of life ( b = -5.559, t = -2.645, P = 0.009) . Pearson correlation analysis showed that acceptance of disease was positively correlated with quality of life ( r = 0.293, P<0.001) , and acceptance of disease was positively correlated with many dimensions of quality of life including intestinal function, systemic symptoms, emotional function and social function (all P<0.05) . Conclusions:Disease activity and disease acceptance can independently affect the quality of life of patients with IBD. The higher the disease acceptance, the lower the disease activity, and the higher the quality of life of patients.

Objective:To analyze the influencing factors of quality of life in patients with inflammatory bowel disease (IBD) , especially the effect of disease acceptance on quality of life.Methods:A cross-sectional study was conducted to select 244 IBD patients diagnosed in the First Affiliated Hospital of Air Force Medical University from January to October 2020 by convenience sampling. The general information questionnaire, Chinese version of illness acceptance scale (AIS-CHI) and inflammatory bowel disease quality of life (IBDQ) were used to collect the data of patients. Univariate analysis was used to compare the differences of quality of life in IBD patients with different characteristics. Factors with statistical significance in univariate analysis were included in multiple linear regression analysis to determine the independent influencing factors. Pearson correlation was used to analyze the correlation between quality of life and disease acceptance in IBD patients.Results:The quality of life score of IBD patients was (173.71 ± 33.52) points, which was at a low level. The disease acceptance score was (22.32 ± 7.34) points, which was at a moderate and low level. Univariate analysis showed that there were significant differences in quality of life score between the patients with different education levels, personalities, monthly incomes, acceptances of disease and disease activities (all P<0.05) . Multiple linear regression analysis showed that disease acceptance and disease activity were independent influencing factors of quality of life. Disease acceptance was positively correlated with the quality of life ( b = 2.625, t = 10.477, P<0.001) , and disease activity was negatively correlated with the quality of life ( b = -5.559, t = -2.645, P = 0.009) . Pearson correlation analysis showed that acceptance of disease was positively correlated with quality of life ( r = 0.293, P<0.001) , and acceptance of disease was positively correlated with many dimensions of quality of life including intestinal function, systemic symptoms, emotional function and social function (all P<0.05) . Conclusions:Disease activity and disease acceptance can independently affect the quality of life of patients with IBD. The higher the disease acceptance, the lower the disease activity, and the higher the quality of life of patients.