Objective To explore the effects of non-invasive mechanical ventilation combined with caf-feine citrate treatment on newborn respiratory distress syndrome(NRDS).Methods A total of 120 infantile patients with NRDS treated in this hospital from February 2021 to February 2023 were selected and divided into the two groups by using the random number table method,60 cases in each group.The control group re-ceived the non-invasive mechanical ventilation treatment,while the experimental group received the non-inva-sive mechanical ventilation combined with caffeine citrate treatment.The clinical improvement statuses inclu-ding the mechanical ventilation usage rate,pulmonary surfactant(PS)superaddition rate,mechanical ventila-tion time,oxygen therapy time and hospitalization time,meanwhile the blood gas analysis indicators before and after treatment[blood pH value,oxygen partial pressure(PaO2),carbon dioxide partial pressure(PaCO2)],in-flammatory markers[nuclear factor-kappa B(NF-κB),procalcitonin(PCT),interferon-gamma(IFN-γ),in-terleukin-6(IL-6),IL-10],myocardial injury and oxidative stress markers[creatine kinase isoenzyme(CK-MB),superoxide dismutase(SOD),malondialdehyde(MDA)]and the incidence rates of complications(vomi-ting,abdominal distension,nasal mucosa injury,necrotizing enterocolitis(NEC)and bronchopulmonary dys-plasia)were compared between the two groups.Results Compared to the control group,the mechanical venti-lation time,oxygen therapy time and hospitalization time in the experimental group were significantly de-creased(P＜0.05).After treatment,the blood oxygen partial pressure(PaO2)and blood pH values were in-creased,and the carbon dioxide partial pressure(PaCO2)was decreased(P＜0.05).The levels of inflammato-ry markers NF-κB,PCT,IFN-γ and IL-6 were decreased,while the IL-10 level was increased(P＜0.05).The myocardial injury index CK-MB was decreased and the oxidative stress index SOD level was increased and MDA level was decreased(P＜0.05).The incidence rate of complications in the experimental group was low-er than that in the control group,but the difference was not statistically significant(P＞0.05).Conclusion Non-in-vasive ventilation combined with caffeine citrate in treating NRDS could improve the clinical status,blood gas indexes and reduce the inflammation and myocardial injury of the infantile patients,which is worthy of clinical promotion and application.

Objective:To explore the team construction and treatment strategy of the Diabetic Foot-Multidisciplinary Team.Methods:The clinical data of 19 patients with severe ischemic diabetic foot treated by our Diabetic Foot-Multidisciplinary Team Center from Apr 2021 to Mar 2022 were collected, and the overall amputation rate, above-ankle major amputation rate, minor amputation rate and mortality, Diabetic Foot-Multidisciplinary Team consultation discipline participation rate and treatment participation degree were retrospectively analyzed.Results:Nineteen patients (15 males and 4 females) were enrolled, aged 26 to 94 (68.6±14.2). All were with severe ischemic diabetic foot ulcer:Rutherford grade 5 or up and dysfunction in 2 or more organs. Complications included arteriosclerosis obliterans of the lower extremities in 18 cases, heart diseases in 18, hypertension in 15, and renal insufficiencies in 10. The overall amputation rate was 36.8%, major amputation rate in 21.1%, minor amputation rate in 15.8%, and mortality rate was 15.8%. A total of 16 disciplines participated in Diabetic Foot-Multidisciplinary Team; the main participating disciplines were vascular surgery (19 times), endocrinology (12 times), and cardiology (11 times). The main treatment disciplines were vascular surgery (14 times), plastic surgery (3 times), and cardiology (2 times).Conclusion:For the diagnosis and treatment of diabetic foot, it is necessary to set up a multidisciplinary team as early as possible to control the causes of diabetic foot ulcer, prevent the recurrence of diabetic foot ulcer, reduce the mortality and amputation rate, and improve the quality of life of patients.