[Objective] To analyze the prognostic value of prostate cancer (PCa) pyroptosis-related genes (PRGs) using gene expression databases and to explore the regulatory mechanism of nucleotidebinding oligomerization domain-like receptor containing pyrin domain 1 (NLRP1) in the pyroptosis of PCa cells. [Methods] Fragments per kilobase of exon model per million reads mapped (FPKM) data and clinical information from PCa and adjacent tissues from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were obtained. Differentially expressed PRGs between PCa and adjacent tissues, classified subtypes and plotted survival curves were analyzed. Univariate Cox regression analysis, least absolute shrinkage and selection operator (LASSO) regression analysis were conducted to screen prognosis-related PRGs, risk scores were calculated, and a prognostic risk model was constructed and validated. Patients were divided into high and low risk groups based on the median risk scores from the training and validation sets, and gene ontology (GO) enrichment and kyoto encyclopedia of genes and genomes (KEGG) analysis were conducted on differentially expressed PRGs. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of NLRP1 in PCa cell lines, and pyroptosis was induced in DU145 and LNCaP cells while morphological changes were observed. Western blot (WB) was performed to detect the expression of pyroptosis-related molecules. [Results] A total of 6 prognostic-related PRGs were obtained, including CHMP4C, CYCS, GPX4, GSDMB, NLRP1, and PLCG1. The risk score was positively correlated with the risk of recurrence but negatively correlated with the progression-free survival (P<0.001). The area under the receiver operating characteristic curves (AUCs) for the training set at 1, 3, and 5 years were 0.769 (95%CI: 0.652-0.878), 0.804 (95%CI: 0.736-0.882), and 0.772 (95%CI: 0.631-0.905), respectively, while those for the validation set were 0.731 (95%CI: 0.647-0.826), 0.753 (95%CI: 0.674-0.818), and 0.763 (95%CI: 0.626-0.849), respectively. Differences in expression levels of the 6 PRGs were observed between the high and low risk groups in both the training and validation sets (P<0.05). Cox regression analysis showed that T stage, prostate specific antigen (PSA), Gleason grade, and risk score were independent predictors of PCa prognosis (P<0.05). Differences in risk scores were observed among patients of different ages, T stages, and Gleason grades (P<0.05). NLRP1 was found to be lowly expressed in PCa cell lines and was involved in the regulation of pyroptosis in DU145 and LNCaP cells. [Conclusion] The prognostic risk model constructed based on PRGs has a certain predictability for the prognosis of PCa patients, and NLRP1 may be involved in the regulation of pyroptosis in PCa cells.

Neutrophils as the first immune responders to infection can quickly identify and eliminate pathogens. The mainly rely on glycolysis to exert their killing functions. Although researches on the metabolic shifs that affect neutrophil functions began early, little is known about how neutrophils undergo metabolic transformation during the anti-infection process. It has been proven that glycogen metabolism plays an important role in regulating the functions of neutrophils. Other metabolic pathways besides glycolysis, such as mitochondrial metabolism and fatty acid oxidation during neutrophil differentiation, have potential contributions to the regulation of neutrophils′ functions. This review summaries current studies about metabolic regulatory effects of neutrophils on anti-infection responses, intending to provide reference for further study on the metabolism of neutrophils.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.

The modernisation of Chinese-style all-round and full-cycle health service system is an important guarantee to meet the growing health needs of the residents,and it is also a necessary way to promote the construction of a healthy China and achieve universal health coverage.Through literature and logical analysis and other research methods,on the basis of analysing the connotation and characteristics of the modernisation of the Chinese-style comprehensive and full-cycle health service system,the following optimisation progression is proposed:(1)policy leadership-constructing a comprehensive policy system and building a solid health cornerstone;(2)science and technology empowerment-strengthening the application of scientific and technological innovation to drive the development of health;(3)service upgrading-improving the quality of the service process to optimize the health experience;(4)conceptual innovation-changing the traditional concept of health and improving health literacy.