Objective: To investigate the self-monitoring blood pressure behavior and its influencing factors among residents in Jiangsu Province, so as to provide the basis for strengthening proactive blood pressure monitoring among residents. Methods: Permanent residents aged 35-75 years in six counties (cities, districts), Jiangsu Province, were selected using the stratified cluster sampling method in 2023. Data on basic information, disease history, and self-monitoring blood pressure behavior were collected, height and weight were measured to calculate the body mass index (BMI); and blood glucose and lipid levels were measured. Self-monitoring blood pressure behavior was defined as having measured blood pressure at least once in the past three months. Factors affecting self-monitoring blood pressure behavior were identified using a multivariable logistic regression model. Results: A total of 12 475 residents were surveyed, including 5 748 males and 6 727 females, with a male-to-female ratio of 1∶1.17. There were 3 855 residents aged 45-<55 years (30.90%) and 5 511 residents who had self-monitoring blood pressure behaviors (44.18%). Multivariable logistic regression analysis showed that the residents who were males (OR=1.167, 95%CI: 1.081-1.261), lived in rural areas (OR=1.430, 95%CI: 1.321-1.547), aged 45-75 years (45-<55 years, OR=1.384, 95%CI: 1.241-1.543; 55-<65 years, OR=1.397, 95%CI: 1.243-1.570; 65-75 years, OR=1.196, 95%CI: 1.049-1.363), had an annual household income ≥30 000 yuan (30 000-<60 000 yuan, OR=1.190, 95%CI: 1.072-1.321; 60 000-<110 000 yuan, OR=1.330, 95%CI: 1.191-1.485; ≥110 000 yuan, OR=1.746, 95%CI: 1.536-1.984), were overweight (OR=1.170, 95%CI: 1.070-1.280) or obese (OR=1.248, 95%CI: 1.120-1.391), were unaware (OR=1.221, 95%CI: 1.103-1.353) or aware (OR=3.937, 95%CI: 3.575-4.335) of having hypertension, were aware of having diabetes (OR=1.538, 95%CI: 1.354-1.749), and aware of having dyslipidemia (OR=1.265, 95%CI: 1.106-1.447) were more likely to have self-monitoring blood pressure behaviors. Conclusions Among the residents aged 35-75 years in Jiangsu Province, 44.18% had self-monitoring blood pressure behavior. Gender, place of residence, age, annual household income, BMI, hypertension, diabetes, and dyslipidemia were identified as influencing factors for self-monitoring blood pressure behavior.

Objective:To investigate the relationship between social interaction and emotional experience in older adults,and the moderating effects of social interaction objects and personality traits on their relationship.M-ethod:Totally 208 elderly individuals were selected and assessed with a self-designed demographic information questionnaire and the NEO Personality Inventory(NEOPI).The Rochester Interaction Record(RIR)was used to record 14 days of social activity,and the Positive-Negative Affect Scale(PANAS)was used to evaluate emotions after each interaction.Using Mplus Multilevel Model(MLM)for model construction.Results:Through model con-struction,it was found that the interaction between openness and communication quality was statistically significant(β=0.45,P＜0.05).When the dependent variable was positive emotion,the higher the openness of elderly people,the stronger the connection between communication quality and positive emotion.When interacting with non-family members,the interaction between openness and social quality was statistically significant(β=0.52,P＜0.05).The higher the openness of older adults,the stronger the connection between social quality and positive emotions.Conclusion:It suggests that older adults with moderate or higher levels of openness have a stronger con-nection between social interaction quality and positive emotions when interacting with non-family members.That is,the higher the quality of interaction,the more positive emotions could be promoted,but negative emotions could not be reduced.

Objective To analyze the mortality rate and trend of chronic obstructive pulmonary disease(COPD)among residents in Sichuan Province from 2011 to 2023.Methods The collected mortality monitoring data of residents from 2011 to 2023 were analyzed using Joinpoint regression the trend of COPD mortality rate in Sichuan Province from 2011 to 2023.Based on the COPD mortality rate data of residents from 2011 to 2023 to established an autoregressive integrated moving average method(ARIMA)to predict the trend of mortality rate changes.Results From 2011 to 2023,the crude mortality rate of males was 79.74/100,000,which was higher than that of females(64.82/105),and the standardized mortality rate of males(48.02/105)was higher than that of females(40.51/105)(P<0.05).From 2011 to 2023,the annual percentage change(APC)of male mortality rate and female mortality rate were-4.51% and-5.59%(P<0.05),and the APC of standardized mortality rate of male and female were-9.35%,and-9.91%,with a significant downward trend(P<0.05).From 2011 to 2023,the COPD mortality rates of residents aged 45～54,55～64,65～74 and≥75 years in Sichuan Province were-12.04%,-10.88%,-13.87% and-7.19%,respectively,and with an obvious downward trend in different age groups(P<0.05).The crude mortality rate of COPD in urban decreased from 100.67/105 to 52.93/105,and APC of the crude mortality rate was-5.71%;while the crude mortality rate of rural residents decreased from 86.13/105 to 60.10/105,and APC of the crude mortality rate was-3.69%,with an obvious downward trend(P<0.05%).The standardized COPD mortality rate of urban residents in Sichuan Province from 2011 to 2023 decreased from 79.13/105 to 24.09/105,and APC of the standardizedmortality rate was-10.09%;while the rural residents decreased from83.99/105 to 31.58/105,and APCwas-7.98%,with an obvious downward trend(P<0.05%).The ARIMA model was used to fit the COPD mortality rate in Sichuan Province in 2011～2023,and the COPD mortality rates in Sichuan Province in 2024～2028 were predicted to be 53.49/105,49.28/105,46.11/105,42.59/105 and 41.68/105,respectively.Conclusion The mortality rate of COPD among residents in Sichuan Province showed a downward trend from 2011 to 2023,with rural,male,and elderly populations being high-risk groups for COPD mortality.The ARIMA model had certain reference value for short-term prediction of COPD mortality rate.

Objective To explore the mechanism of electroacupuncture in alleviating hyperlipidemia in a rat model by modulating mammalian target of rapamycin complex 1(mTORC1)-mediated lipophagy in hepatocytes.Methods A total of 30 SD rats were randomly divided into blank(n=6)and modeling groups(n=24)using the random number table method.A hyperlipidemic rat model was established by feeding rats a high-fat diet(feeding for 8 weeks).After successful modeling,the modeling group was randomly divided into the model,electroacupuncture,mTORC1 inhibitor,and electroacupuncture+mTORC1 agonist groups,with six rats in each group.Except for the blank group,all other rats were fed with high fat diet.Rats in the electroacupuncture and electroacupuncture+mTORC1 agonist groups received electroacupuncture intervention at bilateral"Fenglong"(ST40)acupoints(dilatational wave 2 Hz/100 Hz,current intensity 1 mA)for 30 min once daily.Rats in the mTORC1 inhibitor group received intraperitoneal injections of the mTORC1 inhibitor,rapamycin(2 mg/kg),once daily.Rats in the electroacupuncture+mTORC1 agonist group received intraperitoneal injections of the mTORC1 agonist MHY1485(10 mg/kg)once daily.The interventions were administered for five consecutive days per week for 4 weeks.Upon completion of the intervention,the following analyses were performed:serum contents of total cholesterol(TC),triglycerides(TAG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),free fatty acids(FFA),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)were measured using a fully automated biochemical analyzer.Hepatic histopathological changes and lipid deposition were observed using hematoxylin-eosin and oil red O staining.The liver condition was observed and the liver index was calculated.Hepatic TC and TAG levels were measured using an enzyme-linked immunosorbent assay.The ultrastructure of the liver tissue was observed using transmission electron microscopy,and the mean fluorescence intensity of perilipin 2(PLIN2)and microtubule-associated protein 1 light chain 3(LC3)-Ⅱ in the liver tissue was detected using immunofluorescence.Protein expression of LC3-Ⅱ/LC3-Ⅰ,phosphorylated mammalian target of rapamycin(p-mTOR)/mTOR,and mTORC1 in liver tissue was detected using Western blotting.Results Compared to the blank group,the model group rats showed increased serum TC,TAG,LDL-C,ALT,AST,and FFA levels,along with decreased HDL-C levels(P<0.05).The liver index and hepatic TC and TAG levels were also elevated(P<0.05).Histological examination of liver tissue revealed substantial lipid accumulation,numerous lipid droplets within hepatocytes,abnormal mitochondrial morphology,and scarce autophagic vacuole.The mean fluorescence intensity of PLIN2 increased,whereas that of LC3-Ⅱ decreased(P<0.05).Additionally,the LC3-Ⅱ/LC3-Ⅰ ratio was reduced,whereas the p-mTOR/mTOR ratio and mTORC1 protein expression were increased(P<0.05).Compared to the model group,rats in the mTORC1 inhibitor and electroacupuncture groups exhibited decreased serum TC,TAG,LDL-C,ALT,AST,and FFA levels(P<0.05),along with a reduced liver index and hepatic TC and TAG levels(P<0.05).Histological examination showed markedly attenuated lipid accumulation and visible autophagic vacuole in the hepatocytes.The mean fluorescence intensity of PLIN2 decreased,whereas that of LC3-Ⅱ increased(P<0.05).Moreover,the LC3-Ⅱ/LC3-Ⅰ ratio increased,whereas the p-mTOR/mTOR ratio and mTORC1 protein expression decreased(P<0.05).In comparison with both the electroacupuncture and mTORC1 inhibitor groups,the electroacupuncture+mTORC1 agonist group demonstrated increased serum TAG,TC,LDL-C,ALT,AST,and FFA levels(P<0.05)as well as elevated liver index and hepatic TC and TAG levels(P<0.05).Liver tissues exhibited aggravated lipid deposition and absence of autophagic vacuole in liver cells.The mean fluorescence intensity of PLIN2 was enhanced,whereas that of LC3-Ⅱ was reduced(P<0.05).Furthermore,the LC3-Ⅱ/LC3-Ⅰ ratio decreased,and the p-mTOR/mTOR ratio and mTORC1 protein expression increased(P<0.05).Conclusion Electroacupuncture at"Fenglong"(ST40)may improve blood lipid levels in hyperlipidemic rats by inhibiting mTORC1 and promoting hepatocyte lipophagy.

Purpose Based on multimodal imaging combined with a variety of histological techniques,to visually evaluate the changes of rats brain metabolic microenvironment after cerebral hypoxia and ischemia of prematurity,and to discuss the effects of abnormal lactate metabolism in the brain on oligodendrocyte precursor cells,so as to provide a basis for the early diagnosis and treatment of premature white matter injury(PWMI).Materials and Methods A total of 36 SPF-grade healthy 3-day-old Sprague-Dawley neonatal rats were randomly assigned to the sham surgery(Sham)group and the model(PWMI)group using a random number table method,with 18 rats in each group.A neonatal rat PWMI model was established by hypoxia-ischemia method.Twenty-four hours after modeling,laser speckle imaging was used to monitor cerebral blood flow and blood oxygen changes.Multimodal imaging was used to observe the changes in brain tissue microstructure and metabolism after PWMI.HE staining was used to observe the morphological changes of nerve cells in the white matter of the brain.Enzyme-linked immunosorbent assay was used to detect the changes of lactate content and lactate dehydrogenase activity in the white matter region of the brain after PWMI in neonatal rats.PDGFR-α immunofluorescence staining was used to observe the dynamic changes of the number of oligodendrocyte precursor cells in the subependymal zone after PWMI in neonatal rats.Results Twenty-four hours after modeling,the multimodal imaging results showed that the T2WI and diffusion-weighted imaging on the injured side of the PWMI group showed high intensity,and the relative cerebral blood flow,relative oxygen saturation,relative apparent diffusion coefficient and amide proton transfer(APT)Lorentzian difference value were lower than those in the Sham group(t=29.466,23.522,59.006,54.778,10.263,all P<0.001),and the lactate content was higher than that in the Sham group(t=-7.521,P<0.001).The results of HE staining and enzyme-linked immunosorbent assay showed that the arrangement of nerve cells in the white matter area of the injured side of the brain in the PWMI group was loose and disordered.The lactate content and lactate dehydrogenase activity were higher than those in the Sham group(t=-6.079,-10.548,both P<0.001).The results of immunofluorescence staining showed that the number of PDGFR-α+cells in the subependymal zone of the damaged side of the PWMI group was higher than that of the Sham group at 24 hours after modeling,and lower than that in the Sham group at 11 days after modeling(t=-8.386,6.676,both P<0.001).The correlation analysis between the lactate content and APT Lorentzian difference value in the brain and the number of oligodendrocyte precursor cells in the brain 11 days after modeling showed that the number of oligodendrocyte precursor cells in the subependymal zone was positively correlated with the APT Lorentzian difference value(r=0.821,P=0.001 1),and negatively correlated with the lactate content in the brain(r=-0.880,P=0.000 2).Conclusion Multimodal imaging can monitor the early brain metabolism changes of PWMI in neonatal rats,especially the changes of lactate,and provide a visual basis for their early diagnosis.The level of lactate in the brain increases after cerebral hypoxia and ischemia in prematurity,and oligodendrocyte precursor cells increase transiently and then decrease,resulting in PWMI.

Cancer-associated venous thromboembolism(CAT)refers to the presence of venous thromboem-bolism including deep vein thrombosis and pulmonary embolism in patients with malignant cancer.Studies have indicated that CAT has become the second leading cause of death among cancer patients.Similar to other methods used to prevent and treat venous thromboembolism,anticoagulation remains to be the primary approach for CAT.However,the occurrence of CAT is influenced by various factors such as tumor type,staging,complications,treat-ment,and prognosis.This complexity makes the prevention and management of CAT more difficult and challeng-ing.This article reviews the classification of commonly used anticoagulant drugs in clinical practice,emphasizing the current status and advancements in their application for the prevention and treatment of cancer-related venous thromboembolism in order to provide valuable reference for clinical medication.

Objective To investigate the correlation between CT imaging features and histopathology invasive behaviors in isoat-tenuating and rim-enhancing pancreatic cancer.Methods A retrospective analysis was conducted on the CT imaging,clinical,and pathological data from 34 patients with atypical pancreatic cancer imaging appearances.All patients underwent surgical resection for diagnostic confirmation.Based on contrast attenuation,all cases were divided into isoattenuating group(13 cases)and rim-enhancing group(21 cases).The CT imaging and pathological characteristics of the two groups of lesions were analyzed.Results Significant differences were observed between the isoattenuating group and the rim-enhancing group in terms of lesion location,CT size,presence of necrosis or cystic changes,and common bile duct amputation/dilation.Pathological parameters,including pathological size,patho-logical grade,and T stage,also showed significant variation between the two groups(P＜0.05).No significant differences were found between the two groups in terms of gender,age,main pancreatic duct amputation/dilation,pancreatic parenchymal atrophy,vascular invasion,fat infiltration,nerve invasion,N stage,metastasis,and CA199 value(P＞0.05).Conclusion Isoattenuating pancreatic cancer and rim-enhancing pancreatic cancer,which display distinct contrast attenuation patterns,may exhibit different clinical and pathological characteristics,with potential implications for diagnostic and therapeutic strategies.

In recent years, fibroblast activation protein inhibitor (FAPI) PET imaging, which targets the tumor microenvironment, has shown significant potential in evaluating solid tumors. Particularly, studies have demonstrated the value of 68Ga-FAPI PET in evaluation of gastric and colorectal cancer. This article reviews previous studies and provides an overview of how 68Ga-FAPI PET can be used in the diagnosis, staging, recurrence monitoring, clinical management, efficacy evaluation, and prognostic prediction of gastric and colorectal cancer, in order to provide a basis for the further utilization of this novel imaging agent, 68Ga-FAPI, in gastric and colorectal cancer.

Objective:To determine if preoperative 68Ga-fibroblast activation protein inhibitor (FAPI)-04 PET/MR could contribute to predicting pathological complete response (pCR) in patients with gastrointestinal cancer undergoing neoadjuvant immunotherapy. Methods:In this retrospective study, 35 patients (23 males, 12 females, age (59.1±7.9) years) with gastrointestinal cancer who underwent 68Ga-FAPI-04 PET/MR after receiving neoadjuvant immunotherapy between February 2021 and January 2024 were enrolled. Clinical data, PET imaging parameters including SUV, peak of SUV normalized by lean body mass (SUL peak), FAPI-positive tumor volume (FTV), and total FAPI-positive lesion burden (TLF), and pathological data were collected and analyzed. Patients were divided into pCR group and non-pCR group, and the independent-sample t test or Mann-Whitney U test was performed to compare those parameters between the 2 groups. ROC curve analysis (Delong test) was performed to evaluate the diagnostic efficiency of each parameter to predict pCR. Results:The overall pCR rate of the neoadjuvant therapy was 40.0%(14/35). In the visual evaluation, 68Ga-FAPI-04 PET was limited in predicting pCR, showing false positivity in 12 patients and false negative in 1 patent. While SUV max( t=2.50, P=0.018), SUL peak( t=3.11, P=0.004), FTV( U=3.00, P=0.030) and TLF( U=2.96, P=0.042) in non-pCR group were all higher than those in pCR group. The predictive efficiency of FTV <1.925cm 3 for pCR was better than the efficiency of PET visual evaluation ( Z=3.61, P<0.001), with the prediction accuracy of 82.86%(29/35). Conclusions:68Ga-FAPI-04 PET/MR may provide an effective clinical tool for guiding further treatment of patients with gastrointestinal cancer undergoing neoadjuvant immunotherapy. The quantitative features derived from 68Ga-FAPI-04 PET appear promising in predicting pCR, which are expected to provide a reference for avoiding surgery.

In recent years, the convergent media environment, which integrates text, video, audio, animation, and other media forms, has become indispensable in higher education. Online teaching within this environment leverages a " cloud-based, multi-screen" dissemination model, effectively integrating various forms of media resources to accommodate mobile and ubiquitous learning scenarios. This approach meets the diverse needs of different learners, and makes course content delivery more dynamic while enhancing teacher-student interaction. As a result, it fosters innovation in course instruction, shifting teaching methods from " standardization" to " differentiation" , thereby providing a platform and resources for personalized learning. This paper analyzes the design and resource development strategies for Nuclear Medicine online courses within the convergent media environment from three perspectives: constructing a high-quality online course system centered on learning outcomes, driving innovation in online teaching focused on the learning experience, and highlighting the efficacy of cultivating high-quality nuclear medicine professionals through a top-tier online course. By systematically summarizing the implementation experience in building the Nuclear Medicine online course, this article aims to provide strategies and pathways to enrich the content supply and cross-platform integration of online medical courses in China.