Pulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes. Pulpotomy is categorized into partial pulpotomy (PP), the removal of a partial segment of the coronal pulp tissue, and full pulpotomy (FP), the removal of whole coronal pulp, which is followed by applying the biomaterials onto the remaining pulp tissue and ultimately restoring the tooth. Procedural decisions for the amount of pulp tissue removal or retention depend on the diagnostic of pulp vitality, the overall treatment plan, the patient's general health status, and pulp inflammation reassessment during operation. This statement represents the consensus of an expert committee convened by the Society of Cariology and Endodontics, Chinese Stomatological Association. It addresses the current evidence to support the application of pulpotomy as a potential alternative to root canal treatment (RCT) on mature permanent teeth with pulpitis from a biological basis, the development of capping biomaterial, and the diagnostic considerations to evidence-based medicine. This expert statement intends to provide a clinical protocol of pulpotomy, which facilitates practitioners in choosing the optimal procedure and increasing their confidence in this rapidly evolving field.
Humans ; Calcium Compounds/therapeutic use* ; Consensus ; Dental Pulp ; Dentition, Permanent ; Oxides/therapeutic use* ; Pulpitis/therapy* ; Pulpotomy/standards*

Intentional tooth replantation (ITR) is an advanced treatment modality and the procedure of last resort for preserving teeth with inaccessible endodontic or resorptive lesions. ITR is defined as the deliberate extraction of a tooth; evaluation of the root surface, endodontic manipulation, and repair; and placement of the tooth back into its original socket. Case reports, case series, cohort studies, and randomized controlled trials have demonstrated the efficacy of ITR in the retention of natural teeth that are untreatable or difficult to manage with root canal treatment or endodontic microsurgery. However, variations in clinical protocols for ITR exist due to the empirical nature of the original protocols and rapid advancements in the field of oral biology and dental materials. This heterogeneity in protocols may cause confusion among dental practitioners; therefore, guidelines and considerations for ITR should be explicated. This expert consensus discusses the biological foundation of ITR, the available clinical protocols and current status of ITR in treating teeth with refractory apical periodontitis or anatomical aberration, and the main complications of this treatment, aiming to refine the clinical management of ITR in accordance with the progress of basic research and clinical studies; the findings suggest that ITR may become a more consistent evidence-based option in dental treatment.
Humans ; Tooth Replantation/methods* ; Consensus ; Periapical Periodontitis/surgery*

Lipids play an important role in the regulation of cell life processes. Although there are various lipid detection methods, Raman spectroscopy, a non-invasive technique, provides the detailed chemical composition of lipid profiles without a complex sample preparation procedure and possesses greater potential in basic biology, clinical diagnosis and disease therapy. In this review, we summarized the characteristics and advantages of Raman-based techniques and their primary contribution to illustrating cellular lipid metabolism.

The development of multi-campus districts has become an important initiative for the country to expand high-quality medical resources and build a high-quality and efficient medical and healthcare service system,and is an important implementation path for the high-quality development of public hospitals.The symbiosis theory is highly applicable to multi-campus hospital development,and can provide a new perspective for the exploration of multi-campus hospital collaborative development.Through the construction of the symbiotic framework based on symbiotic unit,symbiotic interface,symbiotic environment and symbiotic model,it analyzed the symbiotic dilemma of multi-campus hospital collaborative development,and proposed the path of multi-campus hospital collaborative development,in order to provide reference for the subsequent construction and development of multi-campus hospital in China.

The development of multi-campus districts has become an important initiative for the country to expand high-quality medical resources and build a high-quality and efficient medical and healthcare service system,and is an important implementation path for the high-quality development of public hospitals.The symbiosis theory is highly applicable to multi-campus hospital development,and can provide a new perspective for the exploration of multi-campus hospital collaborative development.Through the construction of the symbiotic framework based on symbiotic unit,symbiotic interface,symbiotic environment and symbiotic model,it analyzed the symbiotic dilemma of multi-campus hospital collaborative development,and proposed the path of multi-campus hospital collaborative development,in order to provide reference for the subsequent construction and development of multi-campus hospital in China.

The development of multi-campus districts has become an important initiative for the country to expand high-quality medical resources and build a high-quality and efficient medical and healthcare service system,and is an important implementation path for the high-quality development of public hospitals.The symbiosis theory is highly applicable to multi-campus hospital development,and can provide a new perspective for the exploration of multi-campus hospital collaborative development.Through the construction of the symbiotic framework based on symbiotic unit,symbiotic interface,symbiotic environment and symbiotic model,it analyzed the symbiotic dilemma of multi-campus hospital collaborative development,and proposed the path of multi-campus hospital collaborative development,in order to provide reference for the subsequent construction and development of multi-campus hospital in China.

The development of multi-campus districts has become an important initiative for the country to expand high-quality medical resources and build a high-quality and efficient medical and healthcare service system,and is an important implementation path for the high-quality development of public hospitals.The symbiosis theory is highly applicable to multi-campus hospital development,and can provide a new perspective for the exploration of multi-campus hospital collaborative development.Through the construction of the symbiotic framework based on symbiotic unit,symbiotic interface,symbiotic environment and symbiotic model,it analyzed the symbiotic dilemma of multi-campus hospital collaborative development,and proposed the path of multi-campus hospital collaborative development,in order to provide reference for the subsequent construction and development of multi-campus hospital in China.

The development of multi-campus districts has become an important initiative for the country to expand high-quality medical resources and build a high-quality and efficient medical and healthcare service system,and is an important implementation path for the high-quality development of public hospitals.The symbiosis theory is highly applicable to multi-campus hospital development,and can provide a new perspective for the exploration of multi-campus hospital collaborative development.Through the construction of the symbiotic framework based on symbiotic unit,symbiotic interface,symbiotic environment and symbiotic model,it analyzed the symbiotic dilemma of multi-campus hospital collaborative development,and proposed the path of multi-campus hospital collaborative development,in order to provide reference for the subsequent construction and development of multi-campus hospital in China.

The development of multi-campus districts has become an important initiative for the country to expand high-quality medical resources and build a high-quality and efficient medical and healthcare service system,and is an important implementation path for the high-quality development of public hospitals.The symbiosis theory is highly applicable to multi-campus hospital development,and can provide a new perspective for the exploration of multi-campus hospital collaborative development.Through the construction of the symbiotic framework based on symbiotic unit,symbiotic interface,symbiotic environment and symbiotic model,it analyzed the symbiotic dilemma of multi-campus hospital collaborative development,and proposed the path of multi-campus hospital collaborative development,in order to provide reference for the subsequent construction and development of multi-campus hospital in China.

Objective:To explore the clinical characteristics and pathogenic variant in a child with Cantú syndrome (CS).Methods:A male who was admitted to the Children′s Hospital Affiliated to Zhengzhou University on February 23, 2022 was selected as the study subject. Clinical data of the child was collected. Peripheral blood samples of the child and his parents were collected and subjected to whole-exome sequencing (WES). Candidate variant was verified by Sanger sequencing. This study was approved by Medical Ethics Committee of the Children′s Hospital Affiliated to Zhengzhou University (Ethics No. 2023-K-087).Results:The child, a 3-year-and-2-month-old male, was born with hirsutism, with heavy hair all over the body and peculiar facial features. Routine echocardiography 1 month before had discovered atrial septal defect. Sequencing revealed that the child has harbored a heterozygous c. 2438G>C (p.S813T) variant of the ABCC9 gene, which was de novo in origin. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), the c. 2438G>C variant was classified as likely pathogenic (PS2+ PM2_Supporting+ PP3). Conclusion:The heterozygous c. 2438G>C variant of the ABCC9 gene probably underlay the pathogenesis of CS in this child.