Premature ovarian insufficiency(POI)refers to a condition in women where ovarian function declines prematurely before the age of 40,leading to disruptions in the menstrual cycle and impaired fertility.Professor He Chengyao,based on the theory of yin and yang,formulates the theory of nourishing essence and fostering ovarian function,and accordingly invented a distinctive gynecological formula for menstrual regulation.This formula is designed to modulate the menstrual cycle and augment the pregnancy rate.Professor He is adept at treating female reproductive system disorders from the perspective of fundamental physiology and also attaches significant importance to syndrome differentiation of the internal organs.Based on Professor He's clinical syndrome differentiation and treatment methodology,this article explored the pathogenic mechanism of premature ovarian insufficiency and accomplished flexible syndrome differentiation and treatment for this disorder.

Premature ovarian insufficiency(POI)refers to a condition in women where ovarian function declines prematurely before the age of 40,leading to disruptions in the menstrual cycle and impaired fertility.Professor He Chengyao,based on the theory of yin and yang,formulates the theory of nourishing essence and fostering ovarian function,and accordingly invented a distinctive gynecological formula for menstrual regulation.This formula is designed to modulate the menstrual cycle and augment the pregnancy rate.Professor He is adept at treating female reproductive system disorders from the perspective of fundamental physiology and also attaches significant importance to syndrome differentiation of the internal organs.Based on Professor He's clinical syndrome differentiation and treatment methodology,this article explored the pathogenic mechanism of premature ovarian insufficiency and accomplished flexible syndrome differentiation and treatment for this disorder.

OBJECTIVE:To observe the effect of ulinastatin on the serum inflammatory cytokines of patients with ulcerative colitis. METHODS:Totally 60 patients with ulcerative colitis were randomly divided into observation group and test group,and an-other 20 healthy volunteers were selected as normal control group. Test group were received routine treatment,including nutrition support and maintaining water,electrolyte balance and 5-amino salicylic acid (5-ASA),etc. Patients in observation group were treated by ulinastatin 200 000 U by intravenous infusion based on the treatment of test group,q12h. 7 d were as a course for the pa-tients,and it lasted for 2 courses. The clinical data in healthy control group and other 2 groups was observed,including tumor ne-crosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-8,C-reactive protein(CRP)levels,colon peroxidase activity(MPO),clinical activity index(CAI)scores and the incidence of adverse reactions before and after treatment. RESULTS:Before and after treatment, the TNF-α,IL-1β,IL-8,CRP and MPO in other 2 groups were significantly higher than health control group,with significant dif-ferences(P<0.05). After treatment,the TNF-α and IL-1β in 2 groups and the IL-8 and CRP levels in observation group were low than before,and the TNF-α,IL-8 and CRP levels in observation group were significantly lower than test group,with significant dif-ferences(P<0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Based on the routine treatment, ulinastatin can effectively inhibit the expression of inflammatory cytokines of patients with ulcerative colitis,and relieve the inflam-mation and injury of colon,with good safety.