Objective:To analyze the impact of dual-career healthcare professionals marital conflict styles patterns on each other′s work engagement and the underlying mechanisms, so as to provide empirical evidence for hospital managers to improve employee support systems.Methods:Based on the work-family resources model and social interdependence theory, an actor-partner interdependence model (APIM) was constructed. A three-stage questionnaire survey was conducted in March 2022 among 203 pairs of dual-career healthcare professionals to obtain data on the independent variable (conflict resolution pattern), the mediating variable (work-family balance), and the dependent variable (work engagement). Structural equation modeling and the Bootstrap method were used to conduct path analysis and mediating effect tests.Results:The aggressive marital conflict resolution pattern had a significant negative impact on the work engagement of healthcare couples themselves ( P<0.05). The appeasement conflict resolution pattern of husbands and wives had a positive impact on the work engagement of husbands ( P<0.05); however, the appeasement conflict resolution pattern of wives had a negative impact on their own work engagement ( P<0.05). The avoidance conflict resolution pattern of husbands had a negative impact on their own work engagement ( P<0.05). Through the examination of the interdependent mediating variable of work-family balance, 14 significant interdependent mediating paths were identified. In the aggressive marital conflict resolution pattern, the interdependent mediating role of work-family balance for both husbands and wives was established. In the avoidance marital conflict resolution pattern, the interdependent mediating role of work-family balance was partially established for both husbands and wives. Conclusions:The marital conflict resolution patterns of dual-career healthcare professionals had a significant interdependent mechanism in influencing each other′s work engagement. In particular, aggressive and avoidance conflict resolution patterns weaken work-family balance, thereby reducing the work engagement levels of both individuals and their spouses. It is recommended that hospital management departments strengthen conflict management training and family support measures to promote employees′ work-family coordination and professional engagement.

Objective:To analyze the impact of dual-career healthcare professionals marital conflict styles patterns on each other′s work engagement and the underlying mechanisms, so as to provide empirical evidence for hospital managers to improve employee support systems.Methods:Based on the work-family resources model and social interdependence theory, an actor-partner interdependence model (APIM) was constructed. A three-stage questionnaire survey was conducted in March 2022 among 203 pairs of dual-career healthcare professionals to obtain data on the independent variable (conflict resolution pattern), the mediating variable (work-family balance), and the dependent variable (work engagement). Structural equation modeling and the Bootstrap method were used to conduct path analysis and mediating effect tests.Results:The aggressive marital conflict resolution pattern had a significant negative impact on the work engagement of healthcare couples themselves ( P<0.05). The appeasement conflict resolution pattern of husbands and wives had a positive impact on the work engagement of husbands ( P<0.05); however, the appeasement conflict resolution pattern of wives had a negative impact on their own work engagement ( P<0.05). The avoidance conflict resolution pattern of husbands had a negative impact on their own work engagement ( P<0.05). Through the examination of the interdependent mediating variable of work-family balance, 14 significant interdependent mediating paths were identified. In the aggressive marital conflict resolution pattern, the interdependent mediating role of work-family balance for both husbands and wives was established. In the avoidance marital conflict resolution pattern, the interdependent mediating role of work-family balance was partially established for both husbands and wives. Conclusions:The marital conflict resolution patterns of dual-career healthcare professionals had a significant interdependent mechanism in influencing each other′s work engagement. In particular, aggressive and avoidance conflict resolution patterns weaken work-family balance, thereby reducing the work engagement levels of both individuals and their spouses. It is recommended that hospital management departments strengthen conflict management training and family support measures to promote employees′ work-family coordination and professional engagement.

Aim To investigate the sedative and hyp-notic effects of a novel compound H057 . Methods The sedative activity of H057 was investigated by re-cording the spontaneous locomotor activity in mice. The hypnotic property was evaluated by the latency and duration of loss of righting reflex( LORR) in mice and effect of H057 on the sleep onset in subthreshold dos-age of sodium pentobarbital treated mice. The extracel-lular levels of GABA and monoamine neurotransmitters in in cerebral cortex were measured by microdialysis in vivo. Results The spontaneous locomotor activity was decreased by 25% and 66% in H057 ( 5 , 25 mg · kg-1 ,i. p. ) treated mice, respectively. H057 ( 3, 5 mg·kg-1 ,i. p. ) increased the sleep onset to 62. 5%and 87. 5% in subthreshold dosage of sodium pentobar-bital(25 mg·kg-1,i. p. ) treated mice. H057(≥60 mg· kg-1 , i. p. ) could completely induce LORR in mice. The latency of LORR at dose of 60 mg · kg-1 was (24 ± 11) min and the duration of LORR was (96 ± 15 ) min. In vivo mircodialysis revealed that H057 (25 mg·kg-1 , i. p. ) could significantly increase the GABA level by 26% and decrease the 5-HT and NE levels by 50% and 38% in cerebral cortex in mice. Conclusion H057 has potent sedative and hypnotic effects, which may be closely related to the increased content of GABA and the decreased contents of 5-HT and NE in the extracellular fluid in cerebral cortex.

Objective To compare the similarities and differences between the esophageal mucosa lesion pathology before and after endoscopic submucosal dissection (ESD).Methods A total of 110 patients diagnosed as having esophageal mucosal lesions by endoscopic biopsy were treated with ESD at Zhejiang cancer hospital from 2013 to 2014.The results of preoperative and postoperative pathology were compared.Results The consistency rate of preoperative biopsy and postoperative pathologic diagnosis was 61.8％ (68/110).Compared with preoperative pathology,the postoperative pathological results underestimated accounted for 30％ (33/110),the postoperative pathological results overestimated accounted for 8.2％ (9/110).In early esophageal cancer group,consistency rate of preoperative biopsy and postoperative pathologic diagnosis was 75.0％ (18/24),which was higher than that of intraepithelial neoplasia group[58.1％ (50/86)] with significant difference (P ＜ 0.05).Conclusion Preoperative biopsy is not necessarily consistent with postoperative pathology.Though preoperative pathological diagnosis has certain value,it can not completely represent the nature of the lesions.The patients with intraepithelial neoplasia should be actively treated with ESD combined with clinical experiences to get the accurate diagnosis.

Objective To compare HC video-laryngoscope with Macintosh laryngoscope for tracheal intubation.Methods Sixty ASA Ⅰ or Ⅱ patients of both sexes,aged 18-64 yr,with body mass index 19-27 kg/m2,Mallampati grade Ⅰ-Ⅱ,undergoing elective surgery,were randomly divided into 2 groups (n =30 each):HC video-laryngoscope group (group H) and Macintosh laryngoscope (group M).After induction of anesthesia,the patients underwent orotracheal intubation assisted by HC video-laryngoscope in group H,and by Macintosh laryngoscope in group M.The glottic exposure time,intubation time,Cormack-Lehane grade,the number of pressing the cricoid and intubation-related complications were recorded.Results The rate of satisfactory glottic exposure was significantly higher and the number of pressing the cricoid was smaller in group H than in group M (P ＜ 0.05).There was no significant difference in the glottic exposure time,intubation time and incidence of intubation-related complications between the two groups (P ＞ 0.05).Conclusion The efficacy of tracheal intubation guided by HC video-laryngoscope is better than that guided by Macintosh laryngoscope.

ObjectiveTo compare the neuromuscular blockade induced by different target effect-site concentrations (Ces) of rocuronium in female patients.MethodsOne hundred and twenty ASA Ⅰ or Ⅱ female patients,aged 40-55 yr,with body mass index 18-22 kg/m2,scheduled for elective thyroid or breast surgery under general anesthesia,were included in the study.Anesthesia was induced with midazolam 0.1 mg/kg and fentanyl 5 μg/kg.Target-controlled infusion of rocuronium was started to facilitate tracheal intubation as soon as the patients lost consciousness.The patients were randomly divided into 4 groups ( n =30 each):A,B,C and D groups.In groups A,B,and C,the target Ce of rocuronium was set at 3.5 μg/ml during induction of anesthesia and at 1.0,1.2 and 1.4 μg/ml respectively during maintenance of anesthesia.In group D,the target Ce of rocuronium was set at 3.8 μg/ml during induction of anesthesia and at 1.2 μg/ml during maintenance of anesthesia.The onset time (time from the beginning of target-controlled infusion of rocuronium to T1 =5％ of the control twitch),recovery time (when T1 retumed to 25 ％ of the control twitch),recovery index (the time for Tt to return from 25 ％ to 75 ％of the control twitch),and the total amount of rocuronium consumed during operation were recorded.The intubation conditions and degree of muscle relaxation during operation were assessed.ResultsNeuromuscular block during operation was significantly better and the rate of satisfactory neuromuscular block was significantly higher in groups B,C and D than in group A ( P ＜ 0.05).Onset time was significantly shorter in group D than in groups A,B and C ( P ＜ 0.05).Compared with group C,the total amount of rocuronium consumed during operation,recovery time and recovery index were significantly decreased in groups A,B and D ( P ＜ 0.05).There was no significant difference in the total amount of rocuronium consumed during operation,recovery time and recovery index between groups B and D (P ＞0.05).ConclusionRocuronium with the target Ce set at 3.8 and 1.2 μg/ml during induction of anesthesia and mainterance of anesthesia respectively can provide satisfactory neuromuscular block,is helpful to the recovery of neuromuscular block and is more suitable for female patients.