Objective To establish a prognostic model that predicts the survival and prognosis of gastric adenocarcinoma patients by studying the LncRNAs related to iron death in gastric cancer cells,thereby providing a theoretical basis for the development of their biomarkers and therapeutic targets.Methods The transcript sequencing data of gastric adenocarcinoma patients in the TCGA database were analyzed and intersected with iron death-related genes,which were screened for iron death-related LncRNAs by co-expression and differential analysis methods.One-way and multifactorial Cox regression analyses were used to screen out the prognostic-related LncRNAs in gastric adenocarcinoma patients,so as to establish the prognostic scoring models.On this basis,risk values were calculated for each sample,and the reliability of the model was fully verified.According to the model results,differences in the immune infiltration and immune response between the high-and low-risk groups were analyzed.Results Tumor tissues were screened for 503 LncRNAs(431 up-regulated and 72 down-regulated)associated with iron death compared to the normal tissues;univariate Cox regression analysis yielded 33 LncRNAs that could be used as the independent risk factors,whereas multivariate Cox regression analysis constructed a predictive model consisting of 17 LncRNAs.Survival curves indicated that patients with the high risk had the significantly lower survival rates than those with the low risk(P<0.001).Unifactorial and multifactorial independent prognostic analyses showed that age,stage,and risk value were independent risk factors for patients;Time-dependent ROC curves suggested that the predicted AUC values of the model's 1-,2-,and 3-year survival rates were 0.751,0.799,and 0.779 respectively,proving that the model was reliable and stable.There were significant differences in multiple immune activation responses,the degree of immune cell infiltration,and the expression levels of immune check points between the high-and low-risk groups.Conclusion The established prognostic prediction model based on iron death-related lncRNAs for gastric adenocarcinoma patients can better assess the prognosis of patients,and the lncRNAs included in the model have the feasibility of being developed into biomarkers and therapeutic targets.

A 70-year-old female patient presented with fatigue and edema for 3 months and was found to have elevated serum creatinine for 3 weeks. During the course of the disease, she had fever and cough. Examinations revealed multiple ground-glass opacities in both lungs and positivity for myeloperoxidase-anti-neutrophil cytoplasmic antibodies (ANCA), leading to a diagnosis of ANCA-associated vasculitis. The patient′s condition initially improved after pulse glucocorticoid therapy combined with cyclophosphamide. During treatment, however, the patient developed hematochezia, and colonoscopy revealed multiple colonic ulcers. Immunohistochemistry of colonic mucosal biopsy confirmed cytomegalovirus (CMV) positivity, establishing a diagnosis of CMV colitis. The patient was found to have concurrent Clostridioidesdifficile and pulmonary infections. During the disease course, the patient also developed deep vein thrombosis and roxadustat-associated central hypothyroidism. Given the presence of multiple comorbidities, rituximab was subsequently used for vasculitis treatment, resulting in sustained remission. This case highlights the importance of highly individualized treatment strategies for older patients with vasculitis, requiring adjustment of immunosuppressive therapy intensity based on disease progression.

Objective:To explore the chain mediating role of professional identity and positive coping between leadership empowerment and work engagement of clinical research nurses (CRNs) .Methods:Convenience sampling was used to select 250 CRNs working in Beijing Friendship Hospital, Capital Medical University from August to September 2024 for the study. The survey was conducted with the General Information Questionnaire, Utrecht Work Engagement Scale, Empowering Leadership Behavior Scale, Professional Identification Scale for Nurse, and Simplified Coping Style Questionnaire. The chain mediating effects were tested using Model 6 of the SPSS PROCESS program.Results:A total of 250 questionnaires were distributed, 236 questionnaires were recovered, and 223 valid questionnaires were recovered after excluding the regularly answered questionnaires, with an effective recovery rate of 89.20% (223/250). Mediating effect analysis revealed that leadership empowerment directly and positively predicted work engagement of CRNs, with a direct effect value of 0.194, accounting for 67.60% of the total effect. Leadership empowerment also had an impact on work engagement of CRNs through three mediating paths. Mediating path 1: leadership empowerment→professional identity→ work engagement, with an effect value of 0.036, accounting for 12.54% of the total effect. Mediating path 2: leadership empowerment → positive coping → work engagement, with an effect value of 0.049, accounting for 17.07% of the total effect. Mediating path 3: leadership empowerment → professional identity → positive coping → work engagement, with an effect value of 0.008, accounting for 2.79% of the total effect. The total mediating effect was 0.093, accounting for 32.40% of the total effect.Conclusions:Leadership empowerment can not only directly affect work engagement of CRNs, but also indirectly affect it through the mediating role of professional identity and positive coping.

Objective:To explore the chain mediating role of professional identity and positive coping between leadership empowerment and work engagement of clinical research nurses (CRNs) .Methods:Convenience sampling was used to select 250 CRNs working in Beijing Friendship Hospital, Capital Medical University from August to September 2024 for the study. The survey was conducted with the General Information Questionnaire, Utrecht Work Engagement Scale, Empowering Leadership Behavior Scale, Professional Identification Scale for Nurse, and Simplified Coping Style Questionnaire. The chain mediating effects were tested using Model 6 of the SPSS PROCESS program.Results:A total of 250 questionnaires were distributed, 236 questionnaires were recovered, and 223 valid questionnaires were recovered after excluding the regularly answered questionnaires, with an effective recovery rate of 89.20% (223/250). Mediating effect analysis revealed that leadership empowerment directly and positively predicted work engagement of CRNs, with a direct effect value of 0.194, accounting for 67.60% of the total effect. Leadership empowerment also had an impact on work engagement of CRNs through three mediating paths. Mediating path 1: leadership empowerment→professional identity→ work engagement, with an effect value of 0.036, accounting for 12.54% of the total effect. Mediating path 2: leadership empowerment → positive coping → work engagement, with an effect value of 0.049, accounting for 17.07% of the total effect. Mediating path 3: leadership empowerment → professional identity → positive coping → work engagement, with an effect value of 0.008, accounting for 2.79% of the total effect. The total mediating effect was 0.093, accounting for 32.40% of the total effect.Conclusions:Leadership empowerment can not only directly affect work engagement of CRNs, but also indirectly affect it through the mediating role of professional identity and positive coping.

A 70-year-old female patient presented with fatigue and edema for 3 months and was found to have elevated serum creatinine for 3 weeks. During the course of the disease, she had fever and cough. Examinations revealed multiple ground-glass opacities in both lungs and positivity for myeloperoxidase-anti-neutrophil cytoplasmic antibodies (ANCA), leading to a diagnosis of ANCA-associated vasculitis. The patient′s condition initially improved after pulse glucocorticoid therapy combined with cyclophosphamide. During treatment, however, the patient developed hematochezia, and colonoscopy revealed multiple colonic ulcers. Immunohistochemistry of colonic mucosal biopsy confirmed cytomegalovirus (CMV) positivity, establishing a diagnosis of CMV colitis. The patient was found to have concurrent Clostridioidesdifficile and pulmonary infections. During the disease course, the patient also developed deep vein thrombosis and roxadustat-associated central hypothyroidism. Given the presence of multiple comorbidities, rituximab was subsequently used for vasculitis treatment, resulting in sustained remission. This case highlights the importance of highly individualized treatment strategies for older patients with vasculitis, requiring adjustment of immunosuppressive therapy intensity based on disease progression.

Background::Asthma imposes a large healthcare burden in China and the United States (US). However, the trends of asthma mortality and the relative risk factors have not been comparatively analyzed between the countries. The aim of this study was to compare the mortality and risk factors between China and the US.Methods::The deaths, and mortality rates of asthma in China and the US during 1990–2019 were obtained from the Global Burden of Disease Study 2019. The age–period–cohort model was used to estimate these mortality rates based on a log-linear scale with additive age, period, and cohort effects. The population attributable fractions of risk factors for asthma were estimated.Results::In 1990–2019, the asthma mortality rate was higher in China than in the US. The crude and age-standardized asthma mortality rates trended downward in both China and the US from 1990 to 2019. The decline in mortality was more obvious in China. Mortality gap between the two countries was narrowing. A sex difference in asthma mortality was observed with higher mortality in males in China and females in the US. The age effects showed that mortality increased with age in adults older than 20 years, particularly in the elderly. Downward trends were generally observed in the period and cohort rate ratios in both countries, with China experiencing a more obvious decrease. Smoking and high body mass index (BMI) were the leading risk factors for asthma mortality in China and the US, respectively. Mortality attributable to occupational asthmagens and smoking decreased the most in China and the US, respectively.Conclusions::In 1990–2019, the asthma mortality rate was higher in China than in the US; however, the mortality gap has narrowed. Mortality increased with age in adults. The improvements in asthma death risk with period and birth cohort were more obvious in China than in the US. Smoking, high BMI, and aging are major health problems associated with asthma control. The role of occupational asthmagens in asthma mortality underscores the importance of management and prevention of occupational asthma.

Glioma is the most common primary intracranial tumor. Despite surgical resection, radiation therapy, chemotherapy, and Tumor Treating Fields, the median survival period is still less than 21 months. In recent years, immunotherapy for glioma has become a research hotspot. The immune microenvironment of glioma plays an important role in immune escape, which is an important means of malignant progression. Exploring the immune escape mechanism of glioma, understanding the progress of immunotherapy, and extending the survival period of patients with glioma as much as possible are the major challenges facing glioma treatment. Therefore, this article reviews the new understanding of the immune system in the central nervous system, immune cells and immune escape in glioma, and immunotherapy for glioma, to help further understand the mechanism of glioma development and provide new ideas for immunotherapy.

Objective:To explore the normal ranges of perfusion parameters between cerebral hemisphere, cerebellar hemisphere and brain anatomical subregions (56 pairs) in different gender and age groups with multiple post labeling delay time (Multi-PLD) arterial spin labeling (ASL) imaging.Methods:From November 2020 to December 2020, 42 healthy adult volunteers (Male 25, Female 17) were recruited to perform 7 PLD ASL imaging, including 21 young adults (15 males and 6 females, aged 23—35 years) and 21 seniors (10 males and 11 females, aged 36—74 years). The data was processed offline by Cereflow software to obtain arterial arrival time (ATT) and corrected cerebral blood flow (CBF) and cerebral blood volume (CBV) perfusion parameters. SimpleITK standardization function was used to standardize the calculated perfusion image according to the anatomical automatic labeling (AAL) template. Therefore, CBF, ATT, CBV perfusion values of brain subregions were obtained. Paired samples t test, Wilcoxon rank sum test, independent samples t test and Mann-Whitney U test were used to compare the differences of perfusion parameters in the cerebral hemisphere, the cerebellar hemisphere, brain subregions depending on side, gender and age. Pearson correlation analysis was used to compare the correlations of perfusion parameters with age. Results:CBF in 62.5% (35/56) subregions and CBV in 44.6% (25/56) subregions were higher in right side than those in left side. ATT in most brain anatomical subregions (16/56) were higher in left side. The CBF [(35.30±8.31) vs. (34.34±7.53) ml·100g -1·min -1, P=0.021], CBV [(0.47±0.11) vs. (0.45±0.09) ml/100g, P<0.001], ATT [(1.30±0.10) vs. (1.24±0.11) s, P<0.001] in left cerebellar hemisphere were higher than that of right side. The CBF (28/56) of cerebral hemisphere, cerebellar hemisphere and brain subregions was higher in females than that in males, while ATT in 83.9% (47/56) subregions was lower than that in males (all P<0.05). CBV in female subjects was higher only in 5 brain regions (superior occipital gyrus, middle occipital gyrus, inferior occipital gyrus, superior parietal gyrus and cerebelum_7b) (all P<0.05). In young subjects, CBF in 44.6% (25/56) subregions and CBV in 33.9% (19/56) subregions were higher than those in the senior group (all P<0.05). The ATT in most subregions in young group were lower than those in senior group, but the difference was statistically significant only in rectus gyrus ( P=0.026) and paracentral lobule ( P=0.006). The CBF ( r=-0.430, P=0.005) and CBV ( r=-0.327, P=0.035) of cerebral hemisphere were negatively correlated with age. The CBF (24/25, r range:-0.497 —-0.343, all P<0.05) and CBV (16/19, r range:-0.474 —-0.322, all P<0.05) in most subregions were negatively correlated with age, while ATT was positively correlated (gyrus rectus: r=0.311, P=0.045; paracentral lobule: r=0.392, P=0.010). Conclusions:Multi-PLD ASL imaging could be applied for quantitative analysis of brain perfusion. The perfusion parameters of anatomical subregions are different depending on side, gender, and age.

Objective:To explore the effect of multidisciplinary collaborative discharge preparation service in elderly patients with chronic pancreatitis.Methods:From January 2020 to March 2021, a total of 152 elderly patients with chronic pancreatitis who were hospitalized in Department of Geriatrics of Beijing Friendship Hospital Capital Medical University were selected by convenience sampling method and divided into the observation group and the control group (76 cases in each group) using random number table method. The control group conducted conventional nursing, and the observation group carried out multidisciplinary collaboration discharge preparation services based on conventional nursing. Laboratory indicators, quality of life (SF-36) , readmission rates, and clinical stage progression were investigated.Results:After discharge, hemoglobin, prealbumin, albumin and SF-36 scores of the observation group were higher than those of the control group, while the fasting blood glucose of the observation group was lower than that of the control group, and the differences were statistically significant ( P<0.05) . Hemoglobin, prealbumin, albumin and SF-36 scores of the observation group after discharge were higher than those before discharge, and the differences were statistically significant ( P<0.05) . The readmission rates of the observation group and the control group were 14.47% and 21.58% respectively, and the clinical stage progression rates were 10.53% and 25.00% respectively. The differences in the readmission rate (χ 2=6.273, P<0.05) and clinical stage progression rate (χ 2=5.449, P<0.05) between the two groups were statistically significant. Conclusions:Multidisciplinary collaborative discharge preparation services applied to elderly patients with chronic pancreatitis can effectively improve patients' nutritional status and quality of life, reduce readmission rates and delay disease progression.

Objective:To investigate the status quo and influence factors of job burnout among nursing assistants in geriatric ward.Methods:From January to October 2021, a total of 200 nursing assistants were selected in geriatric ward of Beijing Friendship Hospital Affiliated to Capital Medical University by the convenient sampling method. Questionnaires were used to collect the general information of nursing assistants, such as gender, age, education level, working years, and time of taking care current elderly patients as well as the general information of the elderly patients, including gender, age, body mass index (BMI), activity of daily living, comorbidity index and so on. The Chinese version of the Maslach Occupational Questionnaire (MBI-GS) was used to investigate the status quo of job burnout among nursing assistants in geriatric ward. Univariate and multivariate Logistic regression were used to analyze the influencing factors of job burnout among nursing assistants in geriatric ward.Results:Among 200 nursing assistants, the incidence of job burnout was 49.00% (98/200), including 64.29% (63/98) mild burnout, 23.47% (23/98) moderate burnout, 12.24% (12/98) severe burnout. There were significant differences in working years, the time of taking care current elderly patients, average monthly income, working hours in one year, degree of respect from family members, job satisfaction and whether they had experienced provocation behaviors among nursing assistants with different job burnout levels ( P<0.05). There were significant differences in elderly patients' age, vision status, pressure sore score, Instrumental Activity of Daily Living (IADL) score, Activity of Daily Living (ADL) score among nursing assistants with different job burnout levels ( P<0.05). Logistic regression analysis showed that working years, average monthly income, annual working hours, degree of respect from family members, experienced aggressive behavior, and visual status, pressure sore score, IADL score, ADL score of the elderly patients were the influencing factors of job burnout among nursing assistants in geriatric ward ( P<0.05) . Conclusions:Nursing assistants in geriatric ward generally have job burnout, mainly mild burnout, and working years, average monthly income, annual working hours, degree of respect from family members, experienced aggressive behavior, and visual status, pressure ulcer score, IADL score and ADL score of the elderly patients were the influencing factors of job burnout.