The hepatocellular carcinoma(HCC)poses a serious threat to human health.The main target of one of the immunotherapeutic approaches is γδT cells.γδT cells as one of the subpop-ulations of T lymphocytes can directly recognize and target HCC cells,making them a potential target for immunotherapy.In this paper,we discussed the biological properties of γδ T cells and their dual roles within HCC cells and therapeutic strategies,and provide an overview on the research of γδT cell therapy for HCC.