Objective:Exploring the performance characteristics of spontaneous nystagmus（SN） in video-head impulse test（vHIT） and its possible effects on saccade. Methods:Vestibular function tests such as vHIT and SN were conducted in 48 patients with acute unilateral vestibulopathy（AUVP）. The saccade characteristics of vHIT in patients without SN and those with SN were analyzed, as well as the expression characteristics of SN in vHIT. Results:Among the 48 AUVP patients, there were 34 cases with SN, including 31 cases with saccade on the healthy side, 11 cases with both the same and opposite directions of eye movement, 19 with the opposite only, 1 with same direction only, and 3 cases without saccade. There were 14 patients without SN, of whom 10 showed saccade on the healthy side, including 4 with both eye movements in the same and opposite direction, 2 in the opposite direction only, 4 in the same direction only, and 4 without saccade. There is a correlation between reverse saccade on the healthy side and the presence of SN in patients. SN in vHIT can appear opposite to the direction of eye movement on the healthy side, while on the affected side it can appear the same as the direction of eye movement and may cause more discrete overt saccade. 32 patients in the acute phase（≤2 w）, 29 patients with SN, SN intensity of（6.7 ± 3.2） °/s, and 3 patients without SN. 16 cases in non acute phase（>2 w）, 5 cases with SN, SN intensity of（3.7 ± 2.1） °/s, and 11 cases without SN. In the acute phase there were 30 cases of saccade on the healthy side, 10 cases with both the same and opposite direction of eye movement, 18 cases with only the opposite direction, 2 cases with only the same direction and 2 cases without saccade. There is a correlation between the duration of the disease and the occurrence of reverse saccade on the healthy side. The intensity cut off point of SN for reverse saccade is 2.1 °/s in the healthy lateral semicircular canal vHIT. Conclusion:Compensatory saccades and SN waves with similar waveforms are mostly present in vHIT in AUVP patients. SN wave is in the opposite direction of the normal side and eye movement wave, and the affected side and dominant saccade direction are in the same direction and mixed together, which can affect the dispersion and amplitude of overt saccade in vHIT. Accurate identification of SN in vHIT of AUVP patients is not only the key factor to identify compensatory saccade, but also can provide help for the diagnosis and compensatory assessment of AUVP.
Humans ; Head Impulse Test/methods* ; Nystagmus, Pathologic/physiopathology* ; Saccades/physiology* ; Male ; Female ; Vestibular Diseases/physiopathology* ; Middle Aged ; Adult ; Eye Movements/physiology* ; Aged

Objective To analyze the changes of hematological parameters and coagulatory function in sever fever with thrombocytopenia syndrome (SFTS) in Zhoushan island.Methods Automated blood analyzer and automatic coagulation analyzer were used to measure hematological parameters and coagulatory function in SFTS patients before and after ten days treatment.Results The counts of white blood cells (WBC),neutrophils and lymphocytes and platelets of the 27 cases with SFTS were significantly lower than those of normal controls (P ＜ 0.05) ; Moreover,the counts of platelets was significantly higher in the cases who recovered as compared with those who died (P ＜ 0.05).Prothrombin time (PT),activated partial thromboplastin time (APTT) and thrombin time (TT) of SFTS patients before treatment were longer than normal controls,whereas fibrinogen (FIB) was lower (P ＜ 0.05).Pearson correlation analysis showed that APTT and platelet (PLT) of SFTS patients before treatment had significantly negative correlation (P ＜ 0.05),as well as PT,APTT and TT were negatively correlated with PLT of SFTS patients with 10 d treatment.Conclusion Paying close attention to the hematological parameters and coagulation function,especially PLT and APTT,has important clinical significance in diagnosis and monitoring of disease progression in patients with SFTS.