Objective To investigate the clinical characteristics in an elderly patient with sellar multiple myeloma.Methods Clinical features,laboratory data and radiologic profile of an elderly patient with sellar multiple myeloma were collected.Results The patient was an 85-year-old male.The main clinical manifestations were fatigue,poor appetite and polyuria.Laboratory examinations showed a significant decrease in blood sodium,several anterior pitu-itary hormones and an increase in total protein,mass of pituitary lesion and concentration of prolactin.During etio-logical screening,it was found that the blood immunoglobulin G(IgG)level was significantly increased,the blood M protein was positive and the bone marrow smear showed myeloma cells accompanied by multiple osteolytic lesions in the bones of the whole body.Considering the diagnosis of multiple myeloma,the pituitary lesion was likely to be the extra-medullary involvement.Conclusions The intrasellar plasmacytoma is not common.The disease onset is insidious with clinical features and imaging findings lacking specificity.Therefore,diagnosis relies on biopsy which poses risks for elderly patients and increases diagnostic challenges leading to misdiagnosis.

【Objective】 To analyze the relevant studies on blood donor cohort and explore the current research status, research hotspots and development trends of blood donor cohort studies abroad. 【Methods】 Based on the Web of Science Core Collection, the literature related to blood donor cohort was searched. After screening and data processing, bibliometric analysis was carried out from the volume of literature trends, disciplines, authors, institutional distribution and other aspects of the included literature. At the same time, CiteSpace 5.6R5 software was used to carry out visual analysis of countries/regions, literature co-citation, keyword co-occurrence, keyword clustering and keyword emergence. Results A total of 672 papers (654 research papers, 18 review papers) were included. The total number of papers published in the field of blood donor cohort study showed a steady upward trend since 1991, the fastest growth was between 2019 and 2020. The top three cited authors were Kaaks R (1 301 citations), Rinaldi S (1 186 citations) and Riboli E (1 130 citations); the top three institutions were RLUK library in the UK, the University of California and the University of Copenhagen; the top three countries/regions in the volume of literature were the United States (176 papers), Germany (64 papers) and France (54 papers), and they all co-operated closely with other countries. The top five keywords were "blood donor" , "prevalence" , "infection" , "risk" and "antibody" . A total of 19 clusters were obtained by keyword cluster analysis, it was reflected in the immune mechanism and prevalence of blood-borne diseases, the relationship between blood donation behavior and non-communicable disease and its influencing factors, and the classification of the characteristics of blood donors. "Non-hepatitis B" was the keyword with the greatest burst intensity. The keywords that have burst out in recent years and continue to this day include "donation" , "seroprev-alence" , "donor" and "management" . Conclusion At present, the cohort study of blood donors has been paid more and more attention in the world, and its research trends mainly focus on the study of transfusion-transmitted disease risk. However, more researches begin to pay attention to the health problems and influencing factors of blood donors or recipients, which provides the research ideas and directions for establishing cohort study among blood donors in China.

Objective:To explore the value of octreotide suppression test(OST) in predicting the efficacy of somatostatin receptor ligands(SRLs) in the treatment of active acromegaly.Methods:The clinical data of 76 patients with active acromegaly from 2011 to 2020 was retrospectively analyzed. OST was carried out as follows: After an overnight fasting and baseline sampling of growth hormone(GH), 100 μg octreotide was subcutaneously injected, and sampling for GH was obtained every 2 hours for 8 hours. All patients were treated with SRLs for at least 3 months. A good GH response is defined as a post-treatment random GH<1 μg/L or >80% fall compared with the baseline GH. A good insulin-like growth factor Ⅰ(IGF-Ⅰ) response is defined as IGF-Ⅰ<1.3 upper limit of normal(ULN) or >50% reduction compared with the baseline. If both GH and IGF-Ⅰ fulfill the criteria of a good response, it is defined as a good GH and IGF-Ⅰ response.Results:The baseline level of GH during OST was 15.00(6.38, 34.20) μg/L, the median time to reach the nadir GH was(3.65±1.65) hours, and the nadir GH level was 1.47(0.50, 4.19) μg/L. The median GH suppression rate was 89.12%(72.71%, 95.09%). When the cutoff value of GH suppression rate in predicting a good GH response was 89.32%, the area under the curve(AUC) was 0.74, with a sensitivity of 81.80% and specificity of 66.00%. When the cutoff value of GH suppression rate in predicting a good IGF-Ⅰ response was 93.14%, the AUC was 0.64, with a sensitivity of 50.00% and specificity of 75.60%. When the GH suppression rate was 90.71%, the AUC was 0.78, with the sensitivity of 83.30% and specificity of 70.00% in predicting a good GH and IGF-Ⅰ response. Compared with GH/IGF-Ⅰ non-responders, GH/IGF-Ⅰ responders displayed lower nadir GH during OST, higher GH suppression rate and IGF-Ⅰ reduction rate, and lower ratio of IGF-1 to ULN( P<0.05). Conclusion:GH suppression rate during the OST is a valuable predictor to evaluate the efficacy of SRLs in patients with acromegaly, with the highest sensitivity and specificity when the cutoff value is 90.71%.

Objective To observe the effects of deep saturation diving on urine volume and trace elements in the urine of the divers , so as to provide theoretical evidence for medical support of deep saturation diving operations and health promotion of divers .Methods Four male healthy divers participated in the 480 msw simulated saturation dive .Twenty-four-hour urine samples were collected the day before entrance into the chamber , during their stay daily in the chamber , and the day after they came out of the chamber .The contents of Ba, Co, Cr, Cu, Fe, Mn, Pb, Sr, Zn in the urine samples were determinated with inductively coupled plasma atomic emission spectrometry , and the data obtained were analyzed with LSD variance analysis .Results Urine volumes of the divers at days 4, 7, 8, 10, 17 and 18 in the chamber were significantly higher than those of both day 1 before enterance into the chamber and the day after surfacing out of the chamber .The urine volume at day 15 in the chamber was significantly higher than that of 1 day before enterance into the chamber . In the 24 h urine samples, the excretion of Ba reached peak at days 10 and 11, and urine volumes at days 16, 18, 19 were significantly lower than those at days 1-11.The excretions of Cr and Co at days 16, 18 and 19 were significantly lower than those at days 1-11.The peak excretions of Fe and Mn all appeared at days 10 and 11, and the peak excretion of Pb was at days 8 and 10.However, the peak excretion of Sr was relatively stable, reaching the peak at day 12.The peak excretion of Zn was at day 8, then decreased gradually and finally reached the bottom at day 19.The peak excretion of Cu at day 10 increased sharply , then decreased gradually and reached bottom at day 19.Conclusions Deep saturation diving exerted certain effects on the urine volume and the metabolism of trace elements in urine in divers .Further research efforts should be made in this respect, so as to provide better medical support and promote the health of divers in special diving operations .

Objective To explore the effects of deep saturation diving on blood biochemical indices in divers and to analyze the possible causes involved , so as to provide theoretical evidence for the development of medical support profile for the health promotion of divers .Methods Four healthy male divers participated in the 4.9 MPa (480 m) simulated saturation dive.The serum levels of total protein (TP), albumin (ALB), Globulin (GLB), total cholesterol (TC), triglyceride (TG), glucose (Glu), Creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), immunoglobulin IgA, IgG, IgM, complement C3, C4 were detected by Olympus 2 700 automatic biochemical analyzer .In addition, serum electrolytes potassium ( K+), sodium ( Na+) , magnesium ( Mg2+) , calcium ( Ca2+) , Iron ( Fe3+) and chlorine ( Cl-) were determined by Toshiba 40FR automatic biochemical analyzer .Results Serum UA level (387.75 ±35.37) μmol/L of the divers after they came out of the chamber upon completion of the deep saturation dive was obviously lower than that before the entrance into the chamber (482.75 ±75.20) μmol/L (P<0.05).Serum K +level of the divers (4.00 ± 0.14) mmol /L after they came out of the chamber was markedly lower than that before entrance into the chamber(4.30 ±0.29)mmol/L (P <0.05).IgA level of the divers after they came out of the chamber (2.36 ±0.62)g/L was obviously higher than that before entrance into the chamber (1.92 ±0.72)g/L(P<0.05), while C3 level of the divers after exposure (1.02 ±0.11) g/L was lower than that before exposure (1.20 ±0.26) g/L ( P <0.05).Conclusions Deep saturation dive had certain effects on the serum biochemical indices of the divers .Monitoring on the biochemical indices should be enhanced and medical support measures be improved , so as to ensure the health of divers .

Objective To observe the effects of deep saturation diving on urine volume and trace elements in the urine of the divers , so as to provide theoretical evidence for medical support of deep saturation diving operations and health promotion of divers .Methods Four male healthy divers participated in the 480 msw simulated saturation dive .Twenty-four-hour urine samples were collected the day before entrance into the chamber , during their stay daily in the chamber , and the day after they came out of the chamber .The contents of Ba, Co, Cr, Cu, Fe, Mn, Pb, Sr, Zn in the urine samples were determinated with inductively coupled plasma atomic emission spectrometry , and the data obtained were analyzed with LSD variance analysis .Results Urine volumes of the divers at days 4, 7, 8, 10, 17 and 18 in the chamber were significantly higher than those of both day 1 before enterance into the chamber and the day after surfacing out of the chamber .The urine volume at day 15 in the chamber was significantly higher than that of 1 day before enterance into the chamber . In the 24 h urine samples, the excretion of Ba reached peak at days 10 and 11, and urine volumes at days 16, 18, 19 were significantly lower than those at days 1-11.The excretions of Cr and Co at days 16, 18 and 19 were significantly lower than those at days 1-11.The peak excretions of Fe and Mn all appeared at days 10 and 11, and the peak excretion of Pb was at days 8 and 10.However, the peak excretion of Sr was relatively stable, reaching the peak at day 12.The peak excretion of Zn was at day 8, then decreased gradually and finally reached the bottom at day 19.The peak excretion of Cu at day 10 increased sharply , then decreased gradually and reached bottom at day 19.Conclusions Deep saturation diving exerted certain effects on the urine volume and the metabolism of trace elements in urine in divers .Further research efforts should be made in this respect, so as to provide better medical support and promote the health of divers in special diving operations .

Objective To explore the effects of deep saturation diving on blood biochemical indices in divers and to analyze the possible causes involved , so as to provide theoretical evidence for the development of medical support profile for the health promotion of divers .Methods Four healthy male divers participated in the 4.9 MPa (480 m) simulated saturation dive.The serum levels of total protein (TP), albumin (ALB), Globulin (GLB), total cholesterol (TC), triglyceride (TG), glucose (Glu), Creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), immunoglobulin IgA, IgG, IgM, complement C3, C4 were detected by Olympus 2 700 automatic biochemical analyzer .In addition, serum electrolytes potassium ( K+), sodium ( Na+) , magnesium ( Mg2+) , calcium ( Ca2+) , Iron ( Fe3+) and chlorine ( Cl-) were determined by Toshiba 40FR automatic biochemical analyzer .Results Serum UA level (387.75 ±35.37) μmol/L of the divers after they came out of the chamber upon completion of the deep saturation dive was obviously lower than that before the entrance into the chamber (482.75 ±75.20) μmol/L (P<0.05).Serum K +level of the divers (4.00 ± 0.14) mmol /L after they came out of the chamber was markedly lower than that before entrance into the chamber(4.30 ±0.29)mmol/L (P <0.05).IgA level of the divers after they came out of the chamber (2.36 ±0.62)g/L was obviously higher than that before entrance into the chamber (1.92 ±0.72)g/L(P<0.05), while C3 level of the divers after exposure (1.02 ±0.11) g/L was lower than that before exposure (1.20 ±0.26) g/L ( P <0.05).Conclusions Deep saturation dive had certain effects on the serum biochemical indices of the divers .Monitoring on the biochemical indices should be enhanced and medical support measures be improved , so as to ensure the health of divers .