Objective:To explore the correlation among disease uncertainty,quality of life and psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Methods:This study was a prospective study.A total of 106 patients who underwent radical gastrectomy for gastric cancer and were admitted to Shanxi Integrated Traditional Chinese and Western Medicine Hospital from July 2023 to July 2024 were included in observation group.Connor-davidson resilience scale(CD-RISC),Mishel disease uncertainty scale(MUIS)and European qrganization for research and treatment of cancer quality of life questionnaire-C30(EORCT QLQ-C30)were used to evaluate the psychological resilience,disease uncertainty and quality of life of observation group.Pearson test was used to analyze the correlations among disease uncertainty,quality of life and psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Univariate and multivariate logistic regression analyses were used to investigate the influencing factors of decreased postoperative psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Result:Pearson test analysis showed that,the MUIS score and EORCT QLQ-C30 score of patients undergoing radical gastrectomy for gastric cancer was negatively correlated with CD-RISC(P＜0.05).Through univariate analysis,age,educational level,annual family income,MUIS and EORCT QLQ-C30 were the influencing factors of decreased psychological resilience in patients undergoing radical gastrectomy for gastric cancer(P＜0.05).Multivariate logistic analysis showed that,increased age,educational level of primary school or below,annual family income＜50,000 yuan,increased MUIS score and increased EORCT QLQ-C30 score were independent risk factors for decreased psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Conclusion:The disease uncertainty,quality of life and psychological resilience of patients undergoing radical gastrectomy for gastric cancer are negatively correlated.Increased age,educational level of primary school or below,annual family income＜50,000 yuan,increased MUIS score and increased EORCT QLQ-C30 score are independent risk factors for decreased psychological resilience in patients undergoing radical gastrectomy for gastric cancer.

Objective:To investigate the correlation between postoperative perceived stress,quality of life and fear of cancer recurrence(FCR)in elderly non-small-cell lung cancer(NSCLC)patients.Methods:This study was a prospective research design,a total of 147 elderly NSCLC patients who visited Shanxi Integrated Traditional Chinese and Western Medicine Hospital from January 2023 to June 2024 were prospectively selected for the study.All patients underwent thoracoscopic lobectomy.FCR in patients was evaluated by fear of disease progression simplified scale(FoP-Q-SF),and they were divided into dysregulation group and non dysregulation group according to the FoP-Q-SF score.Quality of life was evaluated by functional assessment of cancer therapy-lung cancer(FACT-L).Perceived stress was evaluated by Chinese version of the perceived stress scale(CPSS)score.The scores of postoperative perceived stress,quality of life and postoperative FCR in elderly NSCLC patients were analyzed,and the influence of demographic and clinical characteristics on the postoperative FCR in elderly NSCLC patients.The postoperative perceived stress and quality of life scores of elderly NSCLC patients with different FCR were compared,the correlation between postoperative FCR and perceived stress and quality of life in elderly NSCLC patients were analyzed,as well as the model fitting index of the influence of postoperative perceived stress and quality of life on FCR in elderly NSCLC patients.Results:The postoperative CPSS score in elderly NSCLC patients was(52.17±4.02)points,the FACT-L score was(80.39±4.56)points,and the total score of FoP-Q-SF was(31.16±8.69)points.Family relationship,economic burden of disease,chemotherapy and clinical stage were closely associated with the postoperative FCR in elderly NSCLC patients(P＜0.05).The CPSS score in dysregulation group was higher than that in nondysregulation group,and the FACT-L score was lower than that in nondysregulation group(P＜0.05).Pearson correlation analysis,postoperative FCR in elderly NSCLC patients was positively correlated with perceived stress,but negatively correlated with quality of life(P＜0.05).The postoperative quality of life in elderly NSCLC patients was recorded as the independent variable,the postoperative perceived stress was recorded as the mediating variable,and the postoperative FCR was recorded as the dependent variable,a structural model of the mediating effect was routinely constructed.The results showed that the model fits well.Quality of life had a direct negative predictive effect on postoperative FCR in elderly NSCLC patients(P＜0.05),and could affect FCR through postoperative perceived pressure(P＜0.05),with the mediating effect accounting for 34.15％of the total effect.After repeatedly sampling the data using the Bootstrap method and implementing the mediating effect,the 95％CI of each model path did not include 0,indicating that the difference in the mediating effect was statistically significant(P＜0.05).Conclusion:Postoperative FCR in elderly NSCLC patients is positively correlated with perceived stress,but negatively correlated with quality of life,clinically,monitoring such indicators can be considered to better evaluate the postoperative FCR in elderly NSCLC patients.

OBJECTIVES: To explore the status and risk factors of neuropsychological development in small for gestational age (SGA) infants at corrected 12-24 months of age. METHODS: Clinical data were retrospectively collected for 754 SGA infants at corrected ages 12-24 months in Shenzhen Bao'an Women and Children's Hospital between April 2018 and December 2023. Developmental quotient (DQ) levels were analyzed. According to the presence of global developmental delay (GDD), participants were divided into a GDD group (71 cases) and a control group (683 cases), and the incidence and influencing factors of GDD were investigated. RESULTS: In the high-risk preterm SGA group, the total DQ and DQ in all domains were lower than in the full-term SGA group (P<0.017). The overall incidence of GDD was 9.4% (71/754) and increased with decreasing gestational age (P<0.017). Compared with the control group, the GDD group had higher proportions of males; low-risk and high-risk preterm birth; mothers with less than a bachelor's degree; multiple birth; neonatal hypoglycemia; neonatal pneumonia; neonatal respiratory distress syndrome; bronchopulmonary dysplasia; and, at corrected 12-24 months, low body weight, growth retardation, and microcephaly. The length of neonatal hospital stay was longer in the GDD group than in the control group (P<0.05). The weight-for-age Z score, length-for-age Z score, and head circumference-for-age Z score at birth and at corrected 12-24 months were lower in the GDD group than in the control group (P<0.05). Multivariable logistic regression showed that male sex and maternal education below a bachelor's degree were independent risk factors for GDD in SGA infants (P<0.05). CONCLUSIONS Neuropsychological development in preterm SGA infants is comparatively delayed; male SGA infants born to mothers with less than a bachelor's degree should receive priority attention.
Humans ; Female ; Male ; Infant, Small for Gestational Age/psychology* ; Risk Factors ; Infant ; Retrospective Studies ; Child Development ; Developmental Disabilities/epidemiology* ; Infant, Newborn ; Child, Preschool

Objective:To investigate the correlation between postoperative perceived stress,quality of life and fear of cancer recurrence(FCR)in elderly non-small-cell lung cancer(NSCLC)patients.Methods:This study was a prospective research design,a total of 147 elderly NSCLC patients who visited Shanxi Integrated Traditional Chinese and Western Medicine Hospital from January 2023 to June 2024 were prospectively selected for the study.All patients underwent thoracoscopic lobectomy.FCR in patients was evaluated by fear of disease progression simplified scale(FoP-Q-SF),and they were divided into dysregulation group and non dysregulation group according to the FoP-Q-SF score.Quality of life was evaluated by functional assessment of cancer therapy-lung cancer(FACT-L).Perceived stress was evaluated by Chinese version of the perceived stress scale(CPSS)score.The scores of postoperative perceived stress,quality of life and postoperative FCR in elderly NSCLC patients were analyzed,and the influence of demographic and clinical characteristics on the postoperative FCR in elderly NSCLC patients.The postoperative perceived stress and quality of life scores of elderly NSCLC patients with different FCR were compared,the correlation between postoperative FCR and perceived stress and quality of life in elderly NSCLC patients were analyzed,as well as the model fitting index of the influence of postoperative perceived stress and quality of life on FCR in elderly NSCLC patients.Results:The postoperative CPSS score in elderly NSCLC patients was(52.17±4.02)points,the FACT-L score was(80.39±4.56)points,and the total score of FoP-Q-SF was(31.16±8.69)points.Family relationship,economic burden of disease,chemotherapy and clinical stage were closely associated with the postoperative FCR in elderly NSCLC patients(P＜0.05).The CPSS score in dysregulation group was higher than that in nondysregulation group,and the FACT-L score was lower than that in nondysregulation group(P＜0.05).Pearson correlation analysis,postoperative FCR in elderly NSCLC patients was positively correlated with perceived stress,but negatively correlated with quality of life(P＜0.05).The postoperative quality of life in elderly NSCLC patients was recorded as the independent variable,the postoperative perceived stress was recorded as the mediating variable,and the postoperative FCR was recorded as the dependent variable,a structural model of the mediating effect was routinely constructed.The results showed that the model fits well.Quality of life had a direct negative predictive effect on postoperative FCR in elderly NSCLC patients(P＜0.05),and could affect FCR through postoperative perceived pressure(P＜0.05),with the mediating effect accounting for 34.15％of the total effect.After repeatedly sampling the data using the Bootstrap method and implementing the mediating effect,the 95％CI of each model path did not include 0,indicating that the difference in the mediating effect was statistically significant(P＜0.05).Conclusion:Postoperative FCR in elderly NSCLC patients is positively correlated with perceived stress,but negatively correlated with quality of life,clinically,monitoring such indicators can be considered to better evaluate the postoperative FCR in elderly NSCLC patients.

Objective:To explore the correlation among disease uncertainty,quality of life and psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Methods:This study was a prospective study.A total of 106 patients who underwent radical gastrectomy for gastric cancer and were admitted to Shanxi Integrated Traditional Chinese and Western Medicine Hospital from July 2023 to July 2024 were included in observation group.Connor-davidson resilience scale(CD-RISC),Mishel disease uncertainty scale(MUIS)and European qrganization for research and treatment of cancer quality of life questionnaire-C30(EORCT QLQ-C30)were used to evaluate the psychological resilience,disease uncertainty and quality of life of observation group.Pearson test was used to analyze the correlations among disease uncertainty,quality of life and psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Univariate and multivariate logistic regression analyses were used to investigate the influencing factors of decreased postoperative psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Result:Pearson test analysis showed that,the MUIS score and EORCT QLQ-C30 score of patients undergoing radical gastrectomy for gastric cancer was negatively correlated with CD-RISC(P＜0.05).Through univariate analysis,age,educational level,annual family income,MUIS and EORCT QLQ-C30 were the influencing factors of decreased psychological resilience in patients undergoing radical gastrectomy for gastric cancer(P＜0.05).Multivariate logistic analysis showed that,increased age,educational level of primary school or below,annual family income＜50,000 yuan,increased MUIS score and increased EORCT QLQ-C30 score were independent risk factors for decreased psychological resilience in patients undergoing radical gastrectomy for gastric cancer.Conclusion:The disease uncertainty,quality of life and psychological resilience of patients undergoing radical gastrectomy for gastric cancer are negatively correlated.Increased age,educational level of primary school or below,annual family income＜50,000 yuan,increased MUIS score and increased EORCT QLQ-C30 score are independent risk factors for decreased psychological resilience in patients undergoing radical gastrectomy for gastric cancer.

AIM To prepare the soluble microneedles of Aconitum brachypodum Diels alkaloids.METHODS Centrifugal molding method was adopted in the preparation of soluble microneedles.With chondroitin sulfate consumption,PVP K120 consumption and 40%ethanol consumption as influencing factors,piercing rate as an evaluation index,the formulation was optimized by Box-Behnken response surface method,after which the morphology,piercing performance,drug content and in vitro transdermal performance were investigated.RESULTS The optimal formulation was determined to be 123 mg for chondroitin sulfate consumption,298 mg for PVP K120 consumption,and 2.4 mL for 40%ethanol consumption,the piercing rate was 98.3%.The soluble microneedles were yellow and square patch with conoid needle,which could pierce aluminum foil and rat skin,along with the drug content of(0.94±0.025)mg.The soluble microneedle group demonstrated the accumulative permeability rate of 91.4%within 24 h,which was higher than that in the gel ointment group,and the permeability accorded with Higuchi equation.CONCLUSION The soluble microneedles of A.brachypodum alkaloids exhibit good mechanical strength,which can achieve effective transdermal delivery of drugs.

AIM: To investigate the current visual acuity of the preschool children in Tongzhou district of Beijing and analyze their refractive status.METHODS: A cross-sectional study. A total of 1 513 children(3 026 eyes)aged 3-6 years old from 9 kindergartens in Tongzhou District of Beijing were selected by cluster random sampling method from December 2021 to January 2022. Visual acuity and diopters were examined in all of them, and the distribution of visual acuity and diopters of children in different age groups were analyzed.RESULTS: The visual acuity abnormality rate of the included children was 15.47%, and the refractive abnormality rate was 14.24%, and the detection rate of abnormal refractive error decreased with the increase of age, while the type of abnormal refractive error was mainly simple myopic astigmatism(11.46%). With the increase of age, the rate of simple hyperopia gradually decreased, and the rate of simple myopia gradually increased. The diopters test results showed that the spherical diopters of the included children were 0.50(0.25, 1.00)D, the cylindrical diopters were -0.25(-0.50, -0.25)D, and the equivalent spherical diopters were 0.375(0, 0.625)D. There was no difference in equivalent spherical diopters among children of different ages(P>0.05), but there was difference in cylindrical diopters(P<0.001).CONCLUSION: The abnormal visual acuity rate of the children aged 3-5 years decreased gradually with the increase of age, and then increased after 6 years old. At 3-6 years, simple myopic astigmatism was the main refractive abnormality. Attention should be paid to the development of visual acuity in preschool children, and regular visual acuity and refractive status examinations should be carried out.

The establishment of limit values for standards of drinking water quality is an important and complex process. This study systematically introduced the methodology of the establishment of standard limit values for drinking water quality and elaborated on the workflow of setting limit values of water quality indicators, principles and methods of selecting water quality indicators, derivation of safety reference values, and establishment of limit values. It also aimed to provide reference and support for the future revision of relevant standards.
Humans ; Water Supply ; Drinking Water ; Reference Standards ; Water Quality ; Water Pollutants, Chemical/analysis*

Female ; Humans ; Sarcoma, Endometrial Stromal/surgery* ; Transcription Factors/genetics* ; Endometrial Neoplasms/surgery* ; DNA-Binding Proteins ; Co-Repressor Proteins ; Repressor Proteins/genetics*

The purpose of this study was to explore the clinical efficacy and safety of Gynostemma pentaphyllum (G. pentaphyllum) in the treatment of hyperlipidemia, and to provide systematic evaluation basis for clinical application. CNKI, Wanfang Data, VIP, Web of science, PubMed, Embase and Cochrane Library were searched for randomized controlled trials (RCTs) about G. pentaphyllum in the treatment of hyperlipidemia. Review Manager 5.4 were used for statistical analysis. Through reading topics, abstracts, and full texts, 27 papers with 2311 cases involved that met the inclusion and exclusion criteria were finally included for the analysis. In terms of curative effect, the effect of G. pentaphyllum alone in increasing high density lipoprotein (HDL) index was better than that of conventional treatment, and the effect of reducing total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) was similar to that of conventional treatment. There was a synergistic effect between G. pentaphyllum and conventional drugs, and the combination of G. pentaphyllum and conventional drugs was superior to conventional treatment in reducing TG and increasing HDL. G. pentaphyllum can also decrease the levels of serum glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in the treatment of hyperlipidemia, indicating a certain protective function of the liver. In terms of safety, there were fewer cases of adverse reactions in the G. pentaphyllum treatment group, and the adverse reaction events reported in the literature was mild. According to the results of meta-analysis, G. pentaphyllum was effective in the treatment of hyperlipidemia, and it has the potential to be combined with traditional drugs, has a certain liver protection function, and was superior to traditional drugs in the treatment of hyperlipidemia.