ObjectiveTo evaluate the effects and safety of the optimized new Shengmai Powder （优化新生脉散方） on exercise tolerance in patients with chronic heart failure （CHF） of qi deficiency， blood stasis， and fluid retention syndrome. MethodsA randomized， double-blind， placebo-controlled trial was conducted. A total of 78 CHF patients with qi deficiency， blood stasis， and fluid retention syndrome were recruited and randomly assigned to a treatment group （39 cases） and a control group （39 cases）. On the basis of conventional western medical therapy， patients in the treatment group additionally received the optimized new Shengmai Powder granules， while the control group was given an oral placebo of optimized new Shengmai Powder granules. Patients in both groups took 30.6 g each time， twice a day， mixed with water for administration， with a total treatment course of 4 weeks. The primary outcomes were 6-minute walk distance （6MWD） and peak oxygen uptake （Peak VO₂） measured by cardiopulmonary exercise testing. Secondary outcomes included New York Heart Association （NYHA） functional classification， B-type natriuretic peptide （BNP） levels， cardiac function indexes including left ventricular ejection fraction （LVEF）， left ventri-cular end-systolic diameter （LVESD） and left ventricular end-diastolic diameter （LVEDD）， Minnesota Living with Heart Failure Questionnaire （MLHFQ） scores， and scores of four diagnostic information of traditional Chinese medicine （TCM）. All indicators were assessed once before and after treatment respectively. Safety indicators were evaluated， and adverse events during the trial were recorded. ResultsAll patients in both groups were included in the full ana-lysis set （FAS） and safety set （SS）. Compared with baseline， the 6MWD and Peak VO₂ of cardiopulmonary exercise test in the treatment group significantly increased after treatment， while the MLHFQ scores， serum BNP levels and scores of TCM four diagnostic information significantly decreased， and the NYHA cardiac function grade significantly improved （P＜0.01）. After treatment， the 6MWD and Peak VO₂ of cardiopulmonary exercise test， as well as their changes from baseline in the treatment group were higher than those in the control group； the MLHFQ scores， serum BNP levels and scores of TCM four diagnostic information in the treatment group were lower than those in the control group； and the improvement of NYHA cardiac function grade in the treatment group was superior to that in the control group （P＜0.01）. There was no statistically significant differences in all indicators after treatment in the control group （P＞0.05）. The incidence of adverse events was 5.1% （2/39） in the treatment group and 2.6% （1/39） in the control group， with no statistically significant difference between groups （P＞0.05）. ConclusionOn the basis of conventional western medicine treatment， the addition of the optimized new Shengmai Powder can further improve exercise tolerance， cardiac function and quality of life in patients with CHF of qi deficiency， blood stasis and fluid retention syndrome， and show good safety.

AIM: To investigate the effects of tobramycin dexamethasone eye drops combined with diclofenac sodium eye drops on postoperative inflammatory markers and recurrence in patients with pterygium.METHODS: A retrospective study was conducted to collect the relevant data of 102 patients(102 eyes)with pterygium who were treated with tobramycin dexamethasone eye drops after pterygium excision and conjunctival transposition of autologous limbal epithelium from May 2021 to May 2024. They were divided into two groups according to different medication, including 51 eyes treated with tobramycin dexamethasone eye drops in control group and 51 eyes treated with tobramycin dexamethasone eye drops and diclofenac sodium eye drops in observation group, and both groups were treated for 4 wk. Followed-up for 6 mo, the levels of inflammatory factors at each time point, ocular symptom scores, lacrimal gland function, adverse reactions during the medication, and disease recurrence were compared.RESULTS: The time required for conjunctival flap congestion and corneal wound epithelial regression in the observation group was shorter than that in the control group(all P<0.001). At 1, 2, and 4 wk after surgery, the levels of interleukin-6(IL-6), IL-1β, and tumor necrosis factor-α(TNF-α)in both groups decreased compared to the day of surgery, and the levels of each indicator in the observation group were lower than those in the control group at all time points(all P<0.05). At 1 wk after surgery, the time for the first tear film rupture in both groups was shortened compared to before surgery(P<0.05), while there was no statistical significant difference in the Schirmer I test(SⅠt)between the two groups compared to before surgery(P>0.05). At 2 and 4 wk after surgery, the time of first tear film rupture and the SⅠt in both groups increased compared to before and 1 wk after surgery, and the observation group was better than the control group(all P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups of patients during medication(7.8% vs 3.9%, P>0.05). After a 6-month follow-up, the recurrence rate in the observation group was lower than that in the control group, but the difference was not statistically significant(3.9% vs 17.7%, P=0.051).CONCLUSION: The combination of tobramycin dexamethasone eye drops and diclofenac sodium eye drops for postoperative treatment of pterygium patients is more effective than using tobramycin dexamethasone eye drops alone. It is beneficial for alleviating postoperative inflammatory reactions, improving patient comfort, promoting postoperative lacrimal gland function recovery, reducing recurrence, and has higher safety.

Depression poses a severe threat to human health, placing a heavy burden on society and families. Yet, challenges remain in prevention and treatment. Lifestyle medicine aims to use evidence-based lifestyle interventions to prevent, treat, and even reverse chronic progression. Exploring breakthroughs in depression intervention prevention and treatment from the perspective of lifestyle medicine presents an opportunity for interdisciplinary research. Future research should focus on leveraging implementation science, cost-effectiveness analysis, and understanding optimal pathways and mechanisms of action. This article provides a review of this important topic.

Depression poses a severe threat to human health, placing a heavy burden on society and families. Yet, challenges remain in prevention and treatment. Lifestyle medicine aims to use evidence-based lifestyle interventions to prevent, treat, and even reverse chronic progression. Exploring breakthroughs in depression intervention prevention and treatment from the perspective of lifestyle medicine presents an opportunity for interdisciplinary research. Future research should focus on leveraging implementation science, cost-effectiveness analysis, and understanding optimal pathways and mechanisms of action. This article provides a review of this important topic.

At present, pancreatic cancer is a solid tumor with the worst prognosis. Compared with surgery and chemotherapy, radiotherapy plays an auxiliary role in the treatment of pancreatic cancer. In recent years, significant advances have been achieved in radiotherapy technology, which have been gradually applied in the diagnosis and treatment of pancreatic cancer. In this article, the progress in radiation therapy in the treatment of pancreatic cancer was reviewed, especially the clinical application of magnetic resonance imaging-guided radiation therapy in the treatment of pancreatic cancer, aiming to deepen the understand of the progress in radiation therapy for pancreatic cancer, and providing reference for improving the survival rate of pancreatic cancer patients.

Objective:To explore the mediating role of self-control in the relationship between alexithymia and internet addiction.Methods:From August to September 2019, a total of 433 college students were selected from three universities in Jiangxi province by cluster random sampling method. The Chinese internet addiction scale-revised, the twenty-item Toronto alexithymia scale and brief self-control scale were used for questionnaire testing. SPSS 23.0 software was used for descriptive statistics, Pearson correlation analysis and PROCESS V3.5 macro program was used to test the mediating effect.Results:The total scores of alexithymia, internet addiction and self-control were (53.61±9.44), (45.31±9.84) and (41.91±6.09), respectively. Pearson correlation analysis showed that alexithymia was significantly positively correlated with internet addiction ( r=0.47, P<0.01), and significantly negatively correlated with self-control ( r=-0.37, P<0.01). The negative correlation between self-control and internet addiction was significant ( r=-0.46, P<0.01). Multivariate hierarchical regression analysis showed that alexithymia directly predicted internet addiction after controlling the influence of gender. Self-control played a partially mediating role in the relationship between alexithymia and internet addiction (effect size=0.13, 95% CI: 0.082-0.185), the mediating effect accounted for 25% of the total effect. Conclusion:Alexithymia not only directly affects college students′ internet addiction, but also indirectly affects college students′ internet addiction through self-control.

Objective:To review the research methods, contents and research results of spatial disorientation (SD) accident analysis system, and point out the problems in the research and the future research direction. Literature sources and selection Relevant articles and reviews published in China and abroad. Literature quotation Thirty-six published papers and reviews were cited. Literature synthesis The development history of SD accident analysis system were reviewed, and the characteristics, advantages and disadvantages of 3 common spatial disorientation accident analysis systems were analyzed. The paper briefly introduced the application of the spatial disorientation accident analysis system on aviation accidents analysis by taking the American International Aerospace Training and Research Center developed system as an example. Finally, the paper prospected the direction and trend of the development. Conclusion:The SD accident analysis system visualizes the causal relationship of SD accidents and further analyzes and studies SD accidents so as to reduce the occurrence of SD accidents.

Objective:To review the research methods, contents and research results of spatial disorientation (SD) accident analysis system, and point out the problems in the research and the future research direction. Literature sources and selection Relevant articles and reviews published in China and abroad. Literature quotation Thirty-six published papers and reviews were cited. Literature synthesis The development history of SD accident analysis system were reviewed, and the characteristics, advantages and disadvantages of 3 common spatial disorientation accident analysis systems were analyzed. The paper briefly introduced the application of the spatial disorientation accident analysis system on aviation accidents analysis by taking the American International Aerospace Training and Research Center developed system as an example. Finally, the paper prospected the direction and trend of the development. Conclusion:The SD accident analysis system visualizes the causal relationship of SD accidents and further analyzes and studies SD accidents so as to reduce the occurrence of SD accidents.

Objective:To evaluate the role of SphK1/S1P signaling pathway in adiponectin-induced restoration of attenuation of myocardial ischemia-reperfusion (I/R) injury by sevoflurane postconditioning in diabetic rats.Methods:Healthy clean-grade male Sprague-Dawley rats, aged 8-10 weeks, weighing 250-300 g, in which diabetes mellitus was induced by combination of high-fat and high-sucrose diet and intraperitoneal injection of 1% streptozotoein in citric acid buffer 40 mg/kg, were studied.Ninety rats with diabetes mellitus were divided into 6 groups ( n=15 each) using a random number table method: sham operation group (group Sham), group I/R, sevoflurane postconditioning group (group S), adiponectin preconditioning group (group A), adiponectin preconditioning+ sevoflurane postconditioning group (group AS) and adiponectin preconditioning+ K6PC-5 (a specific SphK1 activator)+ sevoflurane postconditioning group (group AKS). Myocardial I/R was induced by 30 min occlusion of anterior descending branch of left coronary artery followed by 120 min reperfusion.At 15 min before ischemia, recombinant adiponectin 5.0 μg/g was injected intraperitoneally in A, AS and AKS groups, and K6PC-5 1 μg/g was injected via the tail vein in group AKS.In S, AS and AKS groups, 2.5% sevoflurane was inhaled for 5 min starting from the onset of reperfusion.Blood samples from the internal jugular vein were collected at the end of reperfusion for determination of serum cardiac troponin I (cTnI) concentration (by enzyme-linked immunosorbent assay), percentage of myocardial infarct volume (by TTC staining) and expression of SphK1, S1P and phosphorylated NF-κB p65 (p-NF-κB p65) in myocardial tissues (by Western blot). Results:Compared with group Sham, the serum cTnI concentration and percentage of myocardial infarct volume were significantly increased, and expression of SphK1, S1P and p-NF-κB p65 in myocardial tissues was up-regulated in group I/R ( P<0.05). Compared with group I/R, no significant change was found in each parameter in group S ( P>0.05), and the serum cTnI concentration and percentage of myocardial infarct volume were significantly decreased, and expression of SphK1, S1P and p-NF-κB p65 in myocardial tissues was down-regulated in group A ( P<0.05). Compared with group S, the serum cTnI concentration and percentage of myocardial infarct volume were significantly decreased, and expression of SphK1, S1P and p-NF-κB p65 in myocardial tissues was down-regulated in group AS ( P<0.05). Compared with group AS, the serum cTnI concentration and percentage of myocardial infarct volume were significantly increased, and expression of SphK1, S1P and p-NF-κB p65 in myocardial tissues was up-regulated in group AKS ( P<0.05). Conclusion:SphK1/S1P signaling pathway is involved in adiponectin-induced restoration of attenuation of myocardial I/R injury by sevoflurane postconditioning in diabetic rats.

Objective: To explore the mediating effect of self-efficacy between mindfulness and self-esteem. Methods: In this study, 400 junior school students from a middle school in Jiangxi Province was recruited and complete mindful self scale, general self-efficacy scale and self-esteem scale. Results: The scores of mindfulness, self-efficacy, self-esteem were (63.89±9.12), (22.82±4.83) and (26.14±4.43), respectively. Mindfulness and its four dimensions (self-insight, self-acceptance, self-compassion and non-persistence) were significantly positively correlated with self-esteem (r=0.18-0.53, all P<0.01). Mindfulness and its three dimensions (self-insight, self-compassion and non-persistence) were significantly positively correlated with self-efficacy (r=0.22-0.39, all P<0.01). Self-efficacy and self-esteem were significantly positively correlated (r=0.82, P<0.01). Mindfulness positively predicted self-efficacy (β=0.38, P<0.01), self-efficacy positively predicted self-esteem (β=0.74, P<0.01), and mindfulness positively predicted self-esteem (β=0.25, P<0.01). That was, self-efficacy partially mediated the relationship between mindfulness and self-esteem. The mediating effect value was 0.28, accounting for 52.83% of the total effect. Conclusion Mindfulness not only directly affects adolescents' self-esteem, but also influences adolescents' self-esteem through self-efficacy.