Logopenic progressive aphasia (LPA) is a special type of atypical Alzheimer's disease (AD) which is easy to be misdiagnosed and its treatment remains to be explored. This paper reports a 59-year-old female with the main symptoms of speech impairment and cognitive decline. Her speech impairment is characterized by slow speech speed, poor fluency, frequent pause in finding words, nominative aphasia, low speech volume, normal pronunciation and intonation, simple syntax, no grammatical errors, obstacles to understand and retell sentences, and the reserved understanding and retelling of words. Together with the blood and cerebrospinal fluid test, electroencephalogram, magnetic resonance imaging, 18F-flurodeoxyglucose positron emission computed tomography, and clinical manifestations, the case was diagnosed with LPA. After being treated with repetitive transcranial magnetic stimulation and speech and language therapy training for 10 times combined with Donepezil treatment, the patient had improvement over her speech and cognitive function but sometimes still had difficulty in acquiring words. Through case analysis and literature review, this article discusses the gains and losses in the diagnosis and treatments of this case, which may provide new ideas for the diagnosis and treatments of LPA to clinicians.

Logopenic progressive aphasia (LPA) is a special type of atypical Alzheimer's disease (AD) which is easy to be misdiagnosed and its treatment remains to be explored. This paper reports a 59-year-old female with the main symptoms of speech impairment and cognitive decline. Her speech impairment is characterized by slow speech speed, poor fluency, frequent pause in finding words, nominative aphasia, low speech volume, normal pronunciation and intonation, simple syntax, no grammatical errors, obstacles to understand and retell sentences, and the reserved understanding and retelling of words. Together with the blood and cerebrospinal fluid test, electroencephalogram, magnetic resonance imaging, 18F-flurodeoxyglucose positron emission computed tomography, and clinical manifestations, the case was diagnosed with LPA. After being treated with repetitive transcranial magnetic stimulation and speech and language therapy training for 10 times combined with Donepezil treatment, the patient had improvement over her speech and cognitive function but sometimes still had difficulty in acquiring words. Through case analysis and literature review, this article discusses the gains and losses in the diagnosis and treatments of this case, which may provide new ideas for the diagnosis and treatments of LPA to clinicians.