Objective To analyze the current status,hotspots,and development trends of granulocyte-macrophage colony stimulating factor(GM-CSF)in immune-inflammatory response based on bibliometric analysis.Methods The Web of Science Core Collection database was utilized to retrieve relevant literatures from Jan.1,1990 to Jan.1,2024,and CiteSpace was applied to visualize and analyze the data.Results A total of 1219 GM-CSF in immunoinflammation related papers were included,and the number of publications was on the rise overall.The number of publications in the United States ranked the first in the world with 445 articles.The institution with the highest number was the University of Melbourne 25 articles.The authors tied for the first place were Jordana M and Becher B(10 articles for each),and the author with the highest citation count was Hamilton JA 128 times;the most cited journal was Journal of Immunology 986 times,and the high frequency keywords related to GM-CSF in immunoinflammation were mainly obtained on inflammation,dendritic cell,T cell,etc.The hotspots of research in recent years are focused on immunity and microglia.Conclusion The research of GM-CSF in immuno-inflammation continues to deepen,and its academic influence is gradually broadened.The future research direction lies in exploring the mechanism of GM-CSF in immunoinflammation and targeted therapy.