Objective To investigate the causal relationship between 41 inflammatory factors and hepatocellular carcinoma(HCC).Methods A two-sample Mendelian randomization(MR)analysis was conducted using genome-wide association study(GW AS)data from the UK Biobank(GCST90043858,n=456 348)and a Finnish population-based GW AS dataset of 41 inflammatory factors(n=8 293).Genetic variants significantly associated with the 41 inflammatory factors were selected as instrumental variables(IVs).The inverse-variance weighted(IVW)method was used as the primary analysis,supplemented by MR Egger regression,weighted median method,and pleiotropy tests to ensure the robustness of the results.Results Genetically predicted IL-5(OR:2.15,95％CI:1.05-4.39,P=0.036)and IL-17(OR:3.35,95％CI:1.36-8.25,P=0.008)were significantly associated with an increased risk of liver cancer.Conclusion IL-5 and IL-17 exhibit a causal relationship with hepatocellular carcinoma risk,suggesting their potential as biomarkers for liver cancer.Targeting inflammatory signaling pathways may provide novel strategies for the prevention and treatment of HCC.

Objective To investigate the causal relationship between 41 inflammatory factors and hepatocellular carcinoma(HCC).Methods A two-sample Mendelian randomization(MR)analysis was conducted using genome-wide association study(GW AS)data from the UK Biobank(GCST90043858,n=456 348)and a Finnish population-based GW AS dataset of 41 inflammatory factors(n=8 293).Genetic variants significantly associated with the 41 inflammatory factors were selected as instrumental variables(IVs).The inverse-variance weighted(IVW)method was used as the primary analysis,supplemented by MR Egger regression,weighted median method,and pleiotropy tests to ensure the robustness of the results.Results Genetically predicted IL-5(OR:2.15,95％CI:1.05-4.39,P=0.036)and IL-17(OR:3.35,95％CI:1.36-8.25,P=0.008)were significantly associated with an increased risk of liver cancer.Conclusion IL-5 and IL-17 exhibit a causal relationship with hepatocellular carcinoma risk,suggesting their potential as biomarkers for liver cancer.Targeting inflammatory signaling pathways may provide novel strategies for the prevention and treatment of HCC.

Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset,severe conditions,a high degree of malignancy,and an extremely poor prognosis.Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma,and the glucose metabolism pathway of cholangiocarcinoma cells will be re-edited in the process of rapid proliferation to produce a large amount of energy for their own needs.Traditional Chinese medicine has unique advantages in the treatment of cholangiocarcinoma,and studies have shown that the active components of traditional Chinese medicine can inhibit the development and progression of cholangiocarcinoma by regulating glucose metabolism.This article reviews the characteristics of glucose metabolism in cholangiocarcinoma and the role of the active components of traditional Chinese medicine in regulating glucose metabolism against cholangiocarcinoma,in order to provide new ideas for the treatment of cholangiocarcinoma.

Objective To explore the influence of TAC protocol (pirarubicin,cyclophosphamide and docetaxel) and AC-T protocol (pirarubicin,cyclophosphamide and sequential docetaxel) on T lymphocytes cell subsets (included CD3+ T cells,CD3+ CD4+ T cells,CD3+ CD8+ T cells,CD3+ CD4+/CD3 + CD8+),natural killer (NK) cells and part of the quality of life in the peripheral blood of patients.Methods A total of 66 patients with breast cancer included 31 cases for TAC protocol (6 cycles of chemotherapy) and 35 cases for AC-T protocol(8 cycles of chemotherapy).Collected respectively before and after the last chemotherapy of peripheral blood,used flow cytometry technique to detect the proportion of T cell subsets and NK cells in peripheral blood,and compared the change of the part of the quality of life before and after chemotherapy.Results After chemotherapy of total of 66 patients CD3+ T cells,CD3+ CD4+T cells and NK cells of peripheral blood ((68.58± 11.03) ％,(33.53 ± 8.84) ％,(18.27 ± 10.65) ％) significantly lower than before chemotherapy ((74.03±13.04)％,(38.42±9.79)％,(19.83± 10.19)％),the differences were statistically significant(t =4.296,3.387,4.092,P＜ 0.05).Grouping was TAC protocol with AC-T,T cell subsets and NK cells before chemotherapy differences had no statistical significance.But after chemotherapy,CD3+ T cells,CD3+ CD4+T cells,CD3+CD8+ T cells and Karnofky score((64.63±10.01)％,(31.19±7.41)％,(24.66±7.40)％,(68.63± 5.100)％) of peripheral blood on TAC protocol were more decreased than AC-T protocol((72.29± 10.78)％,(35.74± 9.60) ％,(30.15 ± 11.12) ％,(77.29 ± 4.58) ％),the differences were statistically significant (t =2.99,2.15,2.35,2.237,P＜0.05).CD3+ CD4+/CD3+ CD8+ and NK cells were also decreased,but without statistical significance.The body quality of 66 patients was slightly increased after chemotherapy,but without statistical significance.Conclusion The body's immune function and the part of quality of the breast cancer patient's life have declined by chemotherapy drugs in varying degrees.Compared TAC,AC-T protocol has less influence on the immunological function and the part of living quality of patients with breast cancer.