During the progression of ischemic stroke,cells experience oxidative stress and intracellular energy depletion,triggering the dynamic assembly and disassembly of stress granules.Stress granules may have a dual role in ischemic stroke.In the ultra-early reperfusion period(6-36 h),under acute stress,the stress granules may inhibit neuronal apoptosis and exert neuroprotective effects through reversible liquid-liquid phase separation.In contrast,in the acute reperfusion period(36 h to 2 weeks),under prolonged stress,pathological stress granules may accumulate through liquid-solid phase transition,leading to neuronal dysfunction and inducing ischemic stroke sequelae such as motor and cognitive impairments.This article reviewed the mechanisms of stress granules dynamic phase transitions during ischemic stroke and their effects on neurons,aiming to provide references and insights for future stress granule-targeted interventions for ischemic stroke and its sequelae.

Objective To investigate the impact of a multi-dimensional nursing intervention model on the quality of life and complications of patients undergoing hemofiltration in the intensive care unit(ICU).Methods A total of 100 patients who underwent hemofiltration and were admitted to the department of intensive care medicine of Armed Police Special Medical Center from June 2021 to June 2023 were enrolled as study objectives.Based on nursing methods,the patients were divided into an experimental group and a control group,with 50 cases in each group.The control group received routine nursing intervention,while the experimental group received multi-dimensional nursing intervention.The differences between the two groups were compared in terms of anxiety and depression,sleep quality,quality of life,nursing satisfaction,and incidence of adverse reactions.Results After receiving nursing care,the self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)score,and Pittsburgh sleep quality index(PSQI)score of both groups were significantly lower than those before nursing,while the generic quality of life inventory-74(GQOLI-74)score was significantly higher than before nursing.Moreover,the experimental group showed significantly lower SDS,SAS,and PSQI scores than the control group(SDS score:34.24±4.19 vs.40.24±4.43,SAS score:41.20±4.33 vs.50.10±5.02,PSQI score:sleep quality was 0.90±0.23 vs.1.55±0.51,sleep latency was 0.47±0.20 vs.0.83±0.34,sleep duration was 1.03±0.21 vs.1.78±0.55,sleep efficiency was 0.73±0.23 vs.1.12±0.21,all P<0.05).The GQOLI-74 scores in the experimental group were higher than those in the control group(somatic function was 64.34±6.93 vs.52.33±5.83,psychological function was 60.24±5.34 vs.54.29±5.88,material life was 64.22±6.24 vs.53.18±5.13,social function was 63.54±5.19 vs.54.10±4.24,all P<0.05).Nursing satisfaction in the experimental group was significantly higher than that in the control group[98.00%(49/50)vs.78.00%(39/50),P<0.05],and the incidence of adverse reactions was significantly lower[6.00%(3/50)vs.22.00%(11/50),P<0.05].Conclusion Implementing a multidimensional nursing intervention for ICU patients undergoing hemofiltration can achieve favorable nursing outcomes.It not only helps reduce the incidence of related complications but also effectively improves patients'quality of life and enhances their satisfaction.

During the progression of ischemic stroke,cells experience oxidative stress and intracellular energy depletion,triggering the dynamic assembly and disassembly of stress granules.Stress granules may have a dual role in ischemic stroke.In the ultra-early reperfusion period(6-36 h),under acute stress,the stress granules may inhibit neuronal apoptosis and exert neuroprotective effects through reversible liquid-liquid phase separation.In contrast,in the acute reperfusion period(36 h to 2 weeks),under prolonged stress,pathological stress granules may accumulate through liquid-solid phase transition,leading to neuronal dysfunction and inducing ischemic stroke sequelae such as motor and cognitive impairments.This article reviewed the mechanisms of stress granules dynamic phase transitions during ischemic stroke and their effects on neurons,aiming to provide references and insights for future stress granule-targeted interventions for ischemic stroke and its sequelae.

Objective To investigate the impact of a multi-dimensional nursing intervention model on the quality of life and complications of patients undergoing hemofiltration in the intensive care unit(ICU).Methods A total of 100 patients who underwent hemofiltration and were admitted to the department of intensive care medicine of Armed Police Special Medical Center from June 2021 to June 2023 were enrolled as study objectives.Based on nursing methods,the patients were divided into an experimental group and a control group,with 50 cases in each group.The control group received routine nursing intervention,while the experimental group received multi-dimensional nursing intervention.The differences between the two groups were compared in terms of anxiety and depression,sleep quality,quality of life,nursing satisfaction,and incidence of adverse reactions.Results After receiving nursing care,the self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)score,and Pittsburgh sleep quality index(PSQI)score of both groups were significantly lower than those before nursing,while the generic quality of life inventory-74(GQOLI-74)score was significantly higher than before nursing.Moreover,the experimental group showed significantly lower SDS,SAS,and PSQI scores than the control group(SDS score:34.24±4.19 vs.40.24±4.43,SAS score:41.20±4.33 vs.50.10±5.02,PSQI score:sleep quality was 0.90±0.23 vs.1.55±0.51,sleep latency was 0.47±0.20 vs.0.83±0.34,sleep duration was 1.03±0.21 vs.1.78±0.55,sleep efficiency was 0.73±0.23 vs.1.12±0.21,all P<0.05).The GQOLI-74 scores in the experimental group were higher than those in the control group(somatic function was 64.34±6.93 vs.52.33±5.83,psychological function was 60.24±5.34 vs.54.29±5.88,material life was 64.22±6.24 vs.53.18±5.13,social function was 63.54±5.19 vs.54.10±4.24,all P<0.05).Nursing satisfaction in the experimental group was significantly higher than that in the control group[98.00%(49/50)vs.78.00%(39/50),P<0.05],and the incidence of adverse reactions was significantly lower[6.00%(3/50)vs.22.00%(11/50),P<0.05].Conclusion Implementing a multidimensional nursing intervention for ICU patients undergoing hemofiltration can achieve favorable nursing outcomes.It not only helps reduce the incidence of related complications but also effectively improves patients'quality of life and enhances their satisfaction.