Cancer is a group of chronic diseases caused by a combination of genetic and environmental factors.Immune cells play a vital role in the regulation of tumor diseases.Recently,innate lymphoid cells(ILCs)have been found to have an important regu-latory role in the tumor microenvironment.ILCs are tissue resident immune cells located mainly in the mucosa and first barrier organs and have been extensively studied for defense against pathogenic invasion,lymphatic development and tissue repair.The role of ILCs in tumor immunity has received increasing attention in recent years.Among the various subpopulations of ILCs cells,the regulation of ILC3s in tumor immunity is the most controversial.Therefore,we summarized the role of ILC3s in tumor immunity by combining rele-vant studies on the involvement of ILC3s in tumor immune regulation in recent years.

Cancer is a group of chronic diseases caused by a combination of genetic and environmental factors.Immune cells play a vital role in the regulation of tumor diseases.Recently,innate lymphoid cells(ILCs)have been found to have an important regu-latory role in the tumor microenvironment.ILCs are tissue resident immune cells located mainly in the mucosa and first barrier organs and have been extensively studied for defense against pathogenic invasion,lymphatic development and tissue repair.The role of ILCs in tumor immunity has received increasing attention in recent years.Among the various subpopulations of ILCs cells,the regulation of ILC3s in tumor immunity is the most controversial.Therefore,we summarized the role of ILC3s in tumor immunity by combining rele-vant studies on the involvement of ILC3s in tumor immune regulation in recent years.

OBJECTIVE: To investigate the effect of bone marrow stromal cell glycosyltransferase B4GALT1 expression on hematopoietic cell proliferation and its upstream regulation mechanism. METHODS: B4GALT1 was overexpressed in human bone marrow stromal cell line HS5, which was then co-cultured with acute myeloid leukemia cell line KG1a. And its effect on hematopoietic cell proliferation was detected by flow cytometry. Dual luciferase reporter assay, real-time PCR and Western blot were used to predict and validate upstream transcription factors that regulate stromal cell B4GALT1 expression. RESULTS: Overexpression of B4GALT1 in HS5 significantly promoted the proliferation of KG1a in the co-culture system. B4GALT1 expression in stromal cells positively correlated with upstream c-Jun expression, which was verified by JNK/c-Jun inhibitors. CONCLUSION The differential expression of glycosyltransferases and their corresponding glycosylation in the hematopoietic microenvironment play an important role.

Objective To assess the effects of absorbable biomedical membrane-embedded intrauterine device ( IUD) in prevention of recurrence after hysteroscopic adhesiolysis for severe intrauterine adhesions ( IUA ) .Methods A prospective study was carried out among 125 patients who underwent hysteroscopic adhesiolysis for severe IUA from February 2013 to January 2015.Foley catheter was placed immediately after surgery and removed 7 days later.Then patients were randomly divided into three groups:group A (40 cases) received round IUD insertion after catheter removal;froup B (41 cases) received IUD placement and intrauterine injection of sodium hyaluronate; group C ( 44 cases ) received absorbable biomedical membrane-embedded IUD insertion.All patients received two artificial cycles ( oral estradiol valerate, 9 mg/d) the first day after surgery.Hysteroscopy was carried out two months later to assess the repair of endometrium.Patients who were cured or whose condition was greatly improved received three-dimensional transvaginal ultrasound examination in the first natural cycle.Thickness of endometrium, uterine volume and blood flow index were compared.Results Cure rate and effective rate in group C were significantly higher than that in groups B and A [43%(19/44) vs.22%(9/41) and 20%(8/40), χ2 =6.89,P=0.03, 86%(37/44) vs.56%(26/41) and 65%(23/40), χ2 =9.78, P =0.01].The improvement rate of menstruation was higher in group C compared with groups B and A [84%(37/44) vs. 63%(26/41)and 58%(23/40),χ2 =7.73, P=0.02].Average endometrium thickness, uterine volume and blood flow index were also significantly improved in Group C[(8.4 ±1.1) vs.(7.2 ±1.5) and (7.6 ± 1.1) mm, F=5.42,P=0.01,(4.3 ±0.3) vs.(3.9 ±0.4) and (4.0 ±0.6) cm3 ,F=7.12,P=0.00, 28.0 ±4.0 vs.24.6 ±4.7 and 23.4 ±4.0,F =5.40,P =0.01] .No significantly differences were observed between group B and group A in terms of the above indices.Conclusion Insertion of absorbable biomedical membrane embedded-IUD has a good therapeutic effect and can better prevent adhesion recurrence in patients with severe intrauterine adhesion after adhesiolysis.