Objective To explore the risk factors for clinical severity in patients with hypertriglyceridemic acute pancreatitis(HTG-AP).Methods A retrospective cohort study was conducted to collect the clinical data of HTG-AP patients admitted to the First Hospital of Putian City from June 2022 to December 2023.Patients were divided into a non-severe group(132 cases)and a severe group(22 cases)according whether they developed complications such as organ dysfunction and pancreatitcs necrosis.The differences in baseline characteristics between the two groups were compared,such as general data[including gender,age,body mass index(BMI),history of hypertension and diabetes],laboratory examination indicators[including glycated hemoglobin(HbA1c),white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT),systemic immune-inflammation index(SII),serum albumin(Alb),serum mylase to serum calcium ration(ACR),D-dimer,platelet count(PLT),total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL),and low-density lipoprotein(LDL)].Univariate and multivariate Logistic regression analyses were used to screen for independent risk factors for clinical severity in HTG-AP patients,and the predictive efficacy of various risk factors for clinical severe progression of HTG-AP was evaluated using the receiver operator characteristic curve(ROC curve).Results A total of 154 patients were included,including 131 males and 23 females;the age range was 18-67 years,average was(39.00±8.74)years.A total of 22 patients developed clinical severity,with an incidence rate of 14.3%.There were no statistically significant differences between the two groups in terms of gender,age,BMI,hypertension,diabetes,HbA1c,WBC,CRP,Alb,PLT,TC,TG,HDL,and LDL.Compared with the non-severe group,the levels of PCT,D-dimer,ACR,and SII were significantly higher in the severe group[PCT(μg/L):0.34(0.12,0.49)vs.0.09(0.05,0.35),D-dimer(μg/L):1 010(340,1 790)vs.310(200,700),ACR:201.10(121.71,568.53)vs.61.79(27.99,153.77),SII:2 076.57(1 187.06,3 665.47)vs.1 033.95(717.95,1 466.76),all P<0.05].Multivariate Logistic regression analysis showed that ACR at admission was an independent risk factors for the development of clinical severity in HTG-AP patients(P<0.05).ROC curve analysis indicated that ACR has certain value in predicting clinical severity in HTG-AP area under the curve(AUC)=0.787[95%confidence interval(95%CI)was 0.685-0.890],P<0.001,and when the optimal cut-off value was set at 79.663,its sensitivity was 90.9%and specificity was 58.3%.Conclusion An abnormally elevated ACR at admission in HTG-AP patients is significantly associated with the risk of clinical severity and can be used as potential predictive indicator for early identification of high-risk patients.

Objective:To explore the research hotspots and emerging trends in the field of breast cancer-associated lymphedema, as reflected in the domestic and international literatures.Methods:The bibliometric method was used to retrieve literatures related to breast cancer-associated lymphedema from the Wanfang Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and the core collection of Web of Science, covering the time range from January 1, 2014, to December 31, 2023. CiteSpace 6.3.R3 software was employed for analysis, which involved statistical assessment of the publication volume, authors, countries, and institutions, as well as the identification of highly cited papers. A co-occurrence analysis of keywords was performed, followed by burst analysis and cluster analysis based on the results.Results:A total of 4 419 Chinese-language articles were retrieved from the three Chinese databases, of which 2 888 were included after duplicate removal. The Web of Science Core Collection yielded 2 142 English-language articles. Among the domestic authors, the top three with the highest publication counts were Zhang Lijuan (25 papers), Jia Jie (22 papers), and Zhong Qiaoling (21 papers). In the English-language literatures, the top three authors with the highest number of publications were Singhal D (32 papers), Devoogdt N (27 papers), and Boyages J (27 papers). A total of 76 countries worldwide had conducted research on breast cancer-associated lymphedema, with the United States contributing the most publications (748 papers), followed by China (227 papers). In total, 642 institutions worldwide had publications on this topic, with 385 domestic institutions. The leading domestic institution was Jiangxi Provincial Cancer Hospital (31 papers), while the top foreign institution was Harvard University (118 papers). The Top 10 most cited papers focused on key research areas in breast cancer-associated lymphedema. A total of 359 Chinese keywords and 513 English keywords were included for co-occurrence analysis. The five most frequent Chinese keywords were quality of life, nursing, complications, upper limb function, and risk factors. In the English literatures, the top five most frequent keywords were quality of life, women, survivors, risk factors, and surgery. Cluster analysis of the keywords revealed 16 clusters in the Chinese literatures, with the largest cluster "functional exercise", while 17 clusters were identified in the English literatures, with the largest cluster "lymph node transfer". The five most consistent clusters in Chinese literatures were lymphatic drainage, rehabilitation, functional impairment, evidence-based nursing, and circumferential lymphatics. In recent years, emerging topics in Chinese literatures included lymphatic drainage, breast reconstruction, and pathophysiology. In English literatures, the consistent top clusters were transplantation, node biopsy, morbidity, identification, and randomized trials, with recent emerging topics including obesity, adipose tissue, healing approaches, lymphatic microsurgical preventive healing approach, and anastomosis.Conclusion:The research on breast cancer-related lymphedema both domestically and internationally shows similarities and differences in direction and focus. Common research hotspots across both domestic and international studies include lymphatic drainage, functional exercise, health behaviors, and lymph node transfer. Recent emerging topics in Chinese literatures include lymphatic drainage, breast reconstruction, and pathophysiology. In contrast, English literatures focus more on the areas such as obesity, adipose tissue, healing methods, and lymphatic anastomosis.

Objective To explore the risk factors for clinical severity in patients with hypertriglyceridemic acute pancreatitis(HTG-AP).Methods A retrospective cohort study was conducted to collect the clinical data of HTG-AP patients admitted to the First Hospital of Putian City from June 2022 to December 2023.Patients were divided into a non-severe group(132 cases)and a severe group(22 cases)according whether they developed complications such as organ dysfunction and pancreatitcs necrosis.The differences in baseline characteristics between the two groups were compared,such as general data[including gender,age,body mass index(BMI),history of hypertension and diabetes],laboratory examination indicators[including glycated hemoglobin(HbA1c),white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT),systemic immune-inflammation index(SII),serum albumin(Alb),serum mylase to serum calcium ration(ACR),D-dimer,platelet count(PLT),total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL),and low-density lipoprotein(LDL)].Univariate and multivariate Logistic regression analyses were used to screen for independent risk factors for clinical severity in HTG-AP patients,and the predictive efficacy of various risk factors for clinical severe progression of HTG-AP was evaluated using the receiver operator characteristic curve(ROC curve).Results A total of 154 patients were included,including 131 males and 23 females;the age range was 18-67 years,average was(39.00±8.74)years.A total of 22 patients developed clinical severity,with an incidence rate of 14.3%.There were no statistically significant differences between the two groups in terms of gender,age,BMI,hypertension,diabetes,HbA1c,WBC,CRP,Alb,PLT,TC,TG,HDL,and LDL.Compared with the non-severe group,the levels of PCT,D-dimer,ACR,and SII were significantly higher in the severe group[PCT(μg/L):0.34(0.12,0.49)vs.0.09(0.05,0.35),D-dimer(μg/L):1 010(340,1 790)vs.310(200,700),ACR:201.10(121.71,568.53)vs.61.79(27.99,153.77),SII:2 076.57(1 187.06,3 665.47)vs.1 033.95(717.95,1 466.76),all P<0.05].Multivariate Logistic regression analysis showed that ACR at admission was an independent risk factors for the development of clinical severity in HTG-AP patients(P<0.05).ROC curve analysis indicated that ACR has certain value in predicting clinical severity in HTG-AP area under the curve(AUC)=0.787[95%confidence interval(95%CI)was 0.685-0.890],P<0.001,and when the optimal cut-off value was set at 79.663,its sensitivity was 90.9%and specificity was 58.3%.Conclusion An abnormally elevated ACR at admission in HTG-AP patients is significantly associated with the risk of clinical severity and can be used as potential predictive indicator for early identification of high-risk patients.

Objective:To explore the research hotspots and emerging trends in the field of breast cancer-associated lymphedema, as reflected in the domestic and international literatures.Methods:The bibliometric method was used to retrieve literatures related to breast cancer-associated lymphedema from the Wanfang Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and the core collection of Web of Science, covering the time range from January 1, 2014, to December 31, 2023. CiteSpace 6.3.R3 software was employed for analysis, which involved statistical assessment of the publication volume, authors, countries, and institutions, as well as the identification of highly cited papers. A co-occurrence analysis of keywords was performed, followed by burst analysis and cluster analysis based on the results.Results:A total of 4 419 Chinese-language articles were retrieved from the three Chinese databases, of which 2 888 were included after duplicate removal. The Web of Science Core Collection yielded 2 142 English-language articles. Among the domestic authors, the top three with the highest publication counts were Zhang Lijuan (25 papers), Jia Jie (22 papers), and Zhong Qiaoling (21 papers). In the English-language literatures, the top three authors with the highest number of publications were Singhal D (32 papers), Devoogdt N (27 papers), and Boyages J (27 papers). A total of 76 countries worldwide had conducted research on breast cancer-associated lymphedema, with the United States contributing the most publications (748 papers), followed by China (227 papers). In total, 642 institutions worldwide had publications on this topic, with 385 domestic institutions. The leading domestic institution was Jiangxi Provincial Cancer Hospital (31 papers), while the top foreign institution was Harvard University (118 papers). The Top 10 most cited papers focused on key research areas in breast cancer-associated lymphedema. A total of 359 Chinese keywords and 513 English keywords were included for co-occurrence analysis. The five most frequent Chinese keywords were quality of life, nursing, complications, upper limb function, and risk factors. In the English literatures, the top five most frequent keywords were quality of life, women, survivors, risk factors, and surgery. Cluster analysis of the keywords revealed 16 clusters in the Chinese literatures, with the largest cluster "functional exercise", while 17 clusters were identified in the English literatures, with the largest cluster "lymph node transfer". The five most consistent clusters in Chinese literatures were lymphatic drainage, rehabilitation, functional impairment, evidence-based nursing, and circumferential lymphatics. In recent years, emerging topics in Chinese literatures included lymphatic drainage, breast reconstruction, and pathophysiology. In English literatures, the consistent top clusters were transplantation, node biopsy, morbidity, identification, and randomized trials, with recent emerging topics including obesity, adipose tissue, healing approaches, lymphatic microsurgical preventive healing approach, and anastomosis.Conclusion:The research on breast cancer-related lymphedema both domestically and internationally shows similarities and differences in direction and focus. Common research hotspots across both domestic and international studies include lymphatic drainage, functional exercise, health behaviors, and lymph node transfer. Recent emerging topics in Chinese literatures include lymphatic drainage, breast reconstruction, and pathophysiology. In contrast, English literatures focus more on the areas such as obesity, adipose tissue, healing methods, and lymphatic anastomosis.

Objective To determine the half-effective target effect-site concentration (EC50) of sufentanil inhibiting responses to insertion of Streamlined Liner of the Pharynx Airway (SLIPA) when combined with propofol given by target-controlled infusion (TCI).Methods Twenty-eight patients,aged 35-55 yr,with body mass index＜30 kg/m2,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,scheduled for elective hysteroscopic surgery,were selected.Sufentanil was administered by TCI at a concentration for 4 min,and then propofol was given by TCI at a target effect-site concentration of 4 μg/ml.When the patients lost consciousness (bispectral index value＜60) and the corresponding target effect-site concentrations of two drugs were achieved,SLIPA was inserted.Using the up-and-down sequential trial,the target effect-site concentration of sufentanil was determined according to patient's responses to SLIPA insertion.The initial target effect-site concentration of sufentanil was 0.3 ng/ml,and the ratio between the two successive concentrations was 1.1.The EC50 and 95％ confidence interval of sufentanil inhibiting responses to SLIPA insertion were calculated by using Dixon-Mood formula.Results The EC50 of sufentanil inhibiting responses to SLIPA insertion was 0.17 ng/ml,and the 95％ confidence interval was 0.15-0.19 ng/ml.Conclusion When combined with propofol (target effect-site concentration 4 μg/ml) given by TCI,the EC50 of sufentanil inhibiting responses to SLIPA insertion is 0.17 ng/ml.