Objective:To investigate the disease self-management status of patients with chronic obstructive pulmonary disease (COPD) and its influential factors, providing evidence for the development of effective management strategies.Methods:A total of 483 patients with chronic obstructive pulmonary disease (COPD) who received treatment at Wenshan People's Hospital from April 2023 to April 2024 were included in this study. Their disease self-management status was assessed, and one-way analysis of variance and multiple linear regression analysis were conducted to identify the factors influencing patients' self-management abilities.Results:Among the 483 patients studied, only 2.9% (14/483) showed a complete understanding of their disease, while 21.12% (102/483) had some understanding of how to manage it. Only 34.38% (166/483) of the patients used inhalants outside the hospital as required, of which only 40.96% (68/166) used them regularly as required by doctors, and 60.84% (101/106) of the patients inhaled correctly. One-way analysis of variance and multiple linear regression analysis results showed that the factors affecting patients' self-management included COPD classification, smoking, life satisfaction, disease self-cognition, exercise habits, lung function, and gender ( t = 2.35, -2.22, -5.76, 4.37, -2.22, 5.09, -3.64, all P < 0.05). Conclusions:Patients with COPD exhibit poor disease self-management awareness and medication compliance. Patient's ability to self-manage their disease is associated with COPD classification, lung function, smoking, exercise habits, gender, life satisfaction, and disease self-cognition. Therefore, it is essential to develop appropriate intervention measures based on these factors, focusing on enhancing patients' self-management awareness and abilities to improve their quality of life.

Objective:To construct a continuity of care plan for adolescent fixed orthodontic patients based on the theory of timing, and provide systematic and standardized nursing interventions for adolescent fixed orthodontic patients.Methods:Guided by the theory of timing, preliminary plan items were formulated through literature review and questionnaire survey. Using the Delphi method, 15 experts were consulted for two rounds to determine the continuity of care plan for adolescent fixed orthodontic patients from October to December, 2023.Results:The effective response rates of the two rounds of questionnaires were 15/15, respectively. The expert authority levels were 0.93 and 0.94, and the Kendall harmony coefficients were 0.28 and 0.38, respectively. The differences were statistically significant (both P<0.001). The final established plan included 5 primary indicators, 23 secondary indicators, and 47 tertiary indicators. Conclusions:The continuity of care plan for adolescent fixed orthodontic patients based on the timing theory is reliable and scientific, and can meet the continuity of care needs of patients at different stages, providing reliable clinical basis for carrying out continuity of care.

The role of osteoblast(OB)autophagy in regulating bone metabolism is a research hotspot in the field of biomedicine.OB autophagy can regulate osteoporosis(OP)induced by aging,oxidative stress,estrogen deficiency,and glucocorticoids(GCs)by mediating factors such as run and cysteine rich domain containing Beclin-1 interacting protein(RUBCN),silent information regulator of transcription 1(SIRT1),and osteoprotegerin(OPG).OB autophagy can also regulate OP by activating notch receptor(Notch)and forkhead box protein O subfamily(FoxO),up-regulating the expression of osteogenic transcription factors(such as Runx2 and Osterix),and mediating the amp-activated protein kinase(AMPK),mammalian target of rapamycin complex(mTOR),Wnt,and c-Jun n terminal kinase(JNK)pathways to act on OB and osteoclast(OC)differentiation.Exercise is an important means of improving OP,and its molecular mechanism is closely related to the up-regulation of phosphatidylinositol 3 kinase(PI3K),adenosine monophosphate(AMP),tumor necrosis factor-alpha(TNF-α),and SIRT1 expression.These in turn activate key factors or pathways(including AMPK,mTOR,Wnt,PI3K/protein kinase B(Akt)/mTOR,and nuclear transcription factor-KB(NF-κB)),regulate the expression of downstream target genes(β-catenin,mTOR,FoxO3a and B cell lymphoma-2(Bcl-2))to up-regulate the expression of autophagy factors(Beclin-1,autophagy related genes(ATG),and microtubule-associated protein 1 light chain 3(LC3)),and promote OB autophagy to restore the dynamic balance in the body,thereby regulating bone formation and bone resorption and improving OP.The relationships among exercise,OB autophagy and OP,however,remain unclear and there is currently a lack of systematic reviews.Here we review and analyze the mechanism of OB autophagy in relation to exercise-induced improvements in OP,and provide a new theoretical basis and research ideas for the prevention and treatment of OP.

The role of osteoblast(OB)autophagy in regulating bone metabolism is a research hotspot in the field of biomedicine.OB autophagy can regulate osteoporosis(OP)induced by aging,oxidative stress,estrogen deficiency,and glucocorticoids(GCs)by mediating factors such as run and cysteine rich domain containing Beclin-1 interacting protein(RUBCN),silent information regulator of transcription 1(SIRT1),and osteoprotegerin(OPG).OB autophagy can also regulate OP by activating notch receptor(Notch)and forkhead box protein O subfamily(FoxO),up-regulating the expression of osteogenic transcription factors(such as Runx2 and Osterix),and mediating the amp-activated protein kinase(AMPK),mammalian target of rapamycin complex(mTOR),Wnt,and c-Jun n terminal kinase(JNK)pathways to act on OB and osteoclast(OC)differentiation.Exercise is an important means of improving OP,and its molecular mechanism is closely related to the up-regulation of phosphatidylinositol 3 kinase(PI3K),adenosine monophosphate(AMP),tumor necrosis factor-alpha(TNF-α),and SIRT1 expression.These in turn activate key factors or pathways(including AMPK,mTOR,Wnt,PI3K/protein kinase B(Akt)/mTOR,and nuclear transcription factor-KB(NF-κB)),regulate the expression of downstream target genes(β-catenin,mTOR,FoxO3a and B cell lymphoma-2(Bcl-2))to up-regulate the expression of autophagy factors(Beclin-1,autophagy related genes(ATG),and microtubule-associated protein 1 light chain 3(LC3)),and promote OB autophagy to restore the dynamic balance in the body,thereby regulating bone formation and bone resorption and improving OP.The relationships among exercise,OB autophagy and OP,however,remain unclear and there is currently a lack of systematic reviews.Here we review and analyze the mechanism of OB autophagy in relation to exercise-induced improvements in OP,and provide a new theoretical basis and research ideas for the prevention and treatment of OP.

Objective:To investigate the disease self-management status of patients with chronic obstructive pulmonary disease (COPD) and its influential factors, providing evidence for the development of effective management strategies.Methods:A total of 483 patients with chronic obstructive pulmonary disease (COPD) who received treatment at Wenshan People's Hospital from April 2023 to April 2024 were included in this study. Their disease self-management status was assessed, and one-way analysis of variance and multiple linear regression analysis were conducted to identify the factors influencing patients' self-management abilities.Results:Among the 483 patients studied, only 2.9% (14/483) showed a complete understanding of their disease, while 21.12% (102/483) had some understanding of how to manage it. Only 34.38% (166/483) of the patients used inhalants outside the hospital as required, of which only 40.96% (68/166) used them regularly as required by doctors, and 60.84% (101/106) of the patients inhaled correctly. One-way analysis of variance and multiple linear regression analysis results showed that the factors affecting patients' self-management included COPD classification, smoking, life satisfaction, disease self-cognition, exercise habits, lung function, and gender ( t = 2.35, -2.22, -5.76, 4.37, -2.22, 5.09, -3.64, all P < 0.05). Conclusions:Patients with COPD exhibit poor disease self-management awareness and medication compliance. Patient's ability to self-manage their disease is associated with COPD classification, lung function, smoking, exercise habits, gender, life satisfaction, and disease self-cognition. Therefore, it is essential to develop appropriate intervention measures based on these factors, focusing on enhancing patients' self-management awareness and abilities to improve their quality of life.

Objective:To construct a continuity of care plan for adolescent fixed orthodontic patients based on the theory of timing, and provide systematic and standardized nursing interventions for adolescent fixed orthodontic patients.Methods:Guided by the theory of timing, preliminary plan items were formulated through literature review and questionnaire survey. Using the Delphi method, 15 experts were consulted for two rounds to determine the continuity of care plan for adolescent fixed orthodontic patients from October to December, 2023.Results:The effective response rates of the two rounds of questionnaires were 15/15, respectively. The expert authority levels were 0.93 and 0.94, and the Kendall harmony coefficients were 0.28 and 0.38, respectively. The differences were statistically significant (both P<0.001). The final established plan included 5 primary indicators, 23 secondary indicators, and 47 tertiary indicators. Conclusions:The continuity of care plan for adolescent fixed orthodontic patients based on the timing theory is reliable and scientific, and can meet the continuity of care needs of patients at different stages, providing reliable clinical basis for carrying out continuity of care.

Research on the mechanisms of depression is currently a focus of the field of neuroscience.The degeneration of brain plasticity(e.g.,decrease in volume,structural degradation,and functional disorder of the hippocampus,PFC,and CG)leads to depression.Exercise is an important means of improving the symptoms of depression.Current research confirms the importance of improving the volume,structure,and function of the hippocampus,PFC,and CG,in this process,but related research has focused solely on changes to the volume of certain brain regions or connectivity functions.Thus,we lack a comprehensive understanding of the antidepressant mechanisms that improve brain plasticity with exercise.Therefore,this study aimed to explore the roles of brain plasticity in the occurrence of depression and improvements to depression through exercise,promoting a more comprehensive understanding the role of brain plasticity in depression.We also provide new ideas for exercise intervention in depression.

Oocyte maturation defect is an extremely rare primary infertility, which is characterized by ovum development arrest, oocyte complete fertilization failure, oocyte apoptosis before and after fertilization, and early embryonic development arrest. This case explored the genetic etiology of a primary infertility patient, who had no mature oocyte after two cycles of controlled ovarian hyperstimulation. Peripheral blood samples of the patient were collected for whole exome sequencing, the suspected pathogenic variants were screened by bioinformatics and verified by sanger sequencing on the patient and her parents. Results showed that the patient was found to harbor homozygous variant of the PATL2 gene, namely c.1363C>T (p.Gln455*). Sanger sequencing has verified that the parents are both heterozygous. The mutation of c.1363C>T is a rare pathogenic mutation that had not yet been recorded in HGMD database. In this case, PATL2 gene mutation can cause oocyte maturation arrest, it is recommended to use whole exome sequencing and genetic counseling as soon as possible for these patients, so as to select appropriate treatment.

Robotic-assisted percutaneous coronary intervention (R-PCI) is an innovative way of performing percutaneous coronary intervention (PCI) whereby the operator can manipulate coronary intraluminal guidewires and catheter devices by using remotely controlled technology. Performing tele-R-PCI from a remote location via fifth generation network communication technology has never been reported in China; however, if this were possible, the technique could be used to treat many patients with coronary artery disease who would otherwise not have the opportunity of treatment. The case of a 73-year-old male patient with coronary artery disease who underwent successful tele-R-PCI at 800 km from the operators is presented. Performing long-distance tele-R-PCI in patients with coronary artery disease is feasible with predictably successful outcomes when reliable network connectivity and local cardiac catheterization facilities are present.

Parkinson's disease(PD)is a highly complex neurodegenerative disease,and its pathogenesis is influenced by DNA methylation,histone modification,and non-coding RNA.Research on Parkinson's brain tissue and blood has shown that changes in DNA methylation/histone modification levels and variations in ncRNA and its target genes may trigger neurodegeneration changes in the brain and serve as potential non-invasive biomarkers for PD.Exercise can ameliorate the neurodegenerative diseases caused by aging and PD by reversing epigenetic changes.This article reviews the role of epigenetics in the pathogenesis of PD,explores the benefits of exercise,and provides a theoretical reference for research into improving PD by regulating epigenetics through exercise.