Objective To summarize professor LI Tianwang's medication rules for treating spleen and stomach diseases based on data mining,learn his diagnostic and therapeutic experiences to provide guidance for clinical prescription of traditional Chinese medicine(TCM).Methods A total of 21,159 TCM prescriptions for spleen and stomach diseases treated by professor LI Tianwang in out-patient department from January 2015 to December 2019 were collected and selected.TCM database was established,and drug frequencies were statistically analyzed.Association rule analysis and clus-ter analysis were conducted on the drugs.Results Excluding Gancao,professor LI Tianwang com-monly used 162 TCM herbs(frequency ≥1％)for treating spleen and stomach diseases,with 26 high-frequency herbs(frequency ≥30％).The most frequently used herb was Baizhu,with a usage frequency of 18,692 times.Commonly used herbs included Baizhu,Fuling,Hehuanpi,Dangshen,Chaihu,and Baishao.The results of association rule analysis indicated high associations in herb pairs such as Dangshen-Baizhu,Fuling-Baizhu,Dangshen-Fuling,Baizhu-Fuling,and Meiguihua-Hehuan-pi.Complex network analysis revealed that core drugs included Dangshen,Baizhu,Foshou,Huanglian,Jineijin,Xiangfu,and Hehuanpi.Cluster analysis showed that herb combinations such as Qingpi-Foshou,Zhishi-Houpo,Huanglian-Wuzhuyu-Ganjiang,and Yiyiren-Muxiang-Chenpi-Shanyao were frequently used together.Conclusion Professor LI Tianwang believes that the basic pathogenesis of spleen and stomach diseases involves deficiency mingled with excess.The deficiency syndrome is mainly characterized by spleen deficiency,while the excess syndrome is mainly characterized by liver stag-nation,phlegm-dampness,and qi stagnation.The treatment principles focus on soothing the liver and relieving depression,invigorating the spleen and replenishing qi,and drying dampness and resol-ving phlegm,supplemented by promoting digestion,warming the middle,and lowering adverse qi.

Objective:To investigate the influencing factors of textbook outcomes in liver surgery (TOLS) after radical resection of gallbladder carcinoma.Methods:The retrospective case-control study was conducted. The clinicopathological data of 530 patients who underwent radical resection of gallbladder carcinoma in 15 medical centers, including the First Affiliated Hospital of Army Medical University et al, from January 2014 to January 2020 were collected. There were 209 males and 321 females, aged (61±10)years. Patients underwent radical resection of gallbladder carcinoma, including cholecystectomy, hepatectomy, invasive bile duct resection, and lymph node dissection. Observation indicators: (1) situations of TOLS; (2) influencing factors of TOLS. Measure-ment data with normal distribution were represented as Mean± SD, and comparison between groups was conducted using the independent sample t test. Measurement data with skewed distribution were represented as M( Q1, Q3), and comparison between groups was conducted using the Mann-Whitney U test. Count data were described as absolute numbers or percentages, and comparison between groups was conducted using the chi-square test. Comparison of ordinal data between groups was conducted using the Mann-Whitney U test. The univariate analysis was conducted using the corresponding statistical methods based on data type, and variables with P<0.10 were included in multivariate analysis. Multivariate analysis was conducted using the Logistic stepwise regression model. Results:(1) Situations of TOLS. All 530 patients underwent radical resection of gallbladder carcinoma, and there were 498 cases achieving R 0 resection, 508 cases without ≥grade 2 intra-operative adverse events, 456 cases without postoperative grade B and grade C biliary leakage, 513 cases without postoperative grade B and grade C liver failure, 395 cases without severe com-plications within postoperative 90 days, 501 cases did not being re-admission caused by severe com-plications within postoperative 90 days. Of the 530 patients, 54.53%(289/530) of patients achieved postoperative TOLS, while 45.47%(241/530) of patients did not achieve postoperative TOLS. (2) Influencing factors of TOLS. Results of multivariate analysis showed that American Society of Anesthesiologists classification >grade Ⅱ, preoperative jaundice, T staging as T3?T4 stage, N staging as N2 stage, liver resection as right hemi-hepatectomy, and neoadjuvant therapy were independent factors influencing TOLS in patients undergoing radical resection of gallbladder carcinoma ( odds ratio=2.65, 1.87, 5.67, 5.65, 2.55, 3.34, 95% confidence interval as 1.22?5.72, 1.18?2.95, 2.51?12.82, 2.83?11.27, 1.41?4.63, 1.88?5.92, P<0.05). Conclusion:American Society of Anesthesiologists classification >grade Ⅱ, preoperative jaundice, T staging as T3?T4 stage, N staging as N2 stage, liver resection as right hemi-hepatectomy, and neoadjuvant therapy are independent factors influencing TOLS in patients undergoing radical resection of gallbladder carcinoma.