Cosmetics may be an important source of human exposure to per-and polyfluoroalkyl substances(PFASs),posing risks to human health.In this study,a nontarget screening method for PFASs in cosmetics was developed using ultra-high performance liquid chromatography-high-resolution mass spectrometry(UHPLC-Q-Orbitrap HRMS)based on the Kendrick mass defect(KMD).The sample was extracted by ultrasonic assisted extraction prior to being analyzed by UHPLC-Q-Orbitrap HRMS.Acquisition of HRMS data was achieved in both full scan and data-dependent(Full MS/dd MS2)mode.The data collected by HRMS were imported into an in-lab built R script for processing.Samples retained the mass spectra peaks with KMD values in the range of 0.85-1 or 0-0.15 for in-and out-of-library matching;when KMD deviation(δKMD)<0.001 and CF 2 mass error(δMS)<15 ppm,it was considered as a potential PFASs homologues.According to matches of parent ions(MS),fragment ions(MS2)and retention time(RT)with the in-house built PFASs database,the screened and identified potential PFASs were categorized to 5 confidence levels(CL1-CL5).A total of 15 kinds of PFASs homologues with confidence level of CL3 and above were screened from 13 cosmetics products and 8 cosmetic raw materials,including perfluoroalkyl alcohol,hydroperfluoroalkyl sulfonic acid,chloroperfluoroalkyl sulfonic acid,etc.with concentrations ranging from 1.9 ng/g to 98.1 ng/g.The nontarget screening method could be used to screen and identify PFASs homologues feasibly and therefore provided data basis for management and control of PFASs addition in cosmetics.

With the rapid development of generative artificial intelligence(GAI)technologies,their widespread application in academic research and writing is continuously expanding the boundaries of sci-entific inquiry.However,this trend has also raised a series of ethical and regulatory challenges,inclu-ding issues related to authorship,content authenticity,citation accuracy,and accountability.In light of the growing involvement of AI in generating academic content,establishing an open,controllable,and trustworthy ethical governance framework has become a key task for safeguarding research integrity and maintaining trust within the academic community.This expert consensus outlines ethical requirements across key stages of AI-assisted academic writing-including topic selection,data management,citation practices,and authorship attribution.It aims to clarify the boundaries and ethical obligations surrounding AI use in academic writing,ensuring that technological tools enhance efficiency without compromising in-tegrity.The goal is to provide guidance and institutional support for building a responsible and sustainable research ecosystem.

Objective To explore the application effect of enhanced recovery after surgery(ERAS)strategy in secondary cesarean delivery.Methods A total of 90 puerperae who underwent elective secondary cesarean delivery in our hospital were enrolled and randomly divided into the observation group and the control group,with 45 cases in each group.Puerperae in the observation group adopted ERAS management,and puerperae in the control group adopted routine management.The postoperative recovery indicators,clinical outcome indicators,scores of self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Kolcaba general comfort questionnaire(GCQ)of puerperae between the two groups were compared.Results The obstetric quality of recovery-11(ObsQoR-11)score 24 hours after surgery of puerperae in the observation group was higher than that in the control group(P<0.05),the recovery time of postoperative bowel sounds and first defecating time were shorter than those in the control group(P<0.05),the height of uterine fundus 72 hours after surgery was lower than that in the control group(P<0.05),the incidences of moderate to severe pain at rest and during cough were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of neonatal transfer to the intensive care unit or the incidence of jaundice between the two groups(P>0.05);while the incidences of intraoperative hypotension,nausea and vomiting,chills,and postoperative abdominal distension,nausea and vomiting of puerperae in the observation group were lower than those in the control group(P<0.05),postoperative vaginal bleeding volume within 24 hours was less than that in the control group(P<0.05).After intervention,the SAS,SDS and GCQ scores of puerperae in both groups were lower than those before intervention(P<0.05),and the SAS and SDS scores of puerperae in the observation group were lower than those in the control group(P<0.05),the GCQ score was higher than that in the control group(P<0.05).Conclusion ERAS strategy used for secondary cesarean delivery can improve clinical outcomes and psychological state of puerperae,increase comfort level,and promote postoperative recovery.

With the rapid development of generative artificial intelligence(GAI)technologies,their widespread application in academic research and writing is continuously expanding the boundaries of sci-entific inquiry.However,this trend has also raised a series of ethical and regulatory challenges,inclu-ding issues related to authorship,content authenticity,citation accuracy,and accountability.In light of the growing involvement of AI in generating academic content,establishing an open,controllable,and trustworthy ethical governance framework has become a key task for safeguarding research integrity and maintaining trust within the academic community.This expert consensus outlines ethical requirements across key stages of AI-assisted academic writing-including topic selection,data management,citation practices,and authorship attribution.It aims to clarify the boundaries and ethical obligations surrounding AI use in academic writing,ensuring that technological tools enhance efficiency without compromising in-tegrity.The goal is to provide guidance and institutional support for building a responsible and sustainable research ecosystem.

Objective To explore the application effect of enhanced recovery after surgery(ERAS)strategy in secondary cesarean delivery.Methods A total of 90 puerperae who underwent elective secondary cesarean delivery in our hospital were enrolled and randomly divided into the observation group and the control group,with 45 cases in each group.Puerperae in the observation group adopted ERAS management,and puerperae in the control group adopted routine management.The postoperative recovery indicators,clinical outcome indicators,scores of self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Kolcaba general comfort questionnaire(GCQ)of puerperae between the two groups were compared.Results The obstetric quality of recovery-11(ObsQoR-11)score 24 hours after surgery of puerperae in the observation group was higher than that in the control group(P<0.05),the recovery time of postoperative bowel sounds and first defecating time were shorter than those in the control group(P<0.05),the height of uterine fundus 72 hours after surgery was lower than that in the control group(P<0.05),the incidences of moderate to severe pain at rest and during cough were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of neonatal transfer to the intensive care unit or the incidence of jaundice between the two groups(P>0.05);while the incidences of intraoperative hypotension,nausea and vomiting,chills,and postoperative abdominal distension,nausea and vomiting of puerperae in the observation group were lower than those in the control group(P<0.05),postoperative vaginal bleeding volume within 24 hours was less than that in the control group(P<0.05).After intervention,the SAS,SDS and GCQ scores of puerperae in both groups were lower than those before intervention(P<0.05),and the SAS and SDS scores of puerperae in the observation group were lower than those in the control group(P<0.05),the GCQ score was higher than that in the control group(P<0.05).Conclusion ERAS strategy used for secondary cesarean delivery can improve clinical outcomes and psychological state of puerperae,increase comfort level,and promote postoperative recovery.

Objective To compare the role and importance of fibular fixation in tibiofibular fractures by Meta-analysis.Methods The literature related to the comparison of the efficacy of fixation of the fibula with or without fixation on the treatment of tibiofibular fractures was searched through the databases of China Knowledge Network,Wipu,Wanfang,The Cochrane Li-brary,Web of science and Pubmed,and statistical analysis was performed using RevMan 5.3 software.The rates of malrotation,rotational deformity,internal/external deformity,anterior/posterior deformity,non-union,infection,secondary surgery and op-erative time were compared between the fibula fixation and non-fixation groups.Results A total of 11 publications were includ-ed,six randomised controlled trials and five case-control trials,eight of which were of high quality.A total of 813 cases were in-cluded,of which 383 were treated with fibula fixation and 430 with unfixed fibulae.Meta-analysis results showed that fixation of the fibulae in the treatment of tibiofibular fractures reduced the rates of postoperative rotational deformity[RR=0.22,95％CI(0.10,0.45),P＜0.000 1]and internal/external deformity[RR=0.34,95％CI(0.14,0.84),P=0.02]and promoted fracture heal-ing[RR=0.76,95％CI(0.58,0.99),P=0.04].In contrast,the rates of poor reduction[RR=0.48,95％CI(0.10,2.33),P=0.36],anterior/posterior deformity[RR=1.50,95％CI(0.76,2.96),P=0.24],infection[RR=1.43,95％CI(0.76,2.72),P=0.27],sec-ondary surgery[RR=1.32,95％CI(0.82,2.11),P=0.25],and operative time[MD=10.21,95％CI(-17.79,38.21),P=0.47]were not statistically significant(P＞0.05)for comparison.Conclusion Simultaneous fixation of the tibia and fibula is clinically more effective in the treatment of tibiofibular fractures.

Aim To research the neuroprotective effect of Haikun Shenxi (HKSX) medicated serum on N2a/ App695 cells and the underlying mechanism. Methods HKSX medicated serum was prepared and carbohydrate components in it was analyzed using high performance thin layer chromatography (HPTLC) . N2a/ App695 cells were intervened with HKSX medicated serum, the cytotoxicity of HKSX medicated serum was measured by MTT; AP[_

Objective To observe the curative effect of comprehensive traditional Chinese medicine(TCM)therapy for the treatment of refractory sudden hearing loss(i.e.,suffering sudden hearing loss more than 2 weeks),and to analyze the factors that may affect the prognosis.Methods A retrospective analysis was carried out in 405 hospitalized patients with refractory sudden hearing loss who were treated in the Department of Otorhinolaryngology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine from 2005 to 2022.The patients were all treated by comprehensive TCM therapy including oral administration of Chinese medicine,acupuncture,acupoint seed-pressing application after individualized syndrome differentiation.The overall clinical efficacy was evaluated,and the difference of efficacy in the patients with various courses of disease,degrees of deafness,types of hearing curve,concomitant symptoms and TCM syndrome types,having or not having previous treatment history was analyzed.Results For the 405 patients with refractory sudden hearing loss,the cure rate was 5.7％and the total effective rate was 28.1％.Among the 405 patients,the best efficacy was achieved in the patients with mild hearing loss,low-frequency decline type of hearing curve,and having no previous treatment history,and the differences were statistically significant(P＜0.05 or P＜0.01).There was no significant difference in the efficacy of patients with different courses of disease,with or without concomitant symptoms,or with various syndrome types(P＞0.05).Conclusion The comprehensive TCM therapy has a certain effect on refractory sudden hearing loss.Patients with poor efficacy after conventional western medicine can still benefit from the comprehensive TCM therapy.

Objective:To construct a comprehensive evaluation index system for integrated health management service capacity of the close-knit medical consortium,and to provide an effective evaluation tool for promoting the construction of a close-knit medical consortium in China.Methods:Based on service chain theory,the initial index pool is established from four dimensions of service guarantee,service guidance,service provision and service evaluation through policy analysis,literature reading and field investigation.Delphi method is used to improve the evaluation indicators through two rounds of expert consultation,and the analytic hierarchy process is used to determine the weight of each indicator.Results:The constructed index system consists of 4 first-class indicators,11 second-class indicators and 50 third-class indicators.The weights of service guarantee,service guidance,service provision and service evaluation are 0.133,0.301,0.401 and 0.165 respectively.Conclusions:Based on the service chain theory,this study applies Delphi expert consultation method and the analytic hierarchy process and invites experts in relevant fields to carry out consultation,aiming at constructing a comprehensive evaluation index system for the integrated health management service capacity of the close-knit medical consortium with strong operability and scientific rationality,and providing an effective evaluation tool for promoting the construction of the close-knit medical consortium in China.

Objective: To compare the prognosis of mildly or severely symptomatic patients with obstructive hypertrophic cardiomyopathy (OHCM) who underwent alcohol septal ablation (ASA). Methods: This retrospective study cohort consisted of patients with OHCM who received ASA treatment in Beijing Anzhen Hospital, Capital Medical University from March 2001 to August 2021. These patients were divided into mildly and severely symptomatic groups according to the severity of clinical symptoms. Long-term follow-up was conducted, and the following data were collected: duration of follow-up, postoperatire treatment, New York Heart Association (NYHA) classification, arrhythmia events and pacemaker implantation, echocardiographic parameters, and cause of death. Overall survival and survival free from OHCM-related death were observed, and the improvement of clinical symptoms and resting left ventricular outflow tract gradient (LVOTG) and the incidence of new-onset atrial fibrillation were evaluated. The Kaplan-Meier method and log-rank test were used to determine and compare the cumulative survival rates of the different groups. Cox regression analysis models were used to determine predictors of clinical events. Results: A total of 189 OHCM patients were included in this study, including 68 in the mildly symptomatic group and 121 in the severely symptomatic group. The median follow-up of the study was 6.0 (2.7, 10.6) years. There was no statistical difference in overall survival between the mildly symptomatic group (5-year and 10-year overall survival were 97.0% and 94.4%, respectively) and the severely symptomatic group (5-year and 10-year overall survival were 94.2% and 83.9%, respectively, P=0.405); there was also no statistical difference in survival free from OHCM-related death between the mildly symptomatic group (5-year and 10-year survival free from HCM-related death were 97.0% and 94.4%, respectively) and the severely symptomatic group (5-year and 10-year survival free from HCM-related death were 95.2% and 92.6%, respectively, P=0.846). In the mildly symptomatic group, NYHA classification was improved after ASA (P<0.001), among which 37 patients (54.4%) were in NYHA class Ⅰ, and the resting left ventricular outflow tract gradient (LVOTG) decreased from 67.6 (42.7, 90.1) mmHg (1 mmHg=0.133 kPa) to 24.4 (11.7, 35.6) mmHg (P<0.001). In severely symptomatic group, NYHA classification was also improved post ASA (P<0.001), among which 96 patients (79.3%) improved by at least one NYHA classification, and the resting LVOTG decreased from 69.6 (38.4, 96.1) mmHg to 19.0 (10.6, 39.8) mmHg (P<0.001). The incidence of new-onset atrial fibrillation was similar between the mildly and severely symptomatic groups (10.2% vs. 13.3%, P=0.565). Cox multivariate regression analysis showed that age was an independent predictor of all-cause mortality in OHCM patients post ASA (HR=1.068, 95%CI 1.002-1.139, P=0.042). Conclusions: Among patients with OHCM treated with ASA, overall survival and survival free from HCM-related death were similar between mildly symptomatic group and severely symptomatic group. ASA therapy can effectively relieve resting LVOTG and improve clinical symptoms in mildly or severely symptomatic patients with OHCM. Age was an independent predictor of all-cause mortality in OHCM patients post ASA.
Humans ; Retrospective Studies ; Atrial Fibrillation ; Heart Septum/surgery* ; Treatment Outcome ; Cardiomyopathy, Hypertrophic/surgery*