1.Mechanisms of Macrophage Glycolysis in Regulating Acute Lung Injury and TCM Intervention Strategies Based on Theory of "Spleen Failing to Disperse Essence"
Qian XU ; Maofu ZHANG ; Xiali LIANG ; Guoxiong HAO ; Jingwei LI ; Xiaojie JIN ; Yongqi LIU ; Xiangxia LUO ; Zhiming ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2026;32(18):218-226
Acute lung injury (ALI) is a critical respiratory emergency caused by various non-cardiogenic factors, including severe pulmonary and extrapulmonary infections, lung contusion, and sepsis. Its pathological features are centered on alveolar-capillary barrier dysfunction, uncontrolled inflammatory responses, and impaired alveolar fluid clearance, manifesting as refractory hypoxemia and respiratory distress, with a poor clinical prognosis. Modern studies have revealed that mitochondrial dysfunction and glucose metabolic reprogramming in macrophages, characterized by hyperactivated glycolysis, drive pro-inflammatory polarization and represent a key mechanism leading to excessive inflammatory responses and disease progression in ALI. Therefore, targeting macrophage glycolysis may be a potential therapeutic strategy for ALI. The Plain Questions: Special Discussion on Channels and Vessels in Huangdi's Internal Classic states that "The spleen disseminates essence upward to the lungs". When the spleen fails in transport and transformation, the distribution of refined nutrients becomes disordered, resulting in the endogenous generation of turbid pathogens that obstruct the pulmonary collaterals, causing failure of lung dispersion and descent and leading to dyspneic reversal. This forms the dynamic pathological pattern of ''deficiency in the root with excess in the manifestation'', thereby proposing the core pathogenesis of ALI as ''spleen deficiency with transport dysfunction and turbid pathogens obstructing the lungs''. This process is intrinsically associated with the inflammatory cascade triggered by disordered macrophage glucose metabolism. Taking the theory of ''spleen failing to disperse essence'' as the entry point, the present study systematically elucidates the progressive pathological mechanism of "energy metabolism disorder-cytokine storm'' in ALI from the perspectives of the ''spleen deficiency-turbid obstruction'' pathogenesis and macrophage glycolysis-pro-inflammatory polarization. In addition, we summarize Chinese medicine compound formulas and monomeric components that ''restore spleen transport and eliminate turbid pathogens'', and explore their potential mechanisms in the treatment of ALI by regulating macrophage metabolic phenotypes to improve the state of ''spleen failing to disperse essence''. This provides a molecular basis for elucidating the ''spleen-lung'' energy metabolism dialogue, deepens understanding of the multi-target regulatory mechanisms of herbal prescriptions, and promotes the deep integration of classical theory with modern medicine.
2.Design of the Rolling Type Nasal Feeding Perfusion Apparatus.
Dong YU ; Yonghuan YANG ; Huiqin HU ; Hongjun LUO ; Yunhao FENG ; Xiali HAO
Chinese Journal of Medical Instrumentation 2015;39(5):347-348
At present, the existing problem in nasal feeding perfusion apparatus is laborious and instability. Designing the rolling type perfusion apparatus by using a roller pump, the problem is solved. Compared with the traditional perfusion apparatus, the advantage lies in liquid carrying only need once and simulating human swallowing process. Through testing and verification, the apparatus can be used in nasal feeding perfusion for elderly or patients.
Aged
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Enteral Nutrition
;
instrumentation
;
Humans
;
Nose
;
Surgical Tape
3.Study on Tracheal Intubation's Circular Arc Radius Measuring Method Based on Machine Vision.
Dong YU ; Genchi LI ; Yunhao FENG ; Yonghuan YANG ; Xiali HAO
Chinese Journal of Medical Instrumentation 2015;39(3):206-215
It is difficult to measure the circular arc radius for central angle less than 30 degrees. The existing measuring methods are of low efficiency and big error. Through designing the machine vision system and studying the image detecting method for measurement, It is obtained good results by using the new measurement for tracheal intubation's circular arc radius, Realized a rapid and accurate measurement of the circular arc radius, and expanded the application in the field of machine vision.
Humans
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Imaging, Three-Dimensional
;
instrumentation
;
Intubation
;
Trachea
4.Design of the Rolling Type Nasal Feeding Perfusion Apparatus
Dong YU ; Yonghuan YANG ; Huiqin HU ; Hongjun LUO ; Yunhao FENG ; Xiali HAO
Chinese Journal of Medical Instrumentation 2015;(5):347-348
At present, the existing problem in nasal feeding perfusion apparatus is laborious and instability. Designing the roling type perfusion apparatus by using a roler pump, the problem is solved. Compared with the traditional perfusion apparatus, the advantage lies in liquid carrying only need once and simulating human swalowing process. Through testing and verification, the apparatus can beused in nasal feeding perfusion for elderly or patients.

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