1.Cumulative delivery rate and related factors of infertile women with low anti-Müllerian hormone level during in vitro fertilization and embryo transfer treatment
Yuanhui CHEN ; Tangmiao LUO ; Shaodi ZHANG ; Yan CHEN ; Xiajie HAN ; Cuilian ZHANG
Chinese Journal of Reproduction and Contraception 2021;41(3):206-211
Objective:To explore the cumulative delivery rate and related factors of infertile women with anti-Müllerian hormone (AMH) no more than 1 μg/L during in vitro fertilization and embryo transfer (IVF-ET) treatment. Methods:In this retrospective cohort study, we analyzed 793 infertile women with AMH no more than 1 μg/L and underwent their first IVF-ET treatment in Henan Provincial People's Hospital between July 2016 and February 2018. All the patients were categorized into two groups according to cumulative delivery with at least one live baby or not. Baseline data and outcomes were compared between the two groups. The regression analysis was conducted to identify the independent factors of cumulative delivery rate and clinical outcomes of different age groups were compared.Results:1) The total cumulative delivery rate per start cycle was 23.83% (189/793). There were significant differences in age [33(30,37) years vs. 39(34,43) years], AMH [0.67(0.46,0.87) μg/L vs. 0.51(0.22,0.74) μg/L], antral follicle count (AFC) [6(4,8) vs. 4(2,6)], basal follicle-stimulating hormone (bFSH) [9.11(6.98,11.03) IU/L vs. 11.06(7.75,13.13) IU/L], starting dosage of gonadotropin (Gn) used [225.0(187.5,225.0) IU vs. 225.0(225.0,300.0) IU], total dosage of Gn used [2 475.0(1 800.0,3 137.5) IU vs. 2 100.0(1 575.0,2 850.0) IU], duration of Gn stimulation [10(8,12) d vs. 9(6,11) d], number of oocytes retrieved [5.0(3.0,7.5) vs. 2.5(1.0,4.0)], number of M II oocytes [4(3,6) vs. 2(1,3)] and number of available cleavage embryos [3.0(2.0,4.5) vs.1.0(0,2.0)] between the two groups (all P<0.001). 2) Multivariate logistic regression analysis suggested that age ( OR=0.878, 95% CI=0.846-0.911, P<0.001) was the vital factor of cumulative delivery rate. The cumulative pregnancy rate and the cumulative delivery rate were significantly decreased with age increasing (all P<0.001). And the cancelation rate of group with age more than 40 years was much higher ( P<0.001). Conclusion:Age was the independent influencing factor of cumulative delivery rate. The cumulative delivery rate decreased significantly with age increasing.
2.Cumulative delivery rate and related factors of infertile women with low anti-Müllerian hormone level during in vitro fertilization and embryo transfer treatment
Yuanhui CHEN ; Tangmiao LUO ; Shaodi ZHANG ; Yan CHEN ; Xiajie HAN ; Cuilian ZHANG
Chinese Journal of Reproduction and Contraception 2021;41(3):206-211
Objective:To explore the cumulative delivery rate and related factors of infertile women with anti-Müllerian hormone (AMH) no more than 1 μg/L during in vitro fertilization and embryo transfer (IVF-ET) treatment. Methods:In this retrospective cohort study, we analyzed 793 infertile women with AMH no more than 1 μg/L and underwent their first IVF-ET treatment in Henan Provincial People's Hospital between July 2016 and February 2018. All the patients were categorized into two groups according to cumulative delivery with at least one live baby or not. Baseline data and outcomes were compared between the two groups. The regression analysis was conducted to identify the independent factors of cumulative delivery rate and clinical outcomes of different age groups were compared.Results:1) The total cumulative delivery rate per start cycle was 23.83% (189/793). There were significant differences in age [33(30,37) years vs. 39(34,43) years], AMH [0.67(0.46,0.87) μg/L vs. 0.51(0.22,0.74) μg/L], antral follicle count (AFC) [6(4,8) vs. 4(2,6)], basal follicle-stimulating hormone (bFSH) [9.11(6.98,11.03) IU/L vs. 11.06(7.75,13.13) IU/L], starting dosage of gonadotropin (Gn) used [225.0(187.5,225.0) IU vs. 225.0(225.0,300.0) IU], total dosage of Gn used [2 475.0(1 800.0,3 137.5) IU vs. 2 100.0(1 575.0,2 850.0) IU], duration of Gn stimulation [10(8,12) d vs. 9(6,11) d], number of oocytes retrieved [5.0(3.0,7.5) vs. 2.5(1.0,4.0)], number of M II oocytes [4(3,6) vs. 2(1,3)] and number of available cleavage embryos [3.0(2.0,4.5) vs.1.0(0,2.0)] between the two groups (all P<0.001). 2) Multivariate logistic regression analysis suggested that age ( OR=0.878, 95% CI=0.846-0.911, P<0.001) was the vital factor of cumulative delivery rate. The cumulative pregnancy rate and the cumulative delivery rate were significantly decreased with age increasing (all P<0.001). And the cancelation rate of group with age more than 40 years was much higher ( P<0.001). Conclusion:Age was the independent influencing factor of cumulative delivery rate. The cumulative delivery rate decreased significantly with age increasing.
3.Diagnostic and therapeutic value of color Doppler flow imaging to elderly femoral arterial pseudo aneurysms
Xiuhua CHEN ; Fajin GUO ; Guang XU ; Xiajie HAN ; Mingxiao WU
Chinese Journal of Postgraduates of Medicine 2009;32(11):35-37
Objective To evaluate the value of color Doppler flow imaging (CDFI) in the diagnosis of elderly femoral arterial pseudo aneurysm and treating with ultrasound-guided compression after percutaneous transluminal coronary angioplasty (PTCA). Methods Twenty-six elderly patients who were found a mass and/or vascular murmur in the puncture region were examined by CDFI, and the results of CDFI were proven by clinic and MRI. All pseudo aneurysms were repaired by CDFI guidance to compress simply and/or injecting directly batroxobin into the pseudo aneurysm lumen combined with compression.Results Pseudo aneurysms were diagnosed definitely by CDFI in 26 cases,and the accuracy rate was 100%. Twenty-two cases were repaired with CDFI guidance to compress simply and percutaneously injection of batroxobin into the pseudo aneurysm lumen combined with compression occurred in 3 cases. One case was cured by surgery after failing to be repaired with CDFI guidance. Conclusions CDFI has an important diagnosis value of pseudo aneurysm after PTCA. The method of CDFI guidance compression and batroxobin injection for repairing pseudo aneurysm is simple, safe and effective.

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