Objective To investigate the correlation between coagulation system biomarkers and bone mineral den-sity(BMD)in patients with spinal degenerative diseases.Methods A total of 251 patients who underwent surgical treatment for spinal degenerative diseases at the Department of Spinal Surgery,Beijing Jishuitan Hospital,from March to October 2019,were enrolled in this study.These patients had both BMD data and coag-ulation system test results available.The distribution of coagulation indicators,including prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib),and thrombin time(TT),was analyzed across different gender and BMD groups.Results A retrospective analysis of laboratory coagulation indicators revealed that in male patients,only fibrinogen levels were significantly increased with the reduction of BMD(P＜0.05).PT and APTT did't show significant differences in female patients across BMD groups,but fibrinogen levels increased with the decrease in BMD(P＜0.05).Patients were classified into osteoporosis and non-osteoporosis groups based on their BMD results.Pearson correlation analysis was performed between the binary variable of BMD grouping and patients'coagulation indicators.The results showed a significant negative correlation between BMD grouping and fi-brinogen levels in both genders(P＜0.05).Conclusions Fibrinogen level in patients with spinal degenerative dis-eases significantly increases as BMD decreases,suggesting that fibrinogen may serve as a predictive biomarker for BMD stratification in these patients.

Objective To investigate the value of detection of anti-cyclic peptide containing citrulline (anti-CCP) antibody, rheumatoid factor (RF) and the combined detection of anti-CCP antibody and RF in rheumatoid arthritis (RA) patients. Methods From 2012 to 2014,1 961 patients were divided into three groups:diagnosed RA group(509 patients), not RA group(1 028 patients) and firstly was not diagnosed RA but later was diagnosed RA group (424 patients). The levels of RF and anti-CCP antibody were separately measured by rate nephelometry method and the electrochemical luminescence method. Results The sensitivity of detecting by anti-CCP antibody alone or anti-CCP antibody in combination with RF between RA group and not RA group was not significant difference ( P>0.05), but the specificity between two groups (88.6%vs. 60.4%) was significant difference ( P<0.05). There were significant differences in the sensitivity (81.7% vs. 74.3%) and specificity (88.6% vs. 66.0%) between by using anti-CCP antibody alone and RF alone.In firstly was not diagnosed RA but later was diagnosed RA group, there were significantly difference in sensitivity (98.3%vs. 82.1%) and specificity (91.6%vs. 81.5%) by using anti-CCP antibody alone and RF alone. Conclusion There is important clinical value by using anti-CCP antibody alone for the early diagnosis of RA.