Insomnia disorder is a common disease in acupuncture clinics.There is a tendency for the theory to solidify and lag behind the clinic.In this paper,we examined insomnia disorder from the perspective of acupuncture and moxibustion theory.Based on the general law of acupuncture and moxibustion to recognize the disease,we concerned that the basic understanding of the disease has commonality between ancient and modern medical practitioners,and the theory can be deconstructed as follows:the theory of"yin and yang"is the starting point and the root of the theory,the theory of"spirit regulars the sleep"is the directly related theory,the theory of internal organs is the basis of the disease mechanism,the theory of meridians and acupoints is the key to diagnosis and treatment,and the theory of acupuncture and moxibustion is the key to treatment.The improvement and development of the theory of acupuncture for insomnia disorder can be carried out on this basis.

Insomnia disorder is a common disease in acupuncture clinics.There is a tendency for the theory to solidify and lag behind the clinic.In this paper,we examined insomnia disorder from the perspective of acupuncture and moxibustion theory.Based on the general law of acupuncture and moxibustion to recognize the disease,we concerned that the basic understanding of the disease has commonality between ancient and modern medical practitioners,and the theory can be deconstructed as follows:the theory of"yin and yang"is the starting point and the root of the theory,the theory of"spirit regulars the sleep"is the directly related theory,the theory of internal organs is the basis of the disease mechanism,the theory of meridians and acupoints is the key to diagnosis and treatment,and the theory of acupuncture and moxibustion is the key to treatment.The improvement and development of the theory of acupuncture for insomnia disorder can be carried out on this basis.

Objective To explore the possible safety difference of anti-infective agents with the same generic drug name produced by different manufacturers. Methods Spontaneous Reporting System for Adverse Drug Reactions of Beijing was searched. The reports of adverse drug reactions(ADR)of levofloxacin,azithromycin,moxifloxacin,clindamycin,cefuroxime,etimicin,cefoperazone sulbactam sodium,cefoxitin,ceftriaxone and ornidazole from January 2009 to December 2013 were collected. The number of ADR reports,types of ADR,suspicious drugs which induced ADR,and the manufacturers were recorded. The number of ADR signals was detected by reporting odds ratio(ROR)method. The safety of drugs was evaluated according to the number of signal and the type of ADR. Results A total of 18 366 ADR reports of 10 kinds of anti-infective drugs were collected. The top five ADR′s types were skin and subcutaneous tissue diseases(7 644),gastrointestinal diseases(2 505),systemic diseases and various parts of the site of treatment(1 761),nervous system disease(1 592)and immune system diseases (1 254)successively. The sum of the digits above accounted for 80.3% in total number of 10 kinds of anti-infective drugs ADR reports(14 756/18 366). The drugs which caused the five kinds of ADR were levofloxacin,azithromycin and clindamycin/moxifloxacin mainly. The numbers of ADR signals of evofloxacin,azithromycin,moxifloxacin,clindamycin,cefuroxime,etimicin,cefoperazone sulbactam sodium,cefoxitin,ceftriaxone,and ornidazole which were detected by ROR method were 17,20,1,23,9, 9,20,5,1 and 9,respectively. The ADR types related to ADR signals were 11,12,1,12,6,8,10,5 and 8,respectively. The numbers of manufacturers related to ADR signals were 9,13,1,14,6,9,11,5, 1 and 9,respectively. Conclusions There are some differences in ADR signals and ADR types among the 10 kinds of anti-infective agents with the same generic drug name produced by different manufacturers. It is suggested that there are some differences in safety of the above-mentioned drugs.

Objective To explore the possible safety difference of anti-infective agents with the same generic drug name produced by different manufacturers. Methods Spontaneous Reporting System for Adverse Drug Reactions of Beijing was searched. The reports of adverse drug reactions(ADR)of levofloxacin,azithromycin,moxifloxacin,clindamycin,cefuroxime,etimicin,cefoperazone sulbactam sodium,cefoxitin,ceftriaxone and ornidazole from January 2009 to December 2013 were collected. The number of ADR reports,types of ADR,suspicious drugs which induced ADR,and the manufacturers were recorded. The number of ADR signals was detected by reporting odds ratio(ROR)method. The safety of drugs was evaluated according to the number of signal and the type of ADR. Results A total of 18 366 ADR reports of 10 kinds of anti-infective drugs were collected. The top five ADR′s types were skin and subcutaneous tissue diseases(7 644),gastrointestinal diseases(2 505),systemic diseases and various parts of the site of treatment(1 761),nervous system disease(1 592)and immune system diseases (1 254)successively. The sum of the digits above accounted for 80.3% in total number of 10 kinds of anti-infective drugs ADR reports(14 756/18 366). The drugs which caused the five kinds of ADR were levofloxacin,azithromycin and clindamycin/moxifloxacin mainly. The numbers of ADR signals of evofloxacin,azithromycin,moxifloxacin,clindamycin,cefuroxime,etimicin,cefoperazone sulbactam sodium,cefoxitin,ceftriaxone,and ornidazole which were detected by ROR method were 17,20,1,23,9, 9,20,5,1 and 9,respectively. The ADR types related to ADR signals were 11,12,1,12,6,8,10,5 and 8,respectively. The numbers of manufacturers related to ADR signals were 9,13,1,14,6,9,11,5, 1 and 9,respectively. Conclusions There are some differences in ADR signals and ADR types among the 10 kinds of anti-infective agents with the same generic drug name produced by different manufacturers. It is suggested that there are some differences in safety of the above-mentioned drugs.