Objective:To analyze the clinical features and prognosis of patients with acute cerebral infarction with different variation coefficients of red blood cell distribution width.Methods:A total of 1 080 patients with acute cerebral infarction diagnosed and treated in the First Affiliated Hospital of Xinjiang Medical University from July 2021 to May 2023 were retrospectively selected as the study objects. The coefficient of variation of red blood cell distribution width was determined for all patients, among which 361 patients with the coefficient of variation of red blood cell distribution width was 11.91% to 14.89%(normal group), and 719 patients with the coefficient of variation of red blood cell distribution width was 14.90% to 23.76% (abnormal group). The clinical characteristics and prognosis of patients with acute cerebral infarction with different coefficient of variation of red blood cell distribution width were compared. Spearman test and Pearson test were used to analyze the correlation between the variation coefficient of red blood cell distribution width and clinical characteristics and prognosis of patients with acute cerebral infarction.Results:There were no significant differences in the proportion of cardiac embolism, arteriole occlusion, partial anterior circulation infarction, posterior circulation infarction and lacunar infarction between the two groups ( P>0.05). The proportion of large atherosclerosis, total anterior circulation infarction, recurrent infarction and prognosis grade 4, 5 and 6 in the normal group was lower than those in the abnormal group :48.48% (175/361) vs. 55.22% (397/719), 8.31% (30/361) vs. 96/719 (13.35%), 16.90% (61/361) vs. 25.03% (180/719), 11.91% (43/361) vs. 42.84% (308/719), 5.26% (19/361) vs. 11.68% (84/719), 0.83% (3/361) vs. 7.93% (57/719); the proportion of grade 0, 1 and 2 prognosis in the normal group were higher than that in the abnormal group: 13.85% (50/361) vs. 0.42% (3/719), 21.05% (76/361) vs. 4.17% (30/719), 21.88% (79/361) vs. 4.73% (34/719), there were statistical differences ( P<0.05). There were statistically significant differences in the variation coefficient of red cell distribution width in patients with acute cerebral infarction among different disease inducements, infarct parts, incidence times and prognosis grades ( P<0.05). Spearman test showed that the variation coefficient of red blood cell distribution width was positively correlated with the infarct volume in patients with acute cerebral infarction ( r = 0.591, P<0.05). The results of Pearson test showed that the variation coefficient of red blood cell distribution width was not correlated with the cause of disease and the location of infarction in patients with acute cerebral infarction ( P>0.05), but was positively correlated with the frequency of incidence and prognosis grade ( r = 0.079, 0.402, P<0.05). Conclusions:Higher coefficients of variation of erythrocyte distribution width are associated with larger infarct size, higher risk of recurrence, and worse prognosis in acute cerebral infarction.

Objective:To analyze the clinical features and prognosis of patients with acute cerebral infarction with different variation coefficients of red blood cell distribution width.Methods:A total of 1 080 patients with acute cerebral infarction diagnosed and treated in the First Affiliated Hospital of Xinjiang Medical University from July 2021 to May 2023 were retrospectively selected as the study objects. The coefficient of variation of red blood cell distribution width was determined for all patients, among which 361 patients with the coefficient of variation of red blood cell distribution width was 11.91% to 14.89%(normal group), and 719 patients with the coefficient of variation of red blood cell distribution width was 14.90% to 23.76% (abnormal group). The clinical characteristics and prognosis of patients with acute cerebral infarction with different coefficient of variation of red blood cell distribution width were compared. Spearman test and Pearson test were used to analyze the correlation between the variation coefficient of red blood cell distribution width and clinical characteristics and prognosis of patients with acute cerebral infarction.Results:There were no significant differences in the proportion of cardiac embolism, arteriole occlusion, partial anterior circulation infarction, posterior circulation infarction and lacunar infarction between the two groups ( P>0.05). The proportion of large atherosclerosis, total anterior circulation infarction, recurrent infarction and prognosis grade 4, 5 and 6 in the normal group was lower than those in the abnormal group :48.48% (175/361) vs. 55.22% (397/719), 8.31% (30/361) vs. 96/719 (13.35%), 16.90% (61/361) vs. 25.03% (180/719), 11.91% (43/361) vs. 42.84% (308/719), 5.26% (19/361) vs. 11.68% (84/719), 0.83% (3/361) vs. 7.93% (57/719); the proportion of grade 0, 1 and 2 prognosis in the normal group were higher than that in the abnormal group: 13.85% (50/361) vs. 0.42% (3/719), 21.05% (76/361) vs. 4.17% (30/719), 21.88% (79/361) vs. 4.73% (34/719), there were statistical differences ( P<0.05). There were statistically significant differences in the variation coefficient of red cell distribution width in patients with acute cerebral infarction among different disease inducements, infarct parts, incidence times and prognosis grades ( P<0.05). Spearman test showed that the variation coefficient of red blood cell distribution width was positively correlated with the infarct volume in patients with acute cerebral infarction ( r = 0.591, P<0.05). The results of Pearson test showed that the variation coefficient of red blood cell distribution width was not correlated with the cause of disease and the location of infarction in patients with acute cerebral infarction ( P>0.05), but was positively correlated with the frequency of incidence and prognosis grade ( r = 0.079, 0.402, P<0.05). Conclusions:Higher coefficients of variation of erythrocyte distribution width are associated with larger infarct size, higher risk of recurrence, and worse prognosis in acute cerebral infarction.

To investigate the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang.Methods 316 young acute ischemic stroke patients who were hospitalized in the Neurology Center of the First Affiliated Hospital of Xinjiang Medical University from July 2016 to December 2020 were selected as the young stroke group，and 637 young nonstroke patients hospitalized during the same period were randomly selected As a youth nonstroke group. The medical history and clinical data of all subjects were collected，and the relationship between plasma lipoprotein a concentration and the occurrence of acute ischemic stroke in young people was analyzed. Results The plasma lipoprotein a concentration in the youth stroke group［140.55 （208.88）］was significantly higher than that in the youth nonstroke group［95.00 （151.38）］.Comparing the plasma lipoprotein a concentration of the young stroke group and the young nonstroke group according to ethnicity，whether it is Han，Uygur or Kazakh，the plasma lipoprotein a concentration of the young stroke group is higher than that of the young non stroke group（P<0.05）. Multivariate logistic regression analysis indicated that lipoprotein a may be one of the independent risk factors for acute ischemic stroke in young people in Xinjiang（OR=1.601，95%CI 1.342～1.910，P<0.05）. Further explore the relationship between the concentration of plasma lipoprotein a and the occurrence of acute ischemic stroke in Han，Uygur，and Kazakh youths. It shows that the increase of lipoprotein a level in Han youth is significantly related to the occurrence of acute ischemic stroke in young people. 1.751 （95%CI 1.404～2.183，P<0.05）；with the increase of plasma lipoprotein a concentration，acute deficiency The risk of bloody stroke also further increased. The risk ratio of the study population at the highest quartile level to the study population at the lowest quartile level was 4.948 （95%CI 2.528～9.686，P<0.05）.However，in the Uygur and Kazakhs，there is no correlation between the concentration of lipoprotein a and the occurrence of acute ischemic stroke in young people.Conclusion The concentration of plasma lipoprotein a is associated with the occurrence of acute ischemic stroke in young people in Xinjiang. Further exploring the ethnic differences in the correlation，it is found that the plasma lipoprotein a concentration is closely related to the occurrence of acute ischemic stroke in the Han youth，and there is no correlation between the Uyghur and Kazakh youths.

Objective To evaluate the association between short-term outcomes and collateral circulation status in patients with acute ischemic stroke receiving thrombolysis therapy.Methods Full-text articles published from January 2000 to November 2016 in Cochrane Library,Medline,Embase and Web of Science electronic database were retrieved and their quality was assessed.The association between short-term outcomes and collateral circulation status were analyzed by random-effects models.Results Twenty three studies involving 2 849 patients were included in quantitative synthesis.The results showed that good collateral circulations had a beneficial effect on favorable outcomes at 3 or 6 months (RR =2.26,95％ CI:1.85-2.77,P =0.00),and were also associated with a lower rate of symptomatic intracranial hemorrhage (RR =0.56,95％ CI:0.47-0.67,P ＜ 0.01) and a lower rate of mortality (RR =0.30,95％ CI:0.22-0.40,P ＜ 0.01).Conclusion The baseline collateral cimulation status is associated with the short-term outcomes in patients with acute ischemic stroke receiving thrombolysis therapy.