Objective:To establish a new curriculum concept in the construction of the first-class "obstetrics and gynecology" course, promote curriculum reform and innovation, build high-quality courses with high order, innovation, and challenge, and enhance students' self-learning and deep learning abilities.Methods:A total of 120 undergraduate students in Xiangyang No. 1 People's Hospital Affiliated to Hubei University of Medicine enrolled in 2019 were selected as research subjects. They were randomly divided into three groups of 40 students each. Classroom organization and implementation were carried out using curriculum reshaping+blended online and offline teaching (Group A), online and offline teaching (Group B), and traditional teaching (Group C). The teaching effects of the three teaching methods were evaluated. SPSS 23.0 was used for analysis of variance and t test. Results:The three groups of students showed significant differences in assessment scores; Group A scored higher in theoretical exams, operational norms, communication skills, and team collaboration than Group B and Group C, while Group B scored higher than Group C. A questionnaire survey showed that 38 (95.00%) students in Group A believed that their interest in learning increased, 31 (77.50%) students believed that their learning initiative increased and they could actively participate in teaching rounds, 37 (92.50%) students believed that their ability to combine theory with practice increased, and 30 (75.00%) students believed that their clinical thinking ability was enhanced. The three groups showed significant differences in teaching effect; Group A demonstrated higher scores in teaching attitude, teaching content and methods, teaching effect, and overall impression than Group B and Group C, while Group B showed higher scores than Group C.Conclusions:The construction of first-class "obstetrics and gynecology" course has promoted the reform and innovation of teaching organization, learning methods, and management models, which enables more effective and comprehensive cultivation of students' clinical analysis and deep learning abilities, which is in line with the concept of cultivating high-quality doctors in modern times.

Objective:To establish a new curriculum concept in the construction of the first-class "obstetrics and gynecology" course, promote curriculum reform and innovation, build high-quality courses with high order, innovation, and challenge, and enhance students' self-learning and deep learning abilities.Methods:A total of 120 undergraduate students in Xiangyang No. 1 People's Hospital Affiliated to Hubei University of Medicine enrolled in 2019 were selected as research subjects. They were randomly divided into three groups of 40 students each. Classroom organization and implementation were carried out using curriculum reshaping+blended online and offline teaching (Group A), online and offline teaching (Group B), and traditional teaching (Group C). The teaching effects of the three teaching methods were evaluated. SPSS 23.0 was used for analysis of variance and t test. Results:The three groups of students showed significant differences in assessment scores; Group A scored higher in theoretical exams, operational norms, communication skills, and team collaboration than Group B and Group C, while Group B scored higher than Group C. A questionnaire survey showed that 38 (95.00%) students in Group A believed that their interest in learning increased, 31 (77.50%) students believed that their learning initiative increased and they could actively participate in teaching rounds, 37 (92.50%) students believed that their ability to combine theory with practice increased, and 30 (75.00%) students believed that their clinical thinking ability was enhanced. The three groups showed significant differences in teaching effect; Group A demonstrated higher scores in teaching attitude, teaching content and methods, teaching effect, and overall impression than Group B and Group C, while Group B showed higher scores than Group C.Conclusions:The construction of first-class "obstetrics and gynecology" course has promoted the reform and innovation of teaching organization, learning methods, and management models, which enables more effective and comprehensive cultivation of students' clinical analysis and deep learning abilities, which is in line with the concept of cultivating high-quality doctors in modern times.

Objective: To analyze the survival of newly diagnosed malignant tumors in cancer registration areas of Hubei Province from 2013 to 2015. Methods: From January 1, 2013 to December 31, 2015, all newly diagnosed malignant tumors were collected from cancer registration areas in Hubei Province, and patients were followed up using a combination of active and passive methods. Cancer survival was analyzed using the strs package in Stata software. Observed and expected survival were calculated using the life table and Ederer Ⅱ methods, and the difference in survival rate of patients with different sex, age, urban and rural areas and different cancer species was compared. Results: From 2013 to 2015, 83 987 new malignant tumors were diagnosed in cancer registration areas in Hubei Province, including 45 742 males (54.46%) and 38245 females (45.54%). The overall 5-year relative survival rate was 41.46%, 34.43% for men and 49.63% for women. With the increase of age, the observed survival rate and relative survival rate of patients of different genders showed a decreasing trend. The 5-year relative survival rate of patients with malignant tumors was 47.58% in urban areas and 26.58% in rural areas. The observed survival rate and relative survival rate in rural areas were significantly lower than those in urban areas. The overall 5-year relative survival rates for common malignancies were 20.61% for lung cancer, 15.36% for liver cancer, 22.89% for esophageal cancer, 34.92% for gastric cancer, and 54.87% for colorectal cancer. In addition, the 5-year relative survival rates of common malignant tumors in women were 78.65% for breast cancer and 52.55% for cervical cancer. Conclusions: In Hubei Province, the survival rate of malignant tumors is different among different genders, regions, age groups and cancer species. Prevention and treatment and health education should be strengthened for malignant tumor patients in rural areas and those with high incidence and low survival rate such as liver cancer and lung cancer, and relevant strategies should be formulated according to the gender and age distribution characteristics of different cancer species.
Humans ; Female ; Male ; Liver Neoplasms ; Uterine Cervical Neoplasms/epidemiology* ; Lung Neoplasms ; China/epidemiology* ; Urban Population ; Incidence ; Survival Analysis ; Rural Population ; Registries

Objective: To analyze the survival of newly diagnosed malignant tumors in cancer registration areas of Hubei Province from 2013 to 2015. Methods: From January 1, 2013 to December 31, 2015, all newly diagnosed malignant tumors were collected from cancer registration areas in Hubei Province, and patients were followed up using a combination of active and passive methods. Cancer survival was analyzed using the strs package in Stata software. Observed and expected survival were calculated using the life table and Ederer Ⅱ methods, and the difference in survival rate of patients with different sex, age, urban and rural areas and different cancer species was compared. Results: From 2013 to 2015, 83 987 new malignant tumors were diagnosed in cancer registration areas in Hubei Province, including 45 742 males (54.46%) and 38245 females (45.54%). The overall 5-year relative survival rate was 41.46%, 34.43% for men and 49.63% for women. With the increase of age, the observed survival rate and relative survival rate of patients of different genders showed a decreasing trend. The 5-year relative survival rate of patients with malignant tumors was 47.58% in urban areas and 26.58% in rural areas. The observed survival rate and relative survival rate in rural areas were significantly lower than those in urban areas. The overall 5-year relative survival rates for common malignancies were 20.61% for lung cancer, 15.36% for liver cancer, 22.89% for esophageal cancer, 34.92% for gastric cancer, and 54.87% for colorectal cancer. In addition, the 5-year relative survival rates of common malignant tumors in women were 78.65% for breast cancer and 52.55% for cervical cancer. Conclusions: In Hubei Province, the survival rate of malignant tumors is different among different genders, regions, age groups and cancer species. Prevention and treatment and health education should be strengthened for malignant tumor patients in rural areas and those with high incidence and low survival rate such as liver cancer and lung cancer, and relevant strategies should be formulated according to the gender and age distribution characteristics of different cancer species.
Humans ; Female ; Male ; Liver Neoplasms ; Uterine Cervical Neoplasms/epidemiology* ; Lung Neoplasms ; China/epidemiology* ; Urban Population ; Incidence ; Survival Analysis ; Rural Population ; Registries

Objective:The present research aimed to explore the involvement of ERK signaling pathway in apoptosis of hepatic carcinoma induced by decitabine combined sodium valproate.Methods: HepG2 cell line was incubated with decitabine combined sodium valproate and the inhibition rate was detected by MTT method.The apoptotic related protein and ERK signal pathway proteins were assayed by Real-time PCR or Western blot.Results: The HepG2 cell line was inhibited greatly by decitabine combined sodium valproate medication with an increased expression of Caspase3,Caspase9 and Bax (P<0.05).The expression of Ras,Raf,MEK and ERK1/2 was increased dramatically after incubation with decitabine combined sodium valproate when compared with control group ( P<0.05).Conclusion:Decitabine combined sodium valproate exert a significant inhibition on the proliferation of HepG2 cell line by nor-malizing the abnormal MEK/ERK signaling pathway.