Purpose: We present a case of Uveitis-Glaucoma-Hyphema (UGH) syndrome secondary to intraocular lens (IOL) subluxation and associated Soemmering ring.Case summary: A 56-year-old female presented with recurrent episodes of right eye uveitis, vitritis, and vitreous hemorrhage, along with progressive vision loss that had not responded to treatment at a private clinic. On examination, her best-corrected visual acuity (BCVA) was 0.4, and intraocular pressure (IOP) was elevated at 34 mmHg. Slit-lamp and fundoscopic evaluation revealed a subluxated IOL and an adjacent Soemmering ring in contact with the iris, accompanied by anterior chamber inflammatory cells, hyphema, and vitreous hemorrhage. A diagnosis of UGH syndrome secondary to IOL subluxation was made. The patient underwent pars plana vitrectomy with the removal of the subluxated IOL and Soemmering ring, followed by scleral fixation of a new IOL using the Yamane technique. Postoperative recovery was favorable, with resolution of anterior chamber inflammation. At follow-up, BCVA had improved to 1.0, and IOP had normalized to 14 mmHg without the need for antiglaucoma medications. Conclusions UGH syndrome resulting from IOL subluxation and a Soemmering ring can be managed effectively via timely surgical intervention, restoring visual acuity and normalizing IOP.

Purpose: To report a case of sequential hydrophilic acrylic intraocular lens (IOL) opacification in both eyes following Ahmed valve implantation in a patient with neovascular glaucoma secondary to diabetes.Case summary: A 59-year-old man was referred to our clinic with ocular pain and elevated intraocular pressure (IOP) three months after undergoing bilateral cataract surgery with hydrophilic acrylic IOL implantation. Examination revealed bilateral proliferative diabetic retinopathy and neovascularization of the iris and anterior chamber angle. The IOP measured 24 mmHg in the right eye and 57 mmHg in the left eye. The patient was diagnosed with neovascular glaucoma secondary to diabetes. Due to uncontrolled IOP, Ahmed valve implantation was initially performed in the left eye. Two years later, the patient experienced decreased visual acuity in the left eye, and a round central opacification of the IOL optic was noted. The opacified IOL was explanted, and a new IOL was implanted with scleral fixation. During follow-up, Ahmed valve implantation was also required in the right eye due to progression of neovascular glaucoma. Two years postoperatively, similar pattern of IOL opacification was observed in the right eye, necessitating the same surgical management. Conclusions Hydrophilic acrylic IOL opacification may occur following Ahmed valve implantation, and is potentially related to altered aqueous humor dynamics, pH changes, and chronic inflammatory responses.

Purpose: We evaluated the treatment outcomes of intravitreal 0.625% povidone-iodine (PI) injection in patients with exogenous and endogenous endophthalmitis. Methods: We retrospectively analyzed the medical records of 21 patients (23 eyes) who received intravitreal 0.625% PI injections for endophthalmitis between March 2021 and December 2023. Results: Of the 21 patients, 19 (19 eyes) had exogenous endophthalmitis, with the most common etiology being post-cataract surgery endophthalmitis in 14 eyes (58.3%). The mean number of intravitreal PI injections administered was 1.6 ± 0.7. The mean time to hypopyon resolution was 2.5 ± 2.1 days. Pars plana vitrectomy (PPV) was required in 16 eyes (84.2%), with an average of 1.1 ± 0.5 surgical interventions. The best-corrected visual acuity (BCVA, logMAR) improved significantly from 2.06 ± 0.52 before treatment to 1.00 ± 0.96 after treatment (p < 0.001). Four eyes of two patients with endogenous endophthalmitis received a mean of 2.5 ± 1.0 intravitreal PI injections (range: 2-4). Clinical improvement was observed in all cases. Conclusions Intravitreal 0.625% PI injection appears to be a potentially effective alternative to conventional antibiotic therapy for the treatment of endophthalmitis.

Purpose: This study was performed to evaluate the clinical characteristics, risk factors, and outcomes of unexplained vision loss associated with silicone oil (SO) tamponade in patients undergoing pars plana vitrectomy for rhegmatogenous retinal detachment. Methods: This retrospective, single-center study included patients who experienced unexplained vision loss during SO tamponade or after SO removal between 2016 and 2024. Unexplained vision loss was defined as a best-corrected visual acuity (BCVA) decline of at least two Snellen lines without identifiable secondary causes. Preoperative and postoperative BCVA, intraocular pressure, and retinal imaging parameters-including central macular thickness and ganglion cell-inner plexiform layer (GCIPL) thickness-were analyzed using sweptsource optical coherence tomography. Results: Among 153 patients, eight (5.2%) developed unexplained vision loss. The mean age was 57.4 ± 6.6 years, and 75% were male.The mean duration of SO tamponade was 143.9 ± 27.5 days. In macula-on cases, BCVA significantly declined from 0.30 ± 0.25 preoperatively to 0.84 ± 0.82 after SO removal (p = 0.042). GCIPL thickness also significantly decreased from 73.8 ± 7.4 μm preoperatively to 52.8 ± 16.7 μm after SO removal (p < 0.05), indicating retinal damage despite SO removal. In macula-off cases, BCVA remained similar between the SO tamponade period (0.37 ± 0.06) and after SO removal (0.58 ± 0.10, p = 0.157). The GCIPL thickness also did not significantly change from the SO tamponade period (58.6 ± 11.9 μm) to after SO removal (58.3 ± 13.7 μm, p = 1.0), suggesting a different pathological mechanism was at play in these cases compared to that in macula-on cases. Conclusions Unexplained vision loss following SO tamponade is linked to progressive GCIPL thinning, indicating neurodegeneration.Prolonged SO tamponade may increase the risk of irreversible visual impairment, underscoring the need for careful patient selection, close monitoring, and timely SO removal. Further research is necessary to understand its mechanisms and develop preventive strategies.