Purpose: Improvement of left ventricular (LV) diastolic dysfunction (DD) is known to be a good prognostic factor in patients with heart failure with reduced ejection fraction (EF). In the present study, we investigated the predisposing risk factors affecting the reversibility of LV diastolic filling pattern (DFP) in patients with preserved EF. Materials and Methods: A total of 600 patients with pseudonormal LVDFP and preserved EF who underwent follow-up echocardiography were enrolled between 2011 and 2020. We compared their index and follow-up echocardiography findings and determined the predisposing risk factor affecting the reversibility of LVDFP. Results: Comparing the index and follow-up echocardiography findings showed that 379 (63%) patients had improved to normal or impaired relaxation LVDFP (improved group) and 221 (37%) patients had maintained or worsened LVDFP (unimproved group).The incidence of paroxysmal atrial fibrillation (PAF) was significantly higher in the unimproved group than in the improved group (4.7% vs. 9.5%, p=0.026). After adjustment for relevant clinical risk factors of diastolic dysfunction, PAF was determined to be an independent predisposing risk factor for the unimproved LVDFP (odds ratio: 2.10, 95% confidence interval: 1.06–4.15, p=0.033).Among the parameters of diastolic dysfunction in follow-up echocardiography, the left atrial volume index, mean E/A ratio, and E/e' were significantly improved in patients without PAF but remained in patients with PAF. Conclusion We identified that PAF was an independent predisposing risk factor of the unimproved LVDFP in patients with pseudonormal LVDFP and preserved EF. Therefore, early detection and management of PAF might be required in patients with LVDD and preserved EF to prevent adverse cardiovascular events.

Purpose: Improvement of left ventricular (LV) diastolic dysfunction (DD) is known to be a good prognostic factor in patients with heart failure with reduced ejection fraction (EF). In the present study, we investigated the predisposing risk factors affecting the reversibility of LV diastolic filling pattern (DFP) in patients with preserved EF. Materials and Methods: A total of 600 patients with pseudonormal LVDFP and preserved EF who underwent follow-up echocardiography were enrolled between 2011 and 2020. We compared their index and follow-up echocardiography findings and determined the predisposing risk factor affecting the reversibility of LVDFP. Results: Comparing the index and follow-up echocardiography findings showed that 379 (63%) patients had improved to normal or impaired relaxation LVDFP (improved group) and 221 (37%) patients had maintained or worsened LVDFP (unimproved group).The incidence of paroxysmal atrial fibrillation (PAF) was significantly higher in the unimproved group than in the improved group (4.7% vs. 9.5%, p=0.026). After adjustment for relevant clinical risk factors of diastolic dysfunction, PAF was determined to be an independent predisposing risk factor for the unimproved LVDFP (odds ratio: 2.10, 95% confidence interval: 1.06–4.15, p=0.033).Among the parameters of diastolic dysfunction in follow-up echocardiography, the left atrial volume index, mean E/A ratio, and E/e' were significantly improved in patients without PAF but remained in patients with PAF. Conclusion We identified that PAF was an independent predisposing risk factor of the unimproved LVDFP in patients with pseudonormal LVDFP and preserved EF. Therefore, early detection and management of PAF might be required in patients with LVDD and preserved EF to prevent adverse cardiovascular events.

Purpose: Improvement of left ventricular (LV) diastolic dysfunction (DD) is known to be a good prognostic factor in patients with heart failure with reduced ejection fraction (EF). In the present study, we investigated the predisposing risk factors affecting the reversibility of LV diastolic filling pattern (DFP) in patients with preserved EF. Materials and Methods: A total of 600 patients with pseudonormal LVDFP and preserved EF who underwent follow-up echocardiography were enrolled between 2011 and 2020. We compared their index and follow-up echocardiography findings and determined the predisposing risk factor affecting the reversibility of LVDFP. Results: Comparing the index and follow-up echocardiography findings showed that 379 (63%) patients had improved to normal or impaired relaxation LVDFP (improved group) and 221 (37%) patients had maintained or worsened LVDFP (unimproved group).The incidence of paroxysmal atrial fibrillation (PAF) was significantly higher in the unimproved group than in the improved group (4.7% vs. 9.5%, p=0.026). After adjustment for relevant clinical risk factors of diastolic dysfunction, PAF was determined to be an independent predisposing risk factor for the unimproved LVDFP (odds ratio: 2.10, 95% confidence interval: 1.06–4.15, p=0.033).Among the parameters of diastolic dysfunction in follow-up echocardiography, the left atrial volume index, mean E/A ratio, and E/e' were significantly improved in patients without PAF but remained in patients with PAF. Conclusion We identified that PAF was an independent predisposing risk factor of the unimproved LVDFP in patients with pseudonormal LVDFP and preserved EF. Therefore, early detection and management of PAF might be required in patients with LVDD and preserved EF to prevent adverse cardiovascular events.

Purpose: Improvement of left ventricular (LV) diastolic dysfunction (DD) is known to be a good prognostic factor in patients with heart failure with reduced ejection fraction (EF). In the present study, we investigated the predisposing risk factors affecting the reversibility of LV diastolic filling pattern (DFP) in patients with preserved EF. Materials and Methods: A total of 600 patients with pseudonormal LVDFP and preserved EF who underwent follow-up echocardiography were enrolled between 2011 and 2020. We compared their index and follow-up echocardiography findings and determined the predisposing risk factor affecting the reversibility of LVDFP. Results: Comparing the index and follow-up echocardiography findings showed that 379 (63%) patients had improved to normal or impaired relaxation LVDFP (improved group) and 221 (37%) patients had maintained or worsened LVDFP (unimproved group).The incidence of paroxysmal atrial fibrillation (PAF) was significantly higher in the unimproved group than in the improved group (4.7% vs. 9.5%, p=0.026). After adjustment for relevant clinical risk factors of diastolic dysfunction, PAF was determined to be an independent predisposing risk factor for the unimproved LVDFP (odds ratio: 2.10, 95% confidence interval: 1.06–4.15, p=0.033).Among the parameters of diastolic dysfunction in follow-up echocardiography, the left atrial volume index, mean E/A ratio, and E/e' were significantly improved in patients without PAF but remained in patients with PAF. Conclusion We identified that PAF was an independent predisposing risk factor of the unimproved LVDFP in patients with pseudonormal LVDFP and preserved EF. Therefore, early detection and management of PAF might be required in patients with LVDD and preserved EF to prevent adverse cardiovascular events.

Purpose: Improvement of left ventricular (LV) diastolic dysfunction (DD) is known to be a good prognostic factor in patients with heart failure with reduced ejection fraction (EF). In the present study, we investigated the predisposing risk factors affecting the reversibility of LV diastolic filling pattern (DFP) in patients with preserved EF. Materials and Methods: A total of 600 patients with pseudonormal LVDFP and preserved EF who underwent follow-up echocardiography were enrolled between 2011 and 2020. We compared their index and follow-up echocardiography findings and determined the predisposing risk factor affecting the reversibility of LVDFP. Results: Comparing the index and follow-up echocardiography findings showed that 379 (63%) patients had improved to normal or impaired relaxation LVDFP (improved group) and 221 (37%) patients had maintained or worsened LVDFP (unimproved group).The incidence of paroxysmal atrial fibrillation (PAF) was significantly higher in the unimproved group than in the improved group (4.7% vs. 9.5%, p=0.026). After adjustment for relevant clinical risk factors of diastolic dysfunction, PAF was determined to be an independent predisposing risk factor for the unimproved LVDFP (odds ratio: 2.10, 95% confidence interval: 1.06–4.15, p=0.033).Among the parameters of diastolic dysfunction in follow-up echocardiography, the left atrial volume index, mean E/A ratio, and E/e' were significantly improved in patients without PAF but remained in patients with PAF. Conclusion We identified that PAF was an independent predisposing risk factor of the unimproved LVDFP in patients with pseudonormal LVDFP and preserved EF. Therefore, early detection and management of PAF might be required in patients with LVDD and preserved EF to prevent adverse cardiovascular events.

Objectives: This study aims to examine the differences in spectral analysis of waking electroencephalography (EEG) patterns between patients with moderate to severe obstructive sleep apnea (OSA) experiencing excessive daytime sleepiness (EDS) and matched healthy participants, to gain insights into the neurophysiological underpinnings of daytime impairments. Methods: A cross-sectional analysis was conducted involving 17 patients with moderate to severe OSA confirmed by overnight polysomnography (PSG). These patients had ≥15 per hour apnea–hypopnea index (AHI) and ≥11 Epworth Sleepiness Scale (ESS). EEG recordings were captured within 30 minutes of awakening. A corresponding group of the equal number of age and sex-matched healthy participants was also analyzed for comparative purposes. Spectral analysis of quantitative EEG (qEEG) of patients with OSA compared with that of an equal number of age- and sex-matched healthy participants. Results: The analysis included 17 patients (16 males, average age 57.2 years) with moderate to severe OSA experiencing EDS (mean AHI 38.1±20.5; ESS 14.4±3.2). The patients with OSA exhibited altered sleep architecture during diagnostic PSG, significantly higher EEG delta band power in the frontal regions upon awakening after night sleep, and decreased connection of delta band in frontal area than normal participants (3.78±5.53 vs. 3.22±0.98 μV2, p=0.03). Conclusions The study demonstrated difference in delta activity and connectivity in the frontal area between patients with OSA experiencing EDS and the control group. These findings suggest awakening qEEG in OSA may helpful to guide or enhance understanding of daytime functional impairment and EDS.

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a rare primary headache disorder characterized by severe intractable stabbing headache and accompanying tearing and conjunctival injections. In this report, we present a case of a patient with SUNCT who achieved sustained remarkable improvement more than 6 months following successful treatment with a single session of botulinum toxin A, after being refractory or intolerant to several preventives for 4 months.

Objectives: This study aims to examine the differences in spectral analysis of waking electroencephalography (EEG) patterns between patients with moderate to severe obstructive sleep apnea (OSA) experiencing excessive daytime sleepiness (EDS) and matched healthy participants, to gain insights into the neurophysiological underpinnings of daytime impairments. Methods: A cross-sectional analysis was conducted involving 17 patients with moderate to severe OSA confirmed by overnight polysomnography (PSG). These patients had ≥15 per hour apnea–hypopnea index (AHI) and ≥11 Epworth Sleepiness Scale (ESS). EEG recordings were captured within 30 minutes of awakening. A corresponding group of the equal number of age and sex-matched healthy participants was also analyzed for comparative purposes. Spectral analysis of quantitative EEG (qEEG) of patients with OSA compared with that of an equal number of age- and sex-matched healthy participants. Results: The analysis included 17 patients (16 males, average age 57.2 years) with moderate to severe OSA experiencing EDS (mean AHI 38.1±20.5; ESS 14.4±3.2). The patients with OSA exhibited altered sleep architecture during diagnostic PSG, significantly higher EEG delta band power in the frontal regions upon awakening after night sleep, and decreased connection of delta band in frontal area than normal participants (3.78±5.53 vs. 3.22±0.98 μV2, p=0.03). Conclusions The study demonstrated difference in delta activity and connectivity in the frontal area between patients with OSA experiencing EDS and the control group. These findings suggest awakening qEEG in OSA may helpful to guide or enhance understanding of daytime functional impairment and EDS.

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a rare primary headache disorder characterized by severe intractable stabbing headache and accompanying tearing and conjunctival injections. In this report, we present a case of a patient with SUNCT who achieved sustained remarkable improvement more than 6 months following successful treatment with a single session of botulinum toxin A, after being refractory or intolerant to several preventives for 4 months.

Objectives: This study aims to examine the differences in spectral analysis of waking electroencephalography (EEG) patterns between patients with moderate to severe obstructive sleep apnea (OSA) experiencing excessive daytime sleepiness (EDS) and matched healthy participants, to gain insights into the neurophysiological underpinnings of daytime impairments. Methods: A cross-sectional analysis was conducted involving 17 patients with moderate to severe OSA confirmed by overnight polysomnography (PSG). These patients had ≥15 per hour apnea–hypopnea index (AHI) and ≥11 Epworth Sleepiness Scale (ESS). EEG recordings were captured within 30 minutes of awakening. A corresponding group of the equal number of age and sex-matched healthy participants was also analyzed for comparative purposes. Spectral analysis of quantitative EEG (qEEG) of patients with OSA compared with that of an equal number of age- and sex-matched healthy participants. Results: The analysis included 17 patients (16 males, average age 57.2 years) with moderate to severe OSA experiencing EDS (mean AHI 38.1±20.5; ESS 14.4±3.2). The patients with OSA exhibited altered sleep architecture during diagnostic PSG, significantly higher EEG delta band power in the frontal regions upon awakening after night sleep, and decreased connection of delta band in frontal area than normal participants (3.78±5.53 vs. 3.22±0.98 μV2, p=0.03). Conclusions The study demonstrated difference in delta activity and connectivity in the frontal area between patients with OSA experiencing EDS and the control group. These findings suggest awakening qEEG in OSA may helpful to guide or enhance understanding of daytime functional impairment and EDS.