Objective To explore the value of intravoxel incoherent motion diffusion weighted imaging(IVIM)in preopera-tive diagnosis of microvascular invasion(MVI)in hepatocellular carcinoma(HCC).Methods A retrospective analysis was con-ducted on the imaging data of 38 hepatocellular carcinoma patients who underwent surgical resection at Hunan Medical College General Hospital from 2019 to 2022.According to postoperative pathology results,they were divided into MVI positive group and MVI negative group.The apparent diffusion coefficient(ADC)of DWI parameters,the true diffusion coefficient(D),perfu-sion related diffusion coefficient(D),and perfusion score(f)of IVIM parameters were measured before surgery in HCC pa-tients.The risk factors affecting the occurrence of MVI in HCC were analyzed,and the diagnostic efficacy of subject operating characteristic curve(ROC)was evaluated for MVI.Results The ADC and D values of the MVI positive group were lower than those of the negative group,with statistical differences(both P＜0.05).The area under the D-value curve(AUC),specificity,and sensitivity were 0.741,68％,and 94％,respectively.The area,specificity,and sensitivity under the ADC value curve were 0.714,50％,and 88％,respectively,The area under the curve for the combined diagnosis of MVI by two indicators was 0.832,with a sensitivity of 94％and a specificity of 77％.Conclusion The IVIM parameter D value and DWI parameter ADC value can help to predict microvascular infiltra-tion in hepatocellular carcinoma before surgery,and the diagnostic efficacy of D value is superior to ADC value.IVIM imaging can im-prove the accuracy of preoperative prediction of microvascular invasion in hepatocellular carcinoma.

Objective To explore the value of intravoxel incoherent motion diffusion weighted imaging(IVIM)in preopera-tive diagnosis of microvascular invasion(MVI)in hepatocellular carcinoma(HCC).Methods A retrospective analysis was con-ducted on the imaging data of 38 hepatocellular carcinoma patients who underwent surgical resection at Hunan Medical College General Hospital from 2019 to 2022.According to postoperative pathology results,they were divided into MVI positive group and MVI negative group.The apparent diffusion coefficient(ADC)of DWI parameters,the true diffusion coefficient(D),perfu-sion related diffusion coefficient(D),and perfusion score(f)of IVIM parameters were measured before surgery in HCC pa-tients.The risk factors affecting the occurrence of MVI in HCC were analyzed,and the diagnostic efficacy of subject operating characteristic curve(ROC)was evaluated for MVI.Results The ADC and D values of the MVI positive group were lower than those of the negative group,with statistical differences(both P＜0.05).The area under the D-value curve(AUC),specificity,and sensitivity were 0.741,68％,and 94％,respectively.The area,specificity,and sensitivity under the ADC value curve were 0.714,50％,and 88％,respectively,The area under the curve for the combined diagnosis of MVI by two indicators was 0.832,with a sensitivity of 94％and a specificity of 77％.Conclusion The IVIM parameter D value and DWI parameter ADC value can help to predict microvascular infiltra-tion in hepatocellular carcinoma before surgery,and the diagnostic efficacy of D value is superior to ADC value.IVIM imaging can im-prove the accuracy of preoperative prediction of microvascular invasion in hepatocellular carcinoma.

Objective:To describe the characteristics and change trends of incidence, mortality and disease burden of acute myocardial infarction (AMI) in Qingdao from 2014 to 2020.Methods:We analyzed the incidence data of AMI retrieved from Qingdao Chronic Diseases Surveillance System. The average annual percent change (AAPC) of morbidity and mortality of AMI were evaluated by using Joinpoint log-linear regression model. Disability adjusted life year (DALY) was used to estimate disease burden of AMI in Qingdao.Results:A total of 70 491 AMI cases and 50 832 deaths of AMI occurred in Qingdao from 2014 to 2020. The age-standardized morbidity and mortality were 54.71/100 000 and 36.55/100 000, respectively. During 2014-2020, the AAPC of age-standardized morbidity was 2.86% (95% CI: 0.42%-5.35%), and 4.30% (95% CI: 1.24%-7.45%) in men and 0.78% (95% CI: -0.89%-2.47%) in women, respectively. The log-linear regression model showed that age-standardized morbidity in age groups 30-39, 40-49 years increased rapidly, with the AAPCs of 8.92% (95% CI: 2.23%-16.06%) and 6.32% (95% CI: 3.30%-9.44%), respectively. The trend was also observed in age groups 30-39, 40-49 and 50-59 years in men, with the AAPCs of 11.25% (95% CI: 3.54%-19.54%), 6.73% (95% CI: 2.63%-10.99%) and 6.72% (95% CI: 2.98%-10.60%), respectively. There was no significant change in age-standardized mortality. The DALY rate increased from 7.49/1 000 in 2014 to 8.61/1 000 in 2020, with the AAPC of 1.97% (95% CI: 0.36%-3.60%). Conclusions:The age-standardized morbidity of AMI in men increased in Qingdao, especially in those aged 30-49 years, while age-standardized mortality rate of AMI was relatively stable from 2014 to 2020. The burden of disease of AMI increased in both men and women.

Adolescent ; Adult ; Female ; Hepatitis B e Antigens ; blood ; Hepatitis B, Chronic ; blood ; diagnosis ; drug therapy ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Thymidine ; analogs & derivatives ; therapeutic use ; Treatment Outcome ; Young Adult

Objective To study the clinical characteristics,diagnosis,and treatment of paratyphoid fever A (fever A) complicated with severe kidney damage. Methods The data were retrospectively reviewed.Results The symptoms of poisoning and gastrointestinal symptoms as well as the slightly abnormal urinalysis (proteinuria, hematuria) appeared early, which got worse along with the progression of the disease. The symptoms of urinary system and azotemia appeared in the worst period. After treatment with antibiotic, 4 patients recovered early.Conclusion Paratyphoid fever A can cause severe kidney damage, with non-specific symptoms at the early stage. The seriousness of the abnormal of urine test can't be ignored as those provides the basis for the early diagnosis. The early use of antibiotic is the key to avoid and lessen the serverity of kidney damage.