Objective To investigate the predictive values of interleukin(IL)-6 and IL-10 in the peripheral blood of donors of brain death for delayed graft function(DGF)in kidney transplant recipients.Methods The clinical data and blood samples of 21 donors of brain death and 42 kidney transplant recipients were retrospectively collected.The predictive values of IL-6 and IL-10 in the peripheral blood of donors for DGF were evaluated using the occurrence of DGF as a dependent variable.Results Among the 42 kidney transplant recipients,10 developed DGF.Univariate analysis showed that there were significant differences in the IL-6 and creatinine levels in the donors and cold ischemia time of donor kidney between DGF and non-DGF groups.The receiver operating characteristic curve showed that IL-6 and IL-10 in donor peripheral blood had certain predictive values for DGF in kidney transplant recipients(AUC=0.82,95%CI:0.64-0.99;AUC=0.73,95%CI:0.51-0.95).Despite adjusting for creatinine level and cold ischemia time,IL-6 still has a certain predictive value for DGF.Conclusion IL-6 in the peripheral blood of donors of brain death may be a predictor of DGF in kidney transplant recipients.

Communication with the family members of donors is an integral part of the organ donation and transplantation, and the core of it lies in building trust through interpersonal communication. Every word and deed from the communicator will directly affect the overall impression of family members of potential donors towards organ donation. Regardless of whether or not granted the donation ultimately, family members may share their personal experiences and feelings with friends and relatives around them, which develops a secondary dissemination. Therefore, "the choice of best candidate for communication with family members of organ donation" has been an issue that organ donation practitioners have been working on in clinical practice. Taking into consideration of the experiences from different countries or regions, various advices and practices on this issue have been proposed due to differences in social systems, cultural background, organizational structure, clinical practice, etc. In this paper, we had a discussion on this topic, summarize the difficulties currently encountered in communication with family members and propose corresponding strategies.