Platelet activation plays a crucial role in the pathogenesis of cardiovascular and cerebrovascular diseases and the safety of platelet transfusion. Blood-activating and stasis-resolving Chinese herbs, known for improving blood circulation and eliminating blood stasis, can be classified into four categories: blood-activating and pain-relieving herbs, blood-activating and menstruation-regulating herbs, blood-activating and wound-healing herbs, and blood-breaking and mass-eliminating herbs. Modern research has revealed that these herbs exert antiplatelet activation effects through multiple molecular mechanisms. Key mechanisms include regulating the arachidonic acid metabolic pathway, inhibiting platelet membrane receptor function, influencing intracellular signal transduction, and modulating platelet-vascular endothelial interactions. Compared with conventional antiplatelet drugs, blood-activating and stasis-resolving Chinese herbs offer the advantage of multi-pathway synergistic effects and demonstrate potential value in prolonging platelet storage. This article systematically elaborates on the active monomers and mechanisms of these four categories of Chinese herbs in inhibiting platelet activation, summarizing their multi-target and multi-pathway characteristics, aiming to provide a theoretical basis for the clinical application of these herbs in suppressing platelet activation.

Through the functional combination of relevant departments involved in hospital procurement, to simplify and unify the work process, we establish a standardized procurement system, to realize the pre-procurement budget and approval, power balance, strengthen the fairness and openness of procurement process. By introducing the closed-loop process of in-process supervision to ensure the impartiality of review and post-evaluation control, it comprehensively strengthens the internal control of procurement management, and finally realizes the purpose of strengthening procurement risk prevention and procurement quality management.
Hospitals, Public ; Purchasing, Hospital ; Quality Control ; Research

Objective To investigate the clinical value of early endoscopic intervention in diagnosis and treatment of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB). Methods A retrospective analysis was performed of 150 senile patients with ANVUGIB who were intervened by early endoscopy or selective endoscopy from Janurary 2015 to September 2015. The causes of ANVUGIB were analyzed. The diagnosis rates, success rates of hemostasis, rates of rebleeding, surgery, hemostatic time, blood transfusion volume, hospitalization time, hospitalization cost were compared in early endoscopy group and selective endoscopy group. The quality of life was compared between the two groups by NHP after the patients left hospital for three months. Results Peptic ulcer, gastric cancer, acute hemor-rhagic gastritis were the three major causes of ANVUGIB. The diagnosis rate and successful hemostasis rates of early endoscopy group were significantly higher than that in selective endoscopy group ( < 0.05). The rates of rebleeding and surgery were significantly lower, the blood transfusion volume was reduced, hospitalization time were shorten, and hospitalization cost were lower in early endoscopy group ( < 0.05). The quality of life of early endoscopy group was statistically higher than that in selective endoscopy group ( < 0.05). Conclusion Early endoscopic intervention is safe, effective and identify hemorrhage cause fast in diagnosis and treatment in senile patients with ANVUGIB. It is worthy of widespread promoting.