1.Construction, operational mechanism, and practical dilemmas of a community-integrated medical-nursing-rehabilitation-care service model for the elderly with chronic diseases
Siyu WANG ; Lian CHENG ; Keju WANG ; Wenna WANG ; Zhong ZHANG
Chinese Medical Ethics 2026;39(5):678-687
With the deepening of population aging and the rising prevalence of chronic diseases among the elderly in China, the traditional elderly care models are facing challenges. This paper proposed a community-integrated medical-nursing-rehabilitation-care service model, characterized by “integration, flexibility, community orientation, and demand orientation.” This model optimizes and combines various service resources such as healthcare, elderly care, rehabilitation, and nursing at the community level, providing more comprehensive and targeted services for the elderly with chronic diseases in the community. However, a series of challenges existed in dimensions such as the service integration, benefit distribution, resources and funds, as well as policies and systems, hindering the sustainable development of the community-integrated medical-nursing-rehabilitation-care service model. Future efforts should focus on constructing a more standardized collaborative system, clarifying standards for resource investment and benefit distribution, as well as strengthening policy guidance, financial support, and talent team development.
2.Simultaneous Determination of 6 Components in Chaihuang Tablets by HPLC-DAD
Changling DING ; Junfeng CUI ; Xiaorong SHI ; Yangyang XU ; Wenna CHENG ; Jinjie ZHANG ; Li ZHAO
China Pharmacy 2019;30(11):1477-1481
OBJECTIVE: To establish a method for simultaneous determination of 6 components in Chaihuang tablets, such as baicalin, wogonoside, baicalein, wogonin, saikosaponin a and saikosaponin d in Chaihuang tablets. METHODS: HPLC-DAD method was used to detect 3 batches of Chaihuang tablets from same manufacturers. The determination was performed on Agilent Eclipse XDB-C18 column with mobile phase consisted of acetonitrile-triethylamine phosphate aqueous solution (pH adjusted to 7.0, gradient elution) at flow rate of 1.0 mL/min. The detection wavelengths were set at 210 nm (saikosaponin a, saikosaponin d) and 277 nm (baicalin, wogonoside, baicalein, wogonin). The column temperature was 30 ℃, and sample size was 5 μL. RESULTS: The linear ranges of baicalin, wogonoside, baicalein, wogonin, saikosaponin a and saikosaponin d were 0.379 5-7.590 4 μg, 0.082 96-1.659 2 μg, 0.039 39-0.787 8 μg, 0.040 72-0.814 4 μg, 0.040 45-0.809 0 μg, 0.038 63-0.772 6 μg (all r≥0.999 3), respectively. The limits of detection were 0.008, 0.007, 0.005, 0.005, 0.020 and 0.018 μg/mL. The limits of quantitation were 0.025, 0.022, 0.015, 0.015, 0.060, 0.054 μg/mL. RSDs of precision, reproducibility and stability tests (48 h) were all lower than 1.5% (n=6). Average recoveries were 98.46%, 97.06%, 100.90%, 96.13%, 96.91%, 96.57% (RSD<2.0%, n=6). CONCLUSIONS: Established method is simple, accurate and reproducible for 6 components in Chaihuang tablets, and can be used for quality control of the tablet.
3.Establishment of HPLC Fingerprint and Classification of Chemical Components for Compound Sanhuang Tincture
Changling DING ; Junfeng CUI ; Xuemei ZHANG ; Yong FU ; Qizhong FAN ; Wenna CHENG
China Pharmacist 2017;20(9):1564-1566,1572
Objective:To establish the HPLC fingerprint of ethanol parts of compound Sanhuang tincture ( an anti-infective drug) using high performance liquid chromatography, and analyze the classification of the chemical components. Methods: A Phenomenex Luna C18 (2) (250 mm × 4. 6 mm, 5 μm) column was used. The mobile phase was acetonitrile-0. 05 mol·L-1 aqueous potassium di-hydrogen phosphate solution (22 :78) and the flow rate was 1. 0 ml·min-1 . The DAD detector was used and the detection wavelength was 237 nm. The column temperature was 30 ℃ and the injection volume was 10 μl. Results:The fingerprints of compound Sanhuang tincture were obtained with promising separation degree and the number of theoretical plates. A total of six fingerprint characteristic peaks were identified, and the reproducibility, stability and precision of the method were good. Meanwhile, combined with the informa-tion of retention time of compound medicine, single drug and reference substance, the source of characteristic peak of the effective part of compound Sanhuang tincture was determined. Conclusion:The fingerprints of compound Sanhuang tincture have strong characteris-tics and good reproducibility, which have important reference value for the quality evaluation of ethanol parts of compound Sanhuang tincture.

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