Purpose: This research observed the efficacy and safety of soft tissue expansion combined with recombinant human epidermal growth factor (rhEGF) in repairing second-degree scald scars. Methods: This study conducted a prospective, single-blind, randomized controlled trial. Eighty-four patients with deep second-degree scald scars were evenly divided into the control and observation groups. The control group was treated with soft tissue expansion, and the observation group was additionally treated with rhEGF. The skin expansion and wound healing times were compared. The changes in wound exudate and inflammation around the wound were observed after first-stage surgery. The hydroxyproline (OHP) and collagen I/III ratios were compared during the second stage of surgery.The complications and repair effects during treatment were evaluated. Results: The observation group exhibited lower expansion time, immediate retraction rate, and wound healing time, higher skin expansion rate, higher wound exudate score and inflammation score, higher OHP, lower collagen I/III, lower complication rate, and higher total effective rate than the control group (all P < 0.05). Conclusion Skin soft tissue expansion combined with rhEGF is more effective in repairing second-degree scald scars, which can effectively increase skin expansion area and reduce wound infection and complications.

Migraine is a chronic brain dysfunction disorder characterized by recurrent unilateral or bilateral moderate-to-severe throbbing headaches, often accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a vasodilatory peptide that plays a significant role in the pathogenesis of migraine through mechanisms similar to, yet independent of, calcitonin gene-related peptide. With in-depth research on PACAP′s involvement in migraine pathogenesis, drugs targeting PACAP and its receptors have been progressively developed and entered clinical trials. This article outlines the structure and biological characteristics of PACAP and its receptors, summarizes their roles in different stages of migraine pathogenesis, and discusses their current status and prospects as biomarkers and therapeutic targets for migraine to provide new insights into the mechanisms, diagnosis, and treatment of migraine.

Purpose: This research observed the efficacy and safety of soft tissue expansion combined with recombinant human epidermal growth factor (rhEGF) in repairing second-degree scald scars. Methods: This study conducted a prospective, single-blind, randomized controlled trial. Eighty-four patients with deep second-degree scald scars were evenly divided into the control and observation groups. The control group was treated with soft tissue expansion, and the observation group was additionally treated with rhEGF. The skin expansion and wound healing times were compared. The changes in wound exudate and inflammation around the wound were observed after first-stage surgery. The hydroxyproline (OHP) and collagen I/III ratios were compared during the second stage of surgery.The complications and repair effects during treatment were evaluated. Results: The observation group exhibited lower expansion time, immediate retraction rate, and wound healing time, higher skin expansion rate, higher wound exudate score and inflammation score, higher OHP, lower collagen I/III, lower complication rate, and higher total effective rate than the control group (all P < 0.05). Conclusion Skin soft tissue expansion combined with rhEGF is more effective in repairing second-degree scald scars, which can effectively increase skin expansion area and reduce wound infection and complications.

Purpose: This research observed the efficacy and safety of soft tissue expansion combined with recombinant human epidermal growth factor (rhEGF) in repairing second-degree scald scars. Methods: This study conducted a prospective, single-blind, randomized controlled trial. Eighty-four patients with deep second-degree scald scars were evenly divided into the control and observation groups. The control group was treated with soft tissue expansion, and the observation group was additionally treated with rhEGF. The skin expansion and wound healing times were compared. The changes in wound exudate and inflammation around the wound were observed after first-stage surgery. The hydroxyproline (OHP) and collagen I/III ratios were compared during the second stage of surgery.The complications and repair effects during treatment were evaluated. Results: The observation group exhibited lower expansion time, immediate retraction rate, and wound healing time, higher skin expansion rate, higher wound exudate score and inflammation score, higher OHP, lower collagen I/III, lower complication rate, and higher total effective rate than the control group (all P < 0.05). Conclusion Skin soft tissue expansion combined with rhEGF is more effective in repairing second-degree scald scars, which can effectively increase skin expansion area and reduce wound infection and complications.

Migraine is a chronic brain dysfunction disorder characterized by recurrent unilateral or bilateral moderate-to-severe throbbing headaches, often accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a vasodilatory peptide that plays a significant role in the pathogenesis of migraine through mechanisms similar to, yet independent of, calcitonin gene-related peptide. With in-depth research on PACAP′s involvement in migraine pathogenesis, drugs targeting PACAP and its receptors have been progressively developed and entered clinical trials. This article outlines the structure and biological characteristics of PACAP and its receptors, summarizes their roles in different stages of migraine pathogenesis, and discusses their current status and prospects as biomarkers and therapeutic targets for migraine to provide new insights into the mechanisms, diagnosis, and treatment of migraine.

Objective To explore the related influencing factors of androgenic alopecia(AGA)in young women(FAGA).Methods A total of 296 cases of FAGA initially diagnosed in the dermatology clinic of this hospital from January 2022 to January 2023 were selected as the observation group,and 296 young women without suffering from FAGA in the physical examination of this hospital at the same time were selected as the control group.The clinical data were compared between the two groups and the influencing factors causing FAGA in young women were analyzed.Results The familial inheritance history,often staying up,sleep disor-der,like to eat high carbohydrate food,like to eat high fat food,high mental stress,going on a diet,irregular menstruation,childbearing history and complicating other diseases had statistical differences between the two groups(P＜0.05).The multivariate logistic regression analysis results showed that the familial inheritance history,often staying up,sleep disorder,like to eat high carbohydrate food,like to eat high fat food,high men-tal stress,going on a diet,irregular menstruation,childbearing history and complicating other diseases were the independent risk factors leading to FAGA(P＜0.05).Conclusion It is necessary to do a good job in the complicating disease screening of young female hair loss groups and pay attention to the related risk factors.

Objective:To investigate the clinical manifestations, serological and cerebrospinal fluid test results for syphilis, imaging features, and prognoses of cerebral syphilitic gumma.Methods:The clinical data of 1 patient with cerebral syphilitic gumma admitted to Department of Neurology, Second Affiliated Hospital of Soochow University in March 2023 were retrospectively analyzed. Papers about cerebral syphilitic gumma were searched from journals in Journal Citation Reports Q1 from 2000 to 2019, journals from 2020 to 2024 in PubMed, WOS, Embase, and Scopus databases, and journals from 2000 to 2024 in Wanfang Database, CNKI, and VIP database; the clinical data of 54 patients with cerebral syphilitic gumma reported in above databases and 1 patient in our hospital were collected for pooled analysis.Results:The main clinical manifestations of 55 cerebral syphilitic gumma patients included headache (32, 58.2%), lateral limb/facial weakness (25, 45.5%), nausea and vomiting (14, 25.5%), dizziness (11, 20.0%), sensory disturbances (10, 18.2%), blurred vision (7, 12.7%), seizure (5, 9.1%)), hearing loss (5, 9.1%), tinnitus (5, 9.1%), memory loss (3, 5.5%), aphasia (3, 5.5%), dysarthria (2, 3.6%), drop attack (2, 3.6%), weakness in opening eyes (2, 3.6%), unresponsiveness (1, 1.8%), Argyll-Robertson pupil (1, 1.8%), tabes dorsalis gait (1, 1.8%), and fever (1, 1.8%). In 51 patients who reported complete serologic test results, 45 patients (88.2%) were positive for non-specific antibodies to syphilis, and all patients were positive for specific antibodies to syphilis. In 34 patients underwent cerebrospinal fluid examination, 25 (73.5%) were positive for non-specific antibodies to syphilis, and 32 (94.1%) were positive for specific antibodies to syphilis. Isolated intracranial lesion (43, 78.2%) was mostly common in imaging test, and the frequently involved cranial sites were, orderly, the frontal lobe (14, 25.5%), parietal lobe (14, 25.5%), temporal lobe (5, 9.1%), frontotemporal lobe (3, 5.5%), frontoparietal lobe (2, 3.6%), parieto-occipital lobe (2, 3.6%), nucleus pulposus (1, 1.8%), clivus (1/55, 1.8%), and cerebral peduncle of the midbrain (1, 1.8%). Thirty patients (54.5%) were misdiagnosed as having other intracranial space-occupied diseases, orderly, glioma (11, 36.7%), metastatic tumors (5, 16.7%), meningiomas (4, 13.3%), other unexplained intracranial space-occupying (4, 13.3%), brain abscess (3, 10.0%), cavernous hemangioma (1, 3.3%), intracranial lymphoma (1, 3.3%), auditory nerve and pituitary tumors (1, 3.3%). Of the 42 patients who reported prognosis after anti-syphilitic treatments, 41 had varying degrees of improvement, and one died of brain herniation.Conclusion:Because of atypical clinical manifestations and lack of clear diagnostic criteria, cerebral syphilitic gumma is often misdiagnosed as intracranial tumors; cerebral syphilitic gumma should be considered in patients with positive non-specific antibodies to syphilis/specific antibodies to syphilis in serum and cerebrospinal fluid having neurological symptoms and intracranial space-occupied foci; timely diagnosed and treated patients can prognosed well.

Migraine, a prevalent neurological disorder, obviously impairs the quality of life of the patients. α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are ion channel glutamate receptors that are responsible for facilitating rapid excitatory nerve signal transmission. Current study has revealed that AMPA receptors play a crucial role in migraine development. This article reviews the structure and function of AMPA receptors, relationship between AMPA receptors and migraine, and its application in migraine treatment, in order to provide new insights for pathogenesis and treatment of migraine.

Migraine, a prevalent neurological disorder, obviously impairs the quality of life of the patients. α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are ion channel glutamate receptors that are responsible for facilitating rapid excitatory nerve signal transmission. Current study has revealed that AMPA receptors play a crucial role in migraine development. This article reviews the structure and function of AMPA receptors, relationship between AMPA receptors and migraine, and its application in migraine treatment, in order to provide new insights for pathogenesis and treatment of migraine.

Objective: To understand the emotion state and emotion trajectory of adolescents during the transition stage from high school to college by analyzing text on social network platform, and to provide reference for carring out mental education for adolescents. Methods: From September to November 2018 and September to October 2019, 534 undergraduates were recruited through online and offline advertisement, and their Tencent Tweets posted during the period from last year of high school to first year of college were crawled and stored with the time stamps. Total number of words, the number of Tencent Tweets, frequency of positive emotion words and negative emotion words were obtained by using jieba (a word segmentation program) and an emotion dictionary. The degree of activity in Tencent Tweets during the transition stage were described. The trend of the frequency of negative and positive emotion words were analyzed by using hierarchical linear model. The degree of activity and trend of monthly variation between high school and colleges were also compared. Results: After entering college, adolescents degree of activity in Tencent Tweets were much higher. Total number of words, number of Tencent Tweets, number of positive emotion words and negative emotion words were significantly higher than those in high school (Wilcoxon Z =-18.93, -18.03, -18.40, -13.60, P <0.01). Total number of words, number of Tencent Tweets, number of positive emotion words and negative emotion words posted by female adolescents were significantly higher than male adolescents during first year of college (Mann-Whitney U =26 499.00, 28 581.00, 24 636.00, 28 010.50 , P <0.05). There were more positive emotion words than negative emotion words in adolescents Tencent Tweets, the monthly average frequency of positive emotion words (0.029) was 2.40 times of frequency of negative emotion words (0.012). The frequency of positive emotion words and negative emotion words decreased significantly with each month in the last year of high school ( β =-6.01, 3.55; t=-3.40, -2.86, P <0.01). Conclusion Adolescents were less active in using Tencent Tweets in last year of high school, but their positive and negative emotional fluctuation were more intense in Tencent Tweets. It is noteworthy to pay attention to the emotional state of adolescents in last year of high school.