1.Digital and intelligent medicine empowering precision abdominal surgery:today and the future
Qian DONG ; Jingmiao WANG ; Wenli XIU
Chinese Journal of Surgery 2025;63(10):878-882
The complex anatomical structure of abdominal organs demands high precision in surgical procedures, which also increases postoperative complication risks. Advancements in digital medicine have created new opportunities for precision surgery. This article summarizes the current applications of digital intelligence in precision abdominal surgery. The processing and real-time monitoring technologies of medical imaging provide powerful tools for accurate diagnosis and treatment. Meanwhile, big data analysis and precise classification capabilities of artificial intelligence further enhance diagnostic efficiency and safety. Additionally, the paper analyzes the advantages and limitations of digital intelligence in empowering precision abdominal surgery, while exploring future development directions.
2.Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China
Changzi WU ; Xiaochen WANG ; Yue CHEN ; Zheng LI ; Yi ZHANG ; Yuan WEI ; Bing WU ; Wenli ZHANG ; Zhengxiong YANG ; Xiaojie DONG ; Ruiting HAO ; Xiu YE ; Luxi WEI ; Yingli QU ; Haiyan CHU ; Yuebin LYU ; Ying ZHU ; Dongqun XU ; Xiaoming SHI
Chinese Journal of Preventive Medicine 2025;59(2):209-215
Objective:To explore the relationship between urinary cadmium levels and thyroid hormone levels in people aged 40-89 years old in selected areas of China.Methods:Based on the "Investigation of the Impact of Soil Quality of Agricultural Land on Human Health in Typical Areas" project from October 2019 to August 2020, a multi-stage stratified random sampling method was used to include 6 588 middle-aged and older adults aged 40-89. Demographic characteristics, dietary frequency and disease status were collected through the questionnaire and physical examination. Urinary cadmium and urinary creatinine were detected by random midstream urine. Fasting venous blood was collected for the detection of Triiodothyronine (T3) and Thyroxine (T4). The linear mixed effects model was used to explore the association of urine cadmium levels with thyroid hormone levels. Its dose-response relationship was explored by using the restricted cubic spline.Results:The age of the subjects was (63.48±12.18) years, with males accounting for 51.28%. The M ( Q 1,Q 3) of urinary cadmium level, T3 and T4 was 2.48 (1.36, 4.42) μg/g·creatinine, (1.96±0.51) nmol/L and (113.75±29.11) nmol/L, respectively. The linear mixed effects model showed that the changes of T3 and T4 were 0.027 (0.009, 0.044) nmol/L and 2.019 (1.084, 2.953) nmol/L for each one-unit increase (natural logarithm transformed) of urinary cadmium. The restricted cubic spline showed that there was a positive nonlinear association between urinary cadmium and T3 as well as T4 (all Pnonlinear<0.05). Conclusion:In selected areas of China, the urinary cadmium level of middle-aged and older adults aged 40-89 years is positively associated with T3 and T4.
3.Analysis of the levels and food source of cadmium exposure by dietary pathway among middle-aged and elderly populations in cadmium-contaminated areas of China
Xiaochen WANG ; Yi ZHANG ; Xiaojie DONG ; Ruiting HAO ; Xiu YE ; Wenli ZHANG ; Ying ZHU ; Ailing LIU ; Yuan WEI ; Bing WU ; Yufei LUO ; Changzi WU ; Yanning MA ; Zhengxiong YANG ; Yuebin LYU ; Gangqiang DING ; Dongqun XU ; Xiaoming SHI
Chinese Journal of Preventive Medicine 2025;59(5):597-603
Objective:To evaluate the levels and source of cadmium exposure by dietary pathway among middle-aged and elderly people ≥40 in cadmium-contaminated areas of China.Methods:A total of 7 193 people aged 40-89 years from four typical cadmium-contaminated areas in China were selected as the study subjects. Food Frequency Questionnaire (FFQ), Total Diet Study (TDS) and a 3-day-24-hour dietary recall survey were conducted. Dietary cadmium intake and food sources through dietary pathways were assessed based on cadmium content in foods, consumption amounts and intake frequencies.Results:The mean age of the participants was 63.39±12.21 years, with 50.05% being males. The average monthly dietary cadmium intake was 7.39 μg/(kg·BW). Staple foods and vegetables were the primary sources of dietary cadmium intake, accounting for 57.51% and 32.48%, respectively. The monthly dietary cadmium intake in all surveyed regions did not exceed the Provisional Tolerable Monthly Intake (PTMI) recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).Conclusion:The monthly dietary cadmium intake among middle-aged and elderly people in cadmium-contaminated areas of China is relatively low, with the risk remaining at an acceptable level. Staple foods and vegetables are the most significant contributors to dietary cadmium intake.
4.Interpretation of the international multidisciplinary consensus recommendations on clinical application of three-dimensional visualization in precision surgery for pediatric liver tumors
Qian DONG ; Wenli XIU ; Jingli ZHANG ; Yoshinori KOYA ; Giulianotti Pier CRISTOFORO
Chinese Journal of Digestive Surgery 2025;24(5):559-566
Pediatric liver tumors are predominantly primary malignant tumors. Due to the delicate anatomical structures of the liver in children, the typically large tumor size, and frequent involvement of major hepatic vessels, surgical intervention poses significant challenges. Complete tumor resection while preserving sufficient remnant functional liver tissue is critical for improving prognosis. With the emergence of precision surgery concepts and advancements in computer tech-nology, three-dimensional visualization technology has gained increasing attention in the diagnosis and treatment of pediatric liver tumors. This technology can enhance surgical accuracy and safety through precise preoperative planning, intraoperative guidance, and postoperative follow-up. To standardize the application of three-dimensional visualization technology in pediatric liver tumor management, professor Dong Qian from The Affiliated Hospital of Qingdao University has collabora-ted with 36 multidisciplinary experts from 8 countries to establish an international expert consensus on the clinical implementation of this technology in precision surgery for pediatric liver tumors. The authors provide an interpretation of the proposed consensus, aiming to guide clinicians in the standardized application of three-dimensional visualization technology during pediatric liver tumor resections.
5.Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China
Changzi WU ; Xiaochen WANG ; Yue CHEN ; Zheng LI ; Yi ZHANG ; Yuan WEI ; Bing WU ; Wenli ZHANG ; Zhengxiong YANG ; Xiaojie DONG ; Ruiting HAO ; Xiu YE ; Luxi WEI ; Yingli QU ; Haiyan CHU ; Yuebin LYU ; Ying ZHU ; Dongqun XU ; Xiaoming SHI
Chinese Journal of Preventive Medicine 2025;59(2):209-215
Objective:To explore the relationship between urinary cadmium levels and thyroid hormone levels in people aged 40-89 years old in selected areas of China.Methods:Based on the "Investigation of the Impact of Soil Quality of Agricultural Land on Human Health in Typical Areas" project from October 2019 to August 2020, a multi-stage stratified random sampling method was used to include 6 588 middle-aged and older adults aged 40-89. Demographic characteristics, dietary frequency and disease status were collected through the questionnaire and physical examination. Urinary cadmium and urinary creatinine were detected by random midstream urine. Fasting venous blood was collected for the detection of Triiodothyronine (T3) and Thyroxine (T4). The linear mixed effects model was used to explore the association of urine cadmium levels with thyroid hormone levels. Its dose-response relationship was explored by using the restricted cubic spline.Results:The age of the subjects was (63.48±12.18) years, with males accounting for 51.28%. The M ( Q 1,Q 3) of urinary cadmium level, T3 and T4 was 2.48 (1.36, 4.42) μg/g·creatinine, (1.96±0.51) nmol/L and (113.75±29.11) nmol/L, respectively. The linear mixed effects model showed that the changes of T3 and T4 were 0.027 (0.009, 0.044) nmol/L and 2.019 (1.084, 2.953) nmol/L for each one-unit increase (natural logarithm transformed) of urinary cadmium. The restricted cubic spline showed that there was a positive nonlinear association between urinary cadmium and T3 as well as T4 (all Pnonlinear<0.05). Conclusion:In selected areas of China, the urinary cadmium level of middle-aged and older adults aged 40-89 years is positively associated with T3 and T4.
6.Analysis of the levels and food source of cadmium exposure by dietary pathway among middle-aged and elderly populations in cadmium-contaminated areas of China
Xiaochen WANG ; Yi ZHANG ; Xiaojie DONG ; Ruiting HAO ; Xiu YE ; Wenli ZHANG ; Ying ZHU ; Ailing LIU ; Yuan WEI ; Bing WU ; Yufei LUO ; Changzi WU ; Yanning MA ; Zhengxiong YANG ; Yuebin LYU ; Gangqiang DING ; Dongqun XU ; Xiaoming SHI
Chinese Journal of Preventive Medicine 2025;59(5):597-603
Objective:To evaluate the levels and source of cadmium exposure by dietary pathway among middle-aged and elderly people ≥40 in cadmium-contaminated areas of China.Methods:A total of 7 193 people aged 40-89 years from four typical cadmium-contaminated areas in China were selected as the study subjects. Food Frequency Questionnaire (FFQ), Total Diet Study (TDS) and a 3-day-24-hour dietary recall survey were conducted. Dietary cadmium intake and food sources through dietary pathways were assessed based on cadmium content in foods, consumption amounts and intake frequencies.Results:The mean age of the participants was 63.39±12.21 years, with 50.05% being males. The average monthly dietary cadmium intake was 7.39 μg/(kg·BW). Staple foods and vegetables were the primary sources of dietary cadmium intake, accounting for 57.51% and 32.48%, respectively. The monthly dietary cadmium intake in all surveyed regions did not exceed the Provisional Tolerable Monthly Intake (PTMI) recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).Conclusion:The monthly dietary cadmium intake among middle-aged and elderly people in cadmium-contaminated areas of China is relatively low, with the risk remaining at an acceptable level. Staple foods and vegetables are the most significant contributors to dietary cadmium intake.
7.Interpretation of the international multidisciplinary consensus recommendations on clinical application of three-dimensional visualization in precision surgery for pediatric liver tumors
Qian DONG ; Wenli XIU ; Jingli ZHANG ; Yoshinori KOYA ; Giulianotti Pier CRISTOFORO
Chinese Journal of Digestive Surgery 2025;24(5):559-566
Pediatric liver tumors are predominantly primary malignant tumors. Due to the delicate anatomical structures of the liver in children, the typically large tumor size, and frequent involvement of major hepatic vessels, surgical intervention poses significant challenges. Complete tumor resection while preserving sufficient remnant functional liver tissue is critical for improving prognosis. With the emergence of precision surgery concepts and advancements in computer tech-nology, three-dimensional visualization technology has gained increasing attention in the diagnosis and treatment of pediatric liver tumors. This technology can enhance surgical accuracy and safety through precise preoperative planning, intraoperative guidance, and postoperative follow-up. To standardize the application of three-dimensional visualization technology in pediatric liver tumor management, professor Dong Qian from The Affiliated Hospital of Qingdao University has collabora-ted with 36 multidisciplinary experts from 8 countries to establish an international expert consensus on the clinical implementation of this technology in precision surgery for pediatric liver tumors. The authors provide an interpretation of the proposed consensus, aiming to guide clinicians in the standardized application of three-dimensional visualization technology during pediatric liver tumor resections.
8.Digital and intelligent medicine empowering precision abdominal surgery:today and the future
Qian DONG ; Jingmiao WANG ; Wenli XIU
Chinese Journal of Surgery 2025;63(10):878-882
The complex anatomical structure of abdominal organs demands high precision in surgical procedures, which also increases postoperative complication risks. Advancements in digital medicine have created new opportunities for precision surgery. This article summarizes the current applications of digital intelligence in precision abdominal surgery. The processing and real-time monitoring technologies of medical imaging provide powerful tools for accurate diagnosis and treatment. Meanwhile, big data analysis and precise classification capabilities of artificial intelligence further enhance diagnostic efficiency and safety. Additionally, the paper analyzes the advantages and limitations of digital intelligence in empowering precision abdominal surgery, while exploring future development directions.
9.Aesthetic reconstruction of distal segment of finger with modified second toe nail flap without sacrifice a toe
Xiaolei XIU ; Hang YU ; Yanhong GAO ; Tong LI ; Ning ZHANG ; Guangxian CHEN ; Chuang LI ; Wenli CHANG ; Hongfei WANG ; Jianyong ZHAO
Chinese Journal of Microsurgery 2022;45(2):148-151
Objective:To explore the method and effect of aesthetic reconstruction of distal segment of finger with modified second toe nail flap while retains the full length of the second toe.Methods:From April 2018 to June 2020, 16 patients with degloving injury of distal segment of fingers were treated. The patients were 11 males and 5 females aged 18 to 45 years in an average of 29 years. All injuries were degloving injury of the distal segment of finger, including 5 index fingers, 7 middle fingers, 3 ring fingers and 1 little finger. The time from injury to operation was 0.5-3.0 hours, with an average of 1.5 hours. The second toe nail flap was used for the reconstruction. After the dorsal flap of the second toe was rotated to the plantar side of the foot, the donor site defect was repaired by a skin graft. The regular follow up reviews were carried out.Results:All 16 flaps survived except 1 flap had necrosis and underwent toe amputation of the distal segment of the second toe. All patients entered follow-up for 4-12 months, with an average of 5.7 months. The blood supply of all flaps was good. After the flaps having atrophied, they were equivalent to the diameter of the body of normal fingers with the TPD at 6.5(4-10) mm; All patients returned to work. According to the Evaluation Standard of Upper Limb Function of Chinese Hand Surgery Society, 13 cases were graded as excellent, 2 were good and 1 was fair.Conclusion:The techniques of modified second toe toenail flap in aesthetic reconstruction of the distal segment of a finger can effectively restore the length and aesthetic appearance of the affected finger, without sacrificing the donor toe. Clinical application of it should be promoted.
10.Repair of finger pulp defect with free second toe pulp flap anastomosed with palmar vein
Xiaolei XIU ; Hang YU ; Wenli CHANG ; Ning ZHANG ; Tong LI ; Xuelei ZHANG ; Guangxian CHEN ; Hongfei WANG ; Jianyong ZHAO
Chinese Journal of Microsurgery 2020;43(3):254-256
Objective:To explore a surgical procedure of reconstruction finger pulp defect with free toes plantar flap with vascular anastomosis of toe-finger artery and plantar-palmar vein of finger.Methods:From April, 2018 to November, 2019, 15 patients with finger pulp defect were repaired by transplantation of the second toe pulp. In the procedure, the plantar vein of the toe and palmar vein of the finger were anastomosed. The artery and nerve of the toe and finger were anastomosed. The flap size was 0.8 cm×0.5 cm-1.0 cm×1.2 cm. The donor site was primary closed without deformity and other complication.Results:All flaps survived without vascular crisis. The mean followed-up period was 5.7 (range 3-9) months. The flaps had good blood flow, soft texture and good elasticity. Three months after surgery, touch sensation was partly recovered in some patients, and while pain was partly recovered in some patients 4-6 months after surgery. There was no deformity and other complication in the donor site. The donor sites of the foot had good appearance and normal walking function.Conclusion:The free toe plantar flap anastomosed with palmar vein can repair the digital pulp defect without dissecting the dorsal vein of digital (toe), and the donor sites can be primary sutured without deformity and other complications. The surgery operation is simple with satisfactory clinical effect.

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