Objective To explore the research status,hotspots and trends in the field of traditional Chinese medicine in the treatment of dysfunctional uterine bleeding(DUB).Methods Relevant literatures on the treatment of DUB with traditional Chinese medicine were retrieved from China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform and VIP.Multi-dimensional visual analysis was conducted on the annual number of published papers,authors and institutions,and keywords using CiteSpace software.Results A total of 1649 literatures were included according to the inclusion and exclusion criteria.The top three authors in terms of the number of published articles are You Zhaoling,Ma Huirong,and Wu Yanan.Shandong University of Traditional Chinese Medicine is the institution that has published the most papers.The research on the treatment of DUB with traditional Chinese medicine mainly focuses on the integrated treatment of traditional Chinese and Western medicine,perimenopause,adolescence,therapeutic effect observation,Guchong decoction,sex hormones,and so on.Conclusion The research on the treatment of DUB with traditional Chinese medicine mainly focuses on the application of traditional Chinese medicine prescriptions,clinical observation and therapeutic effect indicators,etc.Subsequently,in-depth exploration of new traditional Chinese medical therapies and new observation indicators is still needed.In the future,the observation of new microscopic indicators and the research on pathological mechanisms may be potential research hotspots and directions.

Objective To explore the research status,hotspots and trends in the field of traditional Chinese medicine in the treatment of dysfunctional uterine bleeding(DUB).Methods Relevant literatures on the treatment of DUB with traditional Chinese medicine were retrieved from China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform and VIP.Multi-dimensional visual analysis was conducted on the annual number of published papers,authors and institutions,and keywords using CiteSpace software.Results A total of 1649 literatures were included according to the inclusion and exclusion criteria.The top three authors in terms of the number of published articles are You Zhaoling,Ma Huirong,and Wu Yanan.Shandong University of Traditional Chinese Medicine is the institution that has published the most papers.The research on the treatment of DUB with traditional Chinese medicine mainly focuses on the integrated treatment of traditional Chinese and Western medicine,perimenopause,adolescence,therapeutic effect observation,Guchong decoction,sex hormones,and so on.Conclusion The research on the treatment of DUB with traditional Chinese medicine mainly focuses on the application of traditional Chinese medicine prescriptions,clinical observation and therapeutic effect indicators,etc.Subsequently,in-depth exploration of new traditional Chinese medical therapies and new observation indicators is still needed.In the future,the observation of new microscopic indicators and the research on pathological mechanisms may be potential research hotspots and directions.

Premature ovarian insufficiency(POI),also known as"ovarian insufficiency",has an incidence of 1％～5％.The incidence has been on the rise in recent years,seriously affecting women's physical and mental health and quality of life.At present,the cause and mechanisms of POI are still unclear,and the method and applications of model construction are also confusing.Most models have some shortcomings in pertinence and stability.The limitations greatly limit research into the clinical diagnosis and treatment of POI.This paper summarizes and discusses the etiology and pathogenesis of POI and the construction of POI animal models to provide a comprehensive reference for those studying POI.

Objective:To investigate the status of satisfaction of postgraduates majoring in public health with the teaching material of The prevention and control of chronic non- communicable disease, so as to provide the basis for promoting the teaching and optimizing the reprint of the teaching material. Methods:An online survey was conducted among 180 public health postgraduates of Batch 2018 to Batch 2020 from China CDC who took the selective course of "prevention and control of chronic non-communicable diseases". The survey content included the overall satisfaction of the respondents with the teaching material and such four levels of satisfaction as primary indicators at the content level, thinking level, motivation level and arrangement level and 20 secondary indicators. The statistical analysis was made by SPSS 25.0.Results:The effective response rate was 90.56% (163/180), and the overall satisfaction of postgraduates with the teaching material was 88.96%. The satisfaction of "scientificity", "comprehensiveness", "internal coordination" and "hierarchy" at the content level, "systematic thinking" and "quality education" at the thinking level, "deepening the understanding and application of relevant knowledge in the field of chronic disease prevention and control" and "the content is convenient for self-study and helps guide the construction of new knowledge" at the motivation level, and "accurate words, fluent language and easy to read and understand" and "firm binding, good paper quality and clear printing" at the arrangement level of the teaching material was more than 90.00%. Only the satisfaction of "the critical thinking" at the thinking level and "stimulating learning enthusiasm" at the motivation level was less than 85.00%.Conclusion:The teaching material of The prevention and control of chronic non- communicable disease meets the learning needs of postgraduates majoring in public health, and students have high overall satisfaction evaluation on the teaching material. It is necessary to further optimize the two aspects of "the critical thinking" and "stimulating learning enthusiasm" in the revision of the teaching material.

Objective:To evaluate the efficacy of Baduanjin combined with mecobalamin tablets in the treatment of type 2 diabetic peripheral neuropathy. Methods:Eighty patients with type 2 diabetic peripheral neuropathy who met the inclusion criteria were randomly divided into two groups with 40 patients in each group ( n=40). The control group took oral mecobalamin tablets and self-management, and the treatment group were treated with Baduanjin on the basis of the control group. All patients were treated for 12 weeks. The clinical symptoms were evaluated by Toronto Clinical Scoring System (TCSS), and the motor nerve conduction velocity (MCV) of tibial nerve and the sensory conduction velocity (SCV) of superficial peroneal nerve were measured by EMG evoked potential instrument. The hemorheological indexes (whole blood low shear viscosity, whole blood high shear viscosity and plasma viscosity) were measured before and after treatment. The clinical efficacy was evaluated and adverse events were recorded. Results:In the course of treatment, 39 patients in each group completed the study with each one dropout. The total effective rate was 87.2% (34/39) in the treatment group and 64.1% (25/39) in the control group. There was significant difference between the two groups ( χ2=5.64, P=0.018). After treatment, the TCSS score of the treatment group was significantly lower than that of the control group ( t=-6.23, P<0.01), the tibial nerve MCV (43.06 ± 4.19 m/s vs. 39.55 ± 4.30 m/s, t=3.65), the superficial peroneal nerve SCV (43.23 ± 4.31 m/s vs. 39.92 ± 3.74 m/s, t=3.62) in the treatment group were significantly higher than the control group ( P<0.001), while the whole blood high shear viscosity, the whole blood low shear viscosity, and the plasma viscosity in the treatment group were significantly lower than the control group ( t value were -10.36, -14.21, -13.88, all Ps<0.001). During the treatment, no serious adverse events occurred in both groups. Conclusion:Baduanjin combined with mecobalamin tablets in the treatment of type 2 diabetic peripheral neuropathy can reduce blood viscosity, promote blood circulation, increase nerve conduction velocity, improve clinical symptoms and signs, and improve clinical efficacy.

OBJECTIVETo assess the clinical value of (18)F-FDGPET/CT in the diagnosis of larynx carcinoma. Methods Forty-seven patients with larynx carcinoma or suspected larynx carcinoma underwent (18)F-FDG PET/CT examination within a week before therapy. The value of (18)F-FDG PET/CT in the diagnosis and staging of the malignancy was compared with that of unenhanced contrast CT.

METHODSForty-seven patients with larynx carcinoma or suspected larynx carcinoma underwent (18)F-FDG PET/CT examination within a week before therapy. The value of (18)F-FDG PET/CT in the diagnosis and staging of the malignancy was compared with that of unenhanced contrast CT.

RESULTSAmong the 47 patients, a definite diagnosis of larynx carcinomas was established pathologically in 43 patients. For detection of primary tumors, the sensitivity, specificity and accuracy of (18)F-FDG PET/CT were 95.3%, 75% and 93.6%, as compared with 74.4%, 50%, and 72.3% with unenhanced contrast CT scan, respectively, showing significant differences in the diagnostic sensitivity and accuracy between the two modalities (Χ=7.340, P=0.007; Χ=7.532, P=0.006). Twenty-six of the 43 patients were identified to have lymph node metastasis, for which (18)F-FDG PET/CT showed a significantly higher diagnostic sensitivity than unenhanced contrast CT (92.3% vs 61.5%, Χ=6.933, P=0.008). In the 46 excised lymph nodes from 19 patients, 26 were found positive for metastasis, for which (18)F-FDG PET/CT showed a diagnostic sensitivity of 92%, significant higher than that with unenhanced contrast CT (64%, Χ=5.71, P=0.017). PET/CT detected synchronous tumor in one case. (18)F-FDG PET/CT resulted in a change of staging in 34.9% of the patients, including upstaging in 14 patients and down-staging in one patient.

CONCLUSION(18)F-FDG PET/CT can be an important means for diagnosis and initial staging of larynx carcinoma.

Adult ; Aged ; Carcinoma ; diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Laryngeal Neoplasms ; diagnostic imaging ; Middle Aged ; Multimodal Imaging ; methods ; Positron-Emission Tomography ; Tomography, X-Ray Computed