Objective To observe the clinical efficacy of Ginkgo Diterpene Lactone Meglumine Injection combined with alteplase(rt-PA)in the treatment of acute ischemic stroke with large vessel occlusion.Methods A total of 170 patients with acute ischemic stroke with large vessel occlusion were selected as the study subjects and randomly divided into control group(receiving intravenous rt-PA thrombolytic therapy)and observation group(receiving Ginkgo Diterpene Lactone Meglumine In-jection in addition to the treatment in the control group),with 85 cases in each group.Serological in-dicators[neuron-specific enolase(NSE),vascular endothelial growth factor(VEGF),homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP),matrix metalloproteinase-9(MMP-9)],cere-bral blood flow velocity in the middle cerebral artery[end-diastolic velocity(EDV),peak systolic ve-locity(PSV),mean velocity(Vm)],neurological function[National Institutes of Health Stroke Scale(NIHSS)score],cognitive function[Mini-mental State Examination(MMSE)score],modi-fied Rankin Scale(mRS)score,and the incidence of complications were compared between the two groups.Results After treatment,the serum levels of NSE,Hcy,hs-CRP,MMP-9,and the NIHSS and mRS scores in both groups were lower than those before treatment,while the serum level of VEGF and the MMSE score were higher than those before treatment(P＜0.05).Moreover,the serum lev-els of NSE,Hcy,hs-CRP,MMP-9,and the NIHSS and mRS scores in the observation group were lower than those in the control group,and the serum level of VEGF and the MMSE score were higher than those in the control group,with statistically significant differences(P＜0.05).After treat-ment,the EDV,PSV and Vm in both groups were higher than those before treatment,and those in the observation group were higher than those in the control group,with statistically significant differ-ences(P＜0.05).There was no statistically significant difference in the overall incidence of com-plications between the two groups(P＞0.05).Conclusion Ginkgo Diterpene Lactone Meglumine Injection combined with rt-PA can effectively improve the neurological and cognitive functions of a-cute ischemic stroke patients with large vessel occlusion.

Both periodontitis and diabetes are chronic inflammatory diseases, which are widely prevalent in the world. For more than 50 years, the research on the relationship between periodontitis and type 2 diabetes has been actively carried out. The epidemiological correlation between these diseases has been basically identified, but the impact of periodontal therapy on glycaemic control in patients with type 2 diabetes has been controversial for a long time. Glycaemic control is a key issue in the care of people with diabetes. If the positive effect of periodontal therapy on improving glycemic control in diabetic patients compared with no active treatment can be identified, it will help establish periodontal therapy as an effective auxiliary measure for glycaemic control of diabetes patients, and further confirm the relationship between dental health and systemic diseases. Through reviewing the literature, it has been basically determined that the glycaemic control of diabetes patients can be improved within 6 months after the commencement of non-surgical periodontal therapy. In addition, the guidelines of diabetes and suggestions involved periodontal therapy that are constantly put forward by various countries and health organizations at all levels,while in China with extremely heavy in the burden of diabetes, also should propose the guidelines and suggestions of diabetes in accordance with China′s national conditions. Both periodontitis and diabetes are diseases with special emphasis on prevention. To clarify the relationship between periodontitis and diabetes can give enlightenment in preventing the occurrence and development of the two diseases.

Both periodontitis and diabetes are chronic inflammatory diseases, which are widely prevalent in the world. For more than 50 years, the research on the relationship between periodontitis and type 2 diabetes has been actively carried out. The epidemiological correlation between these diseases has been basically identified, but the impact of periodontal therapy on glycaemic control in patients with type 2 diabetes has been controversial for a long time. Glycaemic control is a key issue in the care of people with diabetes. If the positive effect of periodontal therapy on improving glycemic control in diabetic patients compared with no active treatment can be identified, it will help establish periodontal therapy as an effective auxiliary measure for glycaemic control of diabetes patients, and further confirm the relationship between dental health and systemic diseases. Through reviewing the literature, it has been basically determined that the glycaemic control of diabetes patients can be improved within 6 months after the commencement of non-surgical periodontal therapy. In addition, the guidelines of diabetes and suggestions involved periodontal therapy that are constantly put forward by various countries and health organizations at all levels,while in China with extremely heavy in the burden of diabetes, also should propose the guidelines and suggestions of diabetes in accordance with China′s national conditions. Both periodontitis and diabetes are diseases with special emphasis on prevention. To clarify the relationship between periodontitis and diabetes can give enlightenment in preventing the occurrence and development of the two diseases.

Objective To study the value of postmortem imaging on the diagnosis of intestinal perforation.Method Postmortem imaging(PMCT and PMCTA)data of 2 intestinal perforation deaths(and 4 controlled cases)were reviewed retrospectively.Diagnosing capacities of intestinal perforation by postmortem imaging method were further investigated.Results PMCT is sensitive in detecting the free air and liquid induced by intestinal perforation.PMCT can sometimes detect the gravity-dependent purulent secretions in the abdominopelvic cavity.PMCTA can visualize the extravasation of contrast agent from the perforation,which can be used to locate the accurate perforation region.Conclusion Postmortem imaging method(PMCT and PMCTA)is an important tool for the diagnosis of intestinal perforation,which can not only be used as a forensic diagnosis method,but is also useful to locate the perforation site before an forensic autopsy.

We have studied the inhibitory effect of polysaccharides mixture on Ehrlich Ascites Carcinoma (EAC), Sarcoma 180 (S180), reticulocytic leukemia (L615) in mice. It is found that polysaccharides mixture could obviously prolong the survival duration of mice suffering from tumour and inhibit neoplastic proliferation. Thymus and adrenal glands atrophy in mice caused by vaccination of cancer cells was also remarkably resisted.The results of our experiments show that polysaccharides mixture is a safe,effective and promising pharmaceutic preparation of traditional Chinese medicine. It deserves to be further studied and developed.