【Objective:】 To study the emotional experience of family caregivers of patients with Pemphigus, and to provide reference for them to formulate targeted intervention and support. 【Methods:】 Using the phenomenological research method in qualitative research and purposive sampling method, in-depth semi-structured interviews were conducted with 13 family caregivers of patients with pemphigus from September 2021 to June 2022. Colaizzi analysis method was used for data analysis. 【Results:】 The emotional experience of family caregivers of inpatients with pemphigus was summarized into five themes: lack of cognition, high financial and psychological burden, more concerns about the use of hormone drugs in treatment, provide positive guidance and support for patients, negative effect on the quality of life. 【Conclusion:】 Nursing staff should pay attention to the emotional experience of family caregivers, enhance disease knowledge and medication explanation, conduct psychological counseling, and increase treatment confidence, so as to achieve the purpose of promoting the rehabilitation of patients.