Objective:To compare the efficacy differences between the combination therapy of Callicarpa nudiflora and dexamethasone versus dexamethasone monotherapy via retention enema in the treatment of acute radiation proctitis.Methods:A total of 100 patients with pelvic malignancies who developed acute radiation proctitis during radiotherapy at Jiangxi Provincial People's Hospital from November 2021 to June 2023 were enrolled,and randomly divided into two groups:a control group(50 cases)vs a treatment group(50 cases).Based on the acute radiation injury scoring criteria established by the Radiation Therapy Oncology Group(RTOG),patients with injury severity scores≤1 were excluded.Subsequently,the remaining patients received the following interventions:the control group(45 cases)underwent single-agent dexamethasone retention enema,while the treatment group(47 cases)received a combined regimen of Callicarpa nudiflora combined with dexamethasone retention enema.Clinical symptoms,defecation frequency,and routine fecal parameters(leukocyte and erythrocyte counts)were recorded before and at 2 weeks of retention enema,to compare the efficacy differences between the two regimens.Results:A statistically significant difference in therapeutic efficacy was observed between the treatment and control groups(χ2=11.37,P=0.003,P<0.05),with the regimen of Callicarpa nudiflora combined with dexamethasone retention enema in the treatment group demonstrating a markedly higher efficacy rate compared to the regimen of single-agent dexamethasone retention enema in the control group(82.2%vs 62.2%).Conclusion:Callicarpa nudiflora combined with dexamethasone retention enema in the treatment of acute radiation proctitis,can significantly alleviates clinical symptoms and improves life quality of patients with acute radiation proctitis.This approach provides novel insights for optimizing clinical treatment strategies for acute radiation proctitis.

Preeclampsia(PE)is a severe pregnancy complication that poses significant risks to maternal and fetal health,and its pathogenesis remains unclear.Recent studies have shown that lactate dehydrogenase(LDH),a key enzyme in glycolysis,plays a piv-otal role in the development and progression of PE.This article reviews the abnormal changes in the levels of LDH and its isozymes in serum and placental tissue and their impact on the pathogenesis of PE and analyzes the molecular mechanisms by which LDH subunits contribute to placental dysfunction through multiple pathways including hypoxia,inflammation,autophagy dysregulation,and cellular damage.In addition,this article discusses the role of lactate,a metabolic product of LDH activity,in the pathogenesis of PE.LDH can be used as a potential biomarker for PE,and the regulation of non-metabolic functions and metabolic reprogramming mediated by LDH provide new targets for the prevention and treatment of PE.

Objective:Taking 88 counties in Guizhou from 2021 to 2023 as the research sample,the indicator system of the dimension of Traditional Chinese Medicine(TCM)are constructed to analyze the spatial evolution and spatial effects of the allocation of TCM human resources in Guizhou.Methods:Using spatial correlation model and Vector Autoregression(VAR)model are applied to conduct the spatial autocorrelation test and impulse response study on the scale,quality and overall configuration of TCM human resources in Guizhou.Results:The allocation levels of TCM human resources in the northern,western and southwestern Guizhou are higher than the southern and southeast Guizhou.There is autocorrelation in the quality level and overall allocation of TCM human resources.The northern Guizhou shows a high-high agglomeration pattern.The scale and quality of TCM human resources are self-driven,while the quality of TCM human resources has a facilitating effect on the scale of human resources,and this facilitating effect gradually increases over time.Conclusion:It is needed to attach great importance to the improvement of TCM human resource quality;implement the policy of differentiated talent development;and give full play to the diffusion and radiation effect of TCM human resource quality and overall allocation in northern Guizhou.

New quality productivity is a strategic engine for promoting high-quality development and is an inherent requirement and important focus for enhancing new driving forces and building national advantages.The cultivation of innovative talents and technological innovation are key to the development of new quality productivity.Laboratory animal science is a comprehensive interdisciplinary subject that integrates multiple disciplines including biology,medicine,pharmacy,and biomedical engineering.Teaching and research of laboratory animal science not only promotes the creation of innovative talent teams by cultivating innovative consciousness,thinking,spirit,and operational abilities,but also promotes the development of cutting-edge technologies and the transformation of disruptive research result in the fields of basic research and clinical translation of biomedicine,thus providing important guarantees for China's scientific and technological progress and innovative development.

Objective:Taking 88 counties in Guizhou from 2021 to 2023 as the research sample,the indicator system of the dimension of Traditional Chinese Medicine(TCM)are constructed to analyze the spatial evolution and spatial effects of the allocation of TCM human resources in Guizhou.Methods:Using spatial correlation model and Vector Autoregression(VAR)model are applied to conduct the spatial autocorrelation test and impulse response study on the scale,quality and overall configuration of TCM human resources in Guizhou.Results:The allocation levels of TCM human resources in the northern,western and southwestern Guizhou are higher than the southern and southeast Guizhou.There is autocorrelation in the quality level and overall allocation of TCM human resources.The northern Guizhou shows a high-high agglomeration pattern.The scale and quality of TCM human resources are self-driven,while the quality of TCM human resources has a facilitating effect on the scale of human resources,and this facilitating effect gradually increases over time.Conclusion:It is needed to attach great importance to the improvement of TCM human resource quality;implement the policy of differentiated talent development;and give full play to the diffusion and radiation effect of TCM human resource quality and overall allocation in northern Guizhou.

Objective:To compare the efficacy differences between the combination therapy of Callicarpa nudiflora and dexamethasone versus dexamethasone monotherapy via retention enema in the treatment of acute radiation proctitis.Methods:A total of 100 patients with pelvic malignancies who developed acute radiation proctitis during radiotherapy at Jiangxi Provincial People's Hospital from November 2021 to June 2023 were enrolled,and randomly divided into two groups:a control group(50 cases)vs a treatment group(50 cases).Based on the acute radiation injury scoring criteria established by the Radiation Therapy Oncology Group(RTOG),patients with injury severity scores≤1 were excluded.Subsequently,the remaining patients received the following interventions:the control group(45 cases)underwent single-agent dexamethasone retention enema,while the treatment group(47 cases)received a combined regimen of Callicarpa nudiflora combined with dexamethasone retention enema.Clinical symptoms,defecation frequency,and routine fecal parameters(leukocyte and erythrocyte counts)were recorded before and at 2 weeks of retention enema,to compare the efficacy differences between the two regimens.Results:A statistically significant difference in therapeutic efficacy was observed between the treatment and control groups(χ2=11.37,P=0.003,P<0.05),with the regimen of Callicarpa nudiflora combined with dexamethasone retention enema in the treatment group demonstrating a markedly higher efficacy rate compared to the regimen of single-agent dexamethasone retention enema in the control group(82.2%vs 62.2%).Conclusion:Callicarpa nudiflora combined with dexamethasone retention enema in the treatment of acute radiation proctitis,can significantly alleviates clinical symptoms and improves life quality of patients with acute radiation proctitis.This approach provides novel insights for optimizing clinical treatment strategies for acute radiation proctitis.

New quality productivity is a strategic engine for promoting high-quality development and is an inherent requirement and important focus for enhancing new driving forces and building national advantages.The cultivation of innovative talents and technological innovation are key to the development of new quality productivity.Laboratory animal science is a comprehensive interdisciplinary subject that integrates multiple disciplines including biology,medicine,pharmacy,and biomedical engineering.Teaching and research of laboratory animal science not only promotes the creation of innovative talent teams by cultivating innovative consciousness,thinking,spirit,and operational abilities,but also promotes the development of cutting-edge technologies and the transformation of disruptive research result in the fields of basic research and clinical translation of biomedicine,thus providing important guarantees for China's scientific and technological progress and innovative development.

Hepatic stellate cell(HSC)activation is a key link in the development of liver fibrosis.The metabolic reprogramming of activated HSC has become a hot topic in current research,especially the change of glycolysis is an important factor in regulating HSC activation.Based on the metabolic reprogramming in the process of HSC activation,this paper expounds the mechanism of regulating HSC activation and liver fibrosis through glycolysis,and reviews the research progress of traditional Chinese medicine and its active ingredients in regulating HSC glycolysis to prevent and treat liver fibrosis.Liver fibrosis is a complex pathological process involving multiple factors and pathways.From the perspective of regulating the glycolysis of activated HSC,it can provide a new idea for the development of anti-liver fibrosis drugs.

Objective To investigate the inhibitory effect and elucidate the molecular mechanism of 6-gingerol on human multiple myeloma cells.Methods The human multiple myeloma cell lines RPMI 8226 and ARH77 were cultured in vitro,followed by treatment with varying concentrations(50,100,200,300,400 μmol/L)of 6-gingerol.The inhibitory effect on cell proliferation was assessed using the CCK-8 assay.Flow cytometry was employed to evaluate cell apoptosis and cycle distribution.Additionally,qRT-PCR and Western blotting techniques were utilized to analyze gene and protein expression levels.Results The proliferation of RPMI 8226 and ARH77 cells was dose-and time-dependently inhibited by 6-gingerol,leading to the induction of apoptosis with statistically significant differences(P＜0.05).Further mechanistic investigations revealed that treatment with 6-gingerol arrested RPMI 8226 cells in the G0/G1 phase,resulting in a significant increase in Bax levels and a decrease in Bcl-2 mRNA and c-Myc mRNA levels(P＜0.05).Additionally,it significantly upregulated the expression of Bax,Cleaved-PARP,Cleaved-caspase3,P53,and p-AKT proteins while down regulating the expression of Bcl-2 protein(P＜0.05).Conclusions The compound 6-Gingerol exhibits inhibitory effects on the proliferation and induction of apoptosis in MM cells,as well as cell cycle arrest at the G0/G1 phase.Its mechanism of action is likely associated with the suppression of the AKT signaling pathway,downregulation of Bcl-2 family protein expression,and inhibition of c-Myc expression.

Environment control and life support(ECLS)system is important to living and working of the astronauts in space station.Made mission reliability assessment for ECLS system of China space station before its launch and after three years operation.In the first place,a reliability model was made in unit's reliability contribution principle.Then multiple data resources was used to evaluate component reliability based on Bayes and Weibull model and evaluate system reliability based on CMSR method.The three year mission reliability assessment made a better understanding for ECLS system reliability of China space station with the flight data accumulation and evaluate subsamples increase since flight mission details has been planned.It showed that the on-orbit non-replaceable units of ECLS system has a longer life and higher inherent reliability.Combined the assessment results with the lifetime extension and reliability demands of the on-orbit replaceable units,the weakness and the trend of change of the system life and reliability was discovered.It can provided a more accurate reference for repair maintence arrangement,on-orbit spare parts planning and supplies launching for ECLS system of China space station.The results can support mission reliability of ECLS system of China space station with on-orbit maintenance and replacement and reliability growth of the units of the system in the future.The reliability modeling and date collection methods of similar units can build a more reasonable reliability model and extend data resource for evaluation.