The coinfection of respiratory viruses and bacteria is a major cause of morbidity and mortality worldwide, despite the development of vaccines and powerful antibiotics. As a macromolecule that is difficult to absorb in the gastrointestinal tract, a homogeneous polysaccharide from Houttuynia cordata (HCPM) has been reported to exhibit anti-complement properties and alleviate influenza A virus (H1N1)-induced lung injury; however, the effects of HCPM without in vitro antiviral and antibacterial activities on more complicated pulmonary diseases resulting from viral-bacterial coinfection remains unclear. This study established a representative coinfection murine pneumonia model infected with H1N1 (0.2 LD₅₀) and methicillin-resistant Staphylococcus aureus (MRSA, 10⁷ CFU). HCPM significantly improved survival rate and weight loss, and ameliorated gut-lung damage and inflammatory cytokine production. Interestingly, the therapeutic effect of HCPM on intestinal damage preceded that in the lungs. Mechanistically, HCPM inhibited the overactivation of the intestinal complement (C3a and C5a) and suppressed the activation of the NLR family pyrin domain-containing 3 (NLRP3) pathway, which contributes to the regulation of the Treg/Th17 cell balance in the gut-lung axis. The results indicate the beneficial effects of an anti-complement polysaccharide against viral-bacterial coinfection pneumonia by modulating crosstalk between multiple immune regulatory networks.

Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as vertical root fracture, primary endodontic diseases, and periodontal diseases, as well as the low awareness of cemental tear for clinicians, misdiagnosis often occurs. The critical principle for cemental tear treatment is to remove torn fragments, and overlooking fragments leads to futile therapy, which could deteriorate the conditions of the affected teeth. Therefore, accurate diagnosis and subsequent appropriate interventions are vital for managing cemental tear. Novel diagnostic tools, including cone-beam computed tomography (CBCT), microscopes, and enamel matrix derivatives, have improved early detection and management, enhancing tooth retention. The implementation of standardized diagnostic criteria and treatment protocols, combined with improved clinical awareness among dental professionals, serves to mitigate risks of diagnostic errors and suboptimal therapeutic interventions. This expert consensus reviewed the epidemiology, pathogenesis, potential predisposing factors, clinical manifestations, diagnosis, differential diagnosis, treatment, and prognosis of cemental tear, aiming to provide a clinical guideline and facilitate clinicians to have a better understanding of cemental tear.
Humans ; Dental Cementum/injuries* ; Consensus ; Diagnosis, Differential ; Cone-Beam Computed Tomography ; Tooth Fractures/therapy*

Prone position ventilation (PPV) is an important protective strategy for lung ventilation, widely used in clinical practice, especially since the novel coronavirus infection pandemic. Since PPV is a non-physiological position, improper implementation and management can lead to serious adverse events such as pressure injury, facial edema, unplanned extubation and (or) reintubation, and even asphyxia. At present, preventive and protective strategies are mainly used to manage PPV-related complications in clinical practice. These strategies not only increase the workload of medical staff and the use of consumables, but also increase the medical cost of patients, further burdening patients and their families economically. To overcome the above problems, the medical staff of the department of critical care medicine of Tianjin Third Central Hospital designed a prone position head auxiliary support device and obtained a national utility model patent (patent number: ZL 2022 2 1751906.3). The device consists of annular plate, folding plate, support frame, reflector and wheel bodies. It serves to reduce pressure on the head and facial skin, while also exposing the mouth, nose, eyes, and ears to the hollow position of the annular plate according to the patient's position. At the same time, the patient's face or side skin can be observed through the lower reflector. The height of the annular plate was adjusted by adjusting the support frame, and the head was raised to reduce facial edema. The setting of strip groove, through hole and hook can sort out the facial pipeline, keep the drainage unobstructed, prevent catheter displacement and unplanned extubation, and has certain clinical promotion and practical value.
Humans ; Prone Position ; Equipment Design ; Respiration, Artificial/methods* ; COVID-19 ; Head ; Patient Positioning

Objective : To explore the microbial contamination status of household washing machines and evaluate the improvement effect of professional washing machine cleaning on microbial contamination. Results : After washing , the total number of fungi in the washing machine ranged from 0 to 49. 22 CFU/cm2 . The fungal clearance rates of the outer wall of the inner cylinder, filter screen , sealring , washing water and detergent drawer box were 99. 36% , 99. 74% , 99. 76% , 99. 51% and 99. 64% , respecing , the number of coliform bacteria was close to 0. Before washing , the average detection rate of Salmonella in the washing machine was 5. 33% , the average detection rate of Shigella was 2. 67% , and no Candida albicans was detected. After washing, Salmonella , Shigella and Candida albicans were not detected. After washing , the total number of fungi in the washing machine ranged from 0 to 49. 22 CFU/cm2 . The fungal clearance rates of the outer wall of the inner cylinder, filter screen , sealring , washing water and detergent drawer box were 99. 36% , 99. 74% , 99. 76% , 99. 51% and 99. 64% , respecing , the number of coliform bacteria was close to 0. Before washing , the average detection rate of Salmonella in the washing machine was 5. 33% , the average detection rate of Shigella was 2. 67% , and no Candida albicans was detected. After washing, Salmonella , Shigella and Candida albicans were not detected. Conclusion There are a large number of bacteria and fungi in the household washing machine before cleaning , and there are Salmonella and Shigella contamination. After professional cleaning , the hygiene condition of the washing machine is significantly improved.

Objective:To deeply understand the pain perception and experience of patients after mixed hemorrhoid surgery, so as to provide reference for taking targeted intervention measures to relieve pain symptoms.Methods:Purpose sampling method was used to conduct semi-structured in-depth interviews with 9 patients with postoperative pain of mixed hemorrhoids admitted to Guilin Hospital of Integrated Traditional Chinese and Western Medicine from February to March 2021, and Colaizzi phenomenological analysis method was used to analyze data and refine themes.Results:The pain perception and experience of patients after mixed hemorrhoid surgery can be summarized into 5 themes: fear of pain, persistent negative thinking about pain, perception of inability to cope with pain, emotional expectation, and expectation of Traditional Chinese Medicine nursing techniques.Conclusions:Patients after mixed hemorrhoid surgery have many burdens and needs in terms of pain experience. Medical staff must establish a complete pain management system for patients after mixed hemorrhoid surgery, aiming at the catastrophic pain experience of patients, correcting their cognitive level of pain management, and satisfying patients Alleviate the need for pain, establish an effective emotional and family support system, improve its pain self-management ability, and promote postoperative recovery.

Objective:To investigate the current situation of early postoperative pain beliefs in patients with mixed hemorrhoids and its influencing factors, and to provide a basis for formulating targeted intervention measures.Methods:Totally 242 postoperative patients with mixed hemorrhoids who were treated in Guilin Integrated Traditional Chinese and Western Medicine were selected by convenience sampling method from January 2020 to January 2021 as the research object. The general information questionnaire, Pain Belief and Perception Scale, Visual Analogue Scale, Positive and Negative Emotion Scale were used to investigate. Multiple linear regression was used to analyze the factors influencing of early postoperative pain beliefs in patients with mixed hemorrhoids.Results:The total score of early postoperative pain belief in patients with mixed hemorrhoids was -21-30 (5.32 ± 2.57) points; the results of multiple linear regression analysis showed that age, education level, anal visual analogue score, and negative emotion scores were main factors affecting their pain beliefs ( r=0.736, P<0.05). Conclusions:Patients with mixed hemorrhoids have negative pain beliefs in the early postoperative period. Patients with advanced age, primary/junior high school, high anal pain intensity, and high negative emotion scores are more likely to have negative pain beliefs. Nursing staff should promptly formulate targeted intervention measures according to the main influencing factors in order to reduce the occurrence of negative beliefs about pain.

Objective:To explore the clinical effect of multidisciplinary cooperative intervention in improving self-management and improving fluid retention in the elderly patients with chronic heart failure.Methods:Totally 130 cases of the elderly patients with chronic heart failure from January to December 2018 were enrolled and were divided into control group and observation group with 65 cases randomly. The control group received routine nursing instruction and telephone follow-up. The observation group was given multidisciplinary team guidance to patients self-management in addition to routine nursing instruction and telephone follow-up. After 3 months, the self-management and fluid retention of the two groups were compared.Results:After 3 months of intervention, the scores and total scores of the observation group in the four dimensions of drug management, diet management, psychological and social adaptation management, symptom management were 19.43±0.71,11.51±0.59,19.07±0.65,25.24±1.31, 72.65±7.16, the control group was 11.09±3.40, 6.05±1.71, 12.73±2.49, 15.72±4.18, 46.35±7.83. The scores and total scores of the observation group were better than those of the control group ( t value was 4.835-13.727, all P < 0.05).After intervention for 3 months, the proportion of severe edema, moderate edema and mild edema in the observation group was 4.61% (3/65), 13.85% (9/65), 81.54% (53/65), respectively, and the control group was 38.46% (25/65), 52.31% (34/65) and 9.23% (6/65) respectively. The degree of fluid retention in the observation group was better than that in the control group ( Z value was -2.373, all P < 0.05). Conclusion:Multidisciplinary cooperative intervention can improve self-management and improve fluid retention in elderly patients with chronic heart failure.

Objective:To understand the cognitive and positive coping strategies of postoperative chemotherapy patients with nausea and vomiting, and to provide a basis for clinical nurses to develop targeted intervention programs.Methods:From May to July 2019, 15 patients with postoperative adjuvant chemotherapy breast cancer who were hospitalized for breast surgery were selected by the purpose sampling method. The phenomenological research method in qualitative research was used to interview them. The Colaizzi data analysis principle was used to analyze the data and refine the theme.Results:Four themes were extracted through analysis: the perception of nausea and vomiting; the accompanying symptoms of nausea and vomiting; nausea and vomiting have different effects on patients' emotions and social interactions; patients adopt various ways to actively deal with nausea and vomiting, including self-regulation, behavioral adjustment, social support, and seeking professional help.Conclusions:Medical staff should pay attention to the nausea and vomiting of patients undergoing postoperative chemotherapy for breast cancer and the coping strategies adopted, and timely evaluate and intervene to alleviate the symptoms and improve their quality of life.

Objective:To understand the driving factors of postpartum health promotion behaviors in pregnant women with gestational diabetes.Methods:From September to October 2019, the purpose of the sampling method was to select 14 cases of gestational diabetic gynaecologists who visited the outpatient department of diabetes care in our hospital as the research subjects. The phenomenological research method was used to conduct a semi-structured interview. Colaizzi′s 7-step analysis method was used to organize and analyze the data to refine the subject.Results:The driving force of postpartum health promotion behaviors of gestational diabetes mothers mainly came from the internal driving force and the external driving force. The internal driving force was mainly the uncertainty of gestational diabetes, the solution of the problem improves self-worth, and the post-traumatic growth made patients re-understand life. The external driving force was mainly family support, full mobilization of subjective initiative, quantitative diet intake and building of a healthy lifestyle.Conclusions:The driving factors for postpartum health promotion of gestational diabetic women are complex and diverse. Medical staff should timely grasp the post-natal health promotion status of gestational diabetic women, and promote their self-support and social support.

Objective:To investigate the status of family function and self-management in patients with chronic kidney disease in the early stage, and to analyze the correlation between the two.Methods:From May 2018 to November 2019, 242 early stage patients with chronic kidney disease in the Department of Nephrology of the Second Affiliated Hospital of Guangxi Medical University were selected as the research subjects. The family function assessment scale and self-management scale were used for investigation.Results:The average scores of family function in early stage of chronic kidney disease patients were (2.11±0.37) points, and the average scores of self-management were (2.29±0.63) points; family function was negatively correlated with self-management ( r value was -0.832, P <0.05). Multiple linear regression analysis showed that education level and family function were influencing factors of patient self-management ( t value was 15.916, 17.569, P <0.05). Conclusions:The family function and self-management of patients with chronic kidney disease need to be improved in the early stage. Family function can affect patients' self-management. Nursing staff should focus on the functions of communication and behavior control in the family functions of patients with early chronic kidney disease in order to improve their self-management ability.