Objective:To explore the correlation between serum carbohydrate antigen 72-4 (CA72-4) level and pathological differentiation degree of gastric cancer, and to provide reference for early diagnosis, prognosis evaluation and efficacy monitoring of gastric cancer.Methods:A retrospective study was conducted on 136 patients with gastric cancer admitted to Zhejiang Provincial People′s Hospital from April 2022 to December 2024. According to postoperative pathological diagnosis, patients were divided into well-differentiated group ( n=9), moderately differentiated group ( n=36) and poorly/undifferentiated group ( n=91). Preoperative CA72-4 levels and clinical characteristics of patients were collected to analyze the relationship between differentiation degree and CA72-4 level, and to compare the changes of CA72-4 before and after surgery in gastric cancer patients with different differentiation degrees. Results:The preoperative CA72-4 level in the poorly/undifferentiated group was significantly higher than that in the well-differentiated group and moderately differentiated group (all P<0.001). Preoperative CA72-4 level in gastric cancer patients was weakly negatively correlated with differentiation degree ( R=-0.341). After surgery, the CA72-4 level in the poorly/undifferentiated group decreased significantly compared with that before surgery ( P=0.043), while the changes in the well-differentiated group and moderately differentiated group were not significant. Conclusions:There are significant differences in CA72-4 levels among gastric cancer groups with different differentiation degrees. Preoperative CA72-4, as a tumor marker, is of great significance for early diagnosis, prognosis evaluation and postoperative monitoring of gastric cancer. Especially in patients with poorly/undifferentiated gastric cancer, the CA72-4 level is relatively high, which can be used for auxiliary diagnosis and formulation of treatment plans.

Objective:To explore the correlation between serum carbohydrate antigen 72-4 (CA72-4) level and pathological differentiation degree of gastric cancer, and to provide reference for early diagnosis, prognosis evaluation and efficacy monitoring of gastric cancer.Methods:A retrospective study was conducted on 136 patients with gastric cancer admitted to Zhejiang Provincial People′s Hospital from April 2022 to December 2024. According to postoperative pathological diagnosis, patients were divided into well-differentiated group ( n=9), moderately differentiated group ( n=36) and poorly/undifferentiated group ( n=91). Preoperative CA72-4 levels and clinical characteristics of patients were collected to analyze the relationship between differentiation degree and CA72-4 level, and to compare the changes of CA72-4 before and after surgery in gastric cancer patients with different differentiation degrees. Results:The preoperative CA72-4 level in the poorly/undifferentiated group was significantly higher than that in the well-differentiated group and moderately differentiated group (all P<0.001). Preoperative CA72-4 level in gastric cancer patients was weakly negatively correlated with differentiation degree ( R=-0.341). After surgery, the CA72-4 level in the poorly/undifferentiated group decreased significantly compared with that before surgery ( P=0.043), while the changes in the well-differentiated group and moderately differentiated group were not significant. Conclusions:There are significant differences in CA72-4 levels among gastric cancer groups with different differentiation degrees. Preoperative CA72-4, as a tumor marker, is of great significance for early diagnosis, prognosis evaluation and postoperative monitoring of gastric cancer. Especially in patients with poorly/undifferentiated gastric cancer, the CA72-4 level is relatively high, which can be used for auxiliary diagnosis and formulation of treatment plans.

Objective:To explore the real experience of parents caring for children with Kawasaki disease complicated with giant coronary artery aneurysm at home,in order to provide reference for targeted interventions.Methods:With phenomenological approaches in qualitative study,semi-structured interviews were conducted among 10 parents whose children with Kawasaki disease complicated with giant coronary artery aneurysm, and Colaizzi 's 7-step analysis method was used to analyze the data and extract the theme.Results:The care experience of parents were classified into four themes:continued negative emotions;lacked of family care knowledge;bore a huge burden of care; eager for support strength.Conclusions:Parents of children with Kawasaki disease complicated with giant coronary artery aneurysm have many difficulties in disease management,family care and other aspects in the process of caring for children.They also bear a greater burden of psychological pressure.Medical workers should pay attention to parent′s psychological status and related problems,and provide effective intervention measures to promote the rehabilitation of children and improve the quality of life of the family.

Objective To explore the effect of the combination of Internet +and medical care in the compliance of the discharged children with Kawasaki disease. Methods A total of 76 children with Kawasaki disease who were discharged from a third-grade hospital were selected. The control group (37 cases) and the intervention group (39 cases) were selected by random sampling at different time intervals. Both groups received routine guidance during hospitalization. The intervention group was admitted to the WeChat work platform (WeChat group, WeChat public number) and"Almond"doctors' follow-up platform. Six months after discharge, the Kawasaki disease basic knowledge questionnaire was used and the medication compliance (Morisky medication compliance scale) was used for investigation and evaluation. Results The score of the Kawasaki disease basic knowledge questionnaire was (53.38±13.66) points in the control group, and (62.36± 13.48) points in the intervention group, there was significant difference (t=-3.388, P<0.05).The score of Morisky medication compliance scale was (5.97 ± 0.94) points in the control group, and (6.53 ± 1.40) points in the intervention group, and there was significant difference (t=-2.112, P<0.05). Conclusions The integration ofInternet+and medical care can improve the compliance of the parents of children with Kawasaki disease, and can be used in the continuous nursing of children with chronic disease.

Objective: To investigate the status of uncertainty in illness and its influencing factors among parents of children with Kawasaki disease complicated by coronary artery aneurysm. Methods: A total of 102 parents of children with Kawasaki disease complicated by coronary artery aneurysms were investigated by General Information Questionnaire, Parent's Perception of Uncertainty Scale, Hospital Anxiety and Depression Scale. Results: The total sore of Parent′s Perception of Uncertainty Scale was (91.02 ± 13.14) points; that of anxiety was (14.35 ± 3.93) points; while that of depression was (13.81 ± 3.92) points. The uncertainty in illness among parents was influenced by coronary artery aneurysm grading, source of medical expenses, education level, understanding of the disease, average family income (F=2.535-8.740, all P<0.05), relationship with the child, work status (t =2.057, -2.489, P<0.05). Multiple stepwise regression analysis showed that depression, understanding of the disease, source of medical expenses had a significant impact on the illness uncertainty of parents (F=13.695, P<0.05). Conclusions The uncertainty in illness among parents of children with Kawasaki disease complicated by coronary artery aneurysm had a higher level. The doctors and nurses should pay attention to the effect of uncertainty in illness on the parents of children and take targeted intervention measures to help parents reduce uncertainty in illness, thereby improving the quality of life.

Humans ; Severe Acute Respiratory Syndrome ; diagnosis ; therapy