Objective: To evaluate the effect of biofeedback training on bowl function among rectal cancer patients with chemoradiotherapy and temporary enterostomy. Methods: Using randomized controlled trial design, 109 rectal cancer patients were randomly divided into three groups, the first blank control group, the second group pelvic floor muscle exercise group, the third group biofeedback group. High resolution anorectal manometry was used for 6 longitudinal traces in 16 months. Data of bowel function were collected by Memorial Sloan Kettering Cancer Center (MSKCC) Bowel Function Instrument. Results: The main effect of the change of five indicators, anal resting pressure, rectal resting pressure, maximum squeeze pressure, maximum squeeze time and high pressure zone, was time. The other four indicators, rectal volume at first senory, rectal volume at sense of convenience, maximal tolerable rectal volume and rectal compliance, among patients of biofeedback group were (32.71±5.00) ml, (74.26±8.30) ml, (188.40±12.68) ml, (5.69±1.18) ml/kPa and (68.09±6.38). The rectal volume at first senory, rectal volume at sense of convenience, maximal tolerable rectal volume and rectal compliance, among patients of biofeedback group were significant higher than blank control group and pelvic floor muscle exercise group (F=3.589-26.826, P<0.05). Conclusion The biofeedback could significantly improve the sensory indicators of patients with middle and low rectal cancer. High-resolution anorectal manometry could effectively evaluate the effect of biofeedback training in patients with middle and low rectal cancer.

Objective To explore the effect of ultra early hyperbaric oxygen (HBO) treatment on the permeability of blood-brain barrier in persistent cerebral ischemic rats.Methods 66 healthy SD rats were randomly divided into 11 groups:i.e.the sham surgical group,the cerebral ischemia for 2,4,6,12,24 hours groups and the HBO treatment for 2,4,6,12,24 hours groups,each consisting of 6 rats.The rat model of middle cerebral artery occlusion (MCAO) was developed in the rats of the cerebral ischemia groups and the HBO groups by Longa suture method.Ten minutes after development of the model,the rats in the HBO groups received HBO treatment at a pressure of 0.2 MPa (2.0 ATA) for one hour.The severity of blood-brain barrier damage in the rats of the groups was measured by Evans blue extravagating experiment.Results The permeability of blood-brain barrier reached peak at hour 4 in the rats of the cerebral ischemia group (6.15 ± 1.81).As compared with that of the cerebral ischemia group(6.15 ± 1.81,4.64 ±0.71),the permeability of blood-brain barrier in the rats of the HBO group(3.84 ± 1.26,3.27 ± 0.28) decreased most significantly at hour 4 and hour 12,and there was statistical significance when comparisons were made between the groups(P ＜0.05).Conclusion Ultra early HBO treatment could reduce the permeability of Evans blue extravasation in the brain tissue of the rats with persistent cerebral ischemia,improve blood-brain barrier permeability and protect the blood-brain barrier.The permeability decreased most significantly in the cerebral ischemia rats at hour 4 and hour 12.

Objective To explore the effect of ultra early hyperbaric oxygen (HBO) treatment on the permeability of blood-brain barrier in persistent cerebral ischemic rats.Methods 66 healthy SD rats were randomly divided into 11 groups:i.e.the sham surgical group,the cerebral ischemia for 2,4,6,12,24 hours groups and the HBO treatment for 2,4,6,12,24 hours groups,each consisting of 6 rats.The rat model of middle cerebral artery occlusion (MCAO) was developed in the rats of the cerebral ischemia groups and the HBO groups by Longa suture method.Ten minutes after development of the model,the rats in the HBO groups received HBO treatment at a pressure of 0.2 MPa (2.0 ATA) for one hour.The severity of blood-brain barrier damage in the rats of the groups was measured by Evans blue extravagating experiment.Results The permeability of blood-brain barrier reached peak at hour 4 in the rats of the cerebral ischemia group (6.15 ± 1.81).As compared with that of the cerebral ischemia group(6.15 ± 1.81,4.64 ±0.71),the permeability of blood-brain barrier in the rats of the HBO group(3.84 ± 1.26,3.27 ± 0.28) decreased most significantly at hour 4 and hour 12,and there was statistical significance when comparisons were made between the groups(P ＜0.05).Conclusion Ultra early HBO treatment could reduce the permeability of Evans blue extravasation in the brain tissue of the rats with persistent cerebral ischemia,improve blood-brain barrier permeability and protect the blood-brain barrier.The permeability decreased most significantly in the cerebral ischemia rats at hour 4 and hour 12.

Objective To observe the effect of 1 Hz repetitive transcranial magnetic stimulation (rTMS) on upper limb motor function after stroke. Methods 40 patients with ischemic internal carotid artery (ICA) stroke were randomly divided into treatment group (n=20) and control group (n=20). Both groups received conventional rehabilitation and medication. The treatment group received rTMS while the control group received pseudo stimulation, 1 Hz at 100% resting motor threshold (RMT) over contralesional motor cortex (unaffected side). The treatment group was tested with motor evoked potentials (MEPs), and both groups were assessed with Fugl-Meyer Assessment (FMA) and grip strength after treatment. Results The amplitude of MEPs of the unaffected cortex increased in the treatment group after treatment (P< 0.001). The treatment group improved in grip strength and the scores of FMA in the affected side compared with the control group after treatment (P<0.001). No serious side-effect was found. Conclusion rTMS was safe and feasible for patients with ischemic ICA stroke to improve the upper limb motor function.

Objective To investigate the effect and mechanism of ultrashortwave(USW)diathermy and rotating magnetic(RM)field therapy on the brain following transient focal cerebral ischemia and reperfusion in rats. Methods Fifty-two Wistar rats were randomly divided into a sham operation group, an ischemia and a reperfusion control group, a USW treatment group and a RM treatment group. Focal cerebral ischemia and reperfusion were induced by intraluminal filament occlusion of the middle cerebral artery. Each brain was removed at 24 h after the reperfusion and water content, cerebral infarct volume and histological expression of Bcl-2 and Bax proteins were observed. Results When USW treatment was started at 18 h after reperfusion, decreased infarct volume and water content were observed, but RM treatment did not show this relationship. Both USW and RM were associated with increased expression of Bcl-2 protein and decreased the expression of Bax protein. Conclusions USW treatment is beneficial in focal cerebral ischemia. RM′s effect is uncertain. Any effect is through reducing apoptosis.