Objective:To systematically evaluate the impact of maternal arsenic exposure during pregnancy on newborn birth indicators.Methods:Relevant literature on maternal arsenic exposure during pregnancy and newborn birth indicators published domestically and internationally were included in the study by searching databases such as CNKI, WanFang Data, VIP, PubMed, Web of Science, Embase, etc., the search was conducted from the establishment of the database until August 31, 2022. Meta-analysis of effect values was performed using Stata SE16 software, and heterogeneity was tested using I2 statistics and Q-test. Random effects model or a fixed effects model was selected for comprehensive quantitative analysis based on the test results, and regression coefficient (β) was used as the effect indicator. Subgroup analysis was conducted according to the sample type, study area, study type. Results:A total of 34 articles (a total of 57 530 pairs of maternal infant combinations) were included, including 2 Chinese articles and 32 English articles. Among them, there were 31, 16, 18, and 5 articles including maternal arsenic exposure during pregnancy and newborn birth weight, length, head circumference, and chest circumference, respectively. After heterogeneity testing, I2 were 81.1%, 97.1%, 62.8%, and 98.3%, respectively. I2 was ≥50% and P < 0.05, indicating significant heterogeneity. A random effects model was used for meta-analysis. The combined β values (95% CI) of birth weight, length, head circumference, and chest circumference were - 10.99 (- 15.60, - 6.39), - 0.02 ( - 0.10, 0.06), - 0.01 (- 0.04, 0.03), and - 0.18 (- 0.35, - 0.01), respectively. The results of subgroup analysis showed that maternal arsenic exposure during pregnancy had a significant impact on newborn birth weight when the sample type was the blood sample [β(95% CI): - 25.72 (- 44.46, - 6.98)]. Conclusions:Maternal arsenic exposure during pregnancy may cause a relative decrease in newborn birth indicators, especially a significant decrease in birth weight. Blood arsenic level may be an important indicator for evaluating the decrease in birth indicators caused by maternal arsenic exposure during pregnancy.

BACKGROUND:Lung cancer is one of the most common malignant tumors with the worst prognosis worldwide.Its incidence rate and mortality rate have long been among the top of malignant tumors.The heterogeneity and drug resistance are among the reasons contributing to its poor prognosis.Lung cancer organoid,which is a 3D in vitro model cultured from patient-derived tumor cells recapitulating the biological characteristics of the primary tumor,can be used for various researches of lung cancer. OBJECTIVE:To review the application and research progress of lung cancer organoids in chemotherapy,targeted therapy,and immunotherapy drug sensitivity screening,analyze its limitations,aiming to provide new strategies for personalized and precision medicine of lung cancer. METHODS:The first author searched relevant articles published from 2013 to 2023 in CNKI and PubMed in July 2023.The search terms were"organoid,lung cancer organoid,lung cancer experimental model,precision medicine,drug sensitivity test,chemotherapy,targeted therapy,immunotherapy"in Chinese and English.Finally,a total of 84 articles were incorporated. RESULTS AND CONCLUSION:(1)Compared with traditional lung cancer research models,which can only demonstrate two-dimensional cell activities,lack cell-to-cell interactions,and suffer from species differences,lung cancer organoids offer a diverse cell source and continuously optimized culture conditions.They can simulate cellular interactions in a three-dimensional context while retaining the biological characteristics of the original tumor.These organoids represent a promising research model with significant potential,providing a solid foundation for their use in cancer drug screening.(2)Lung cancer organoids have shown preliminary significance in guiding anticancer drug selection.Their predictive outcomes align closely with actual clinical outcomes,marking a pivotal step towards precision in lung cancer treatment.By assessing the efficacy of common chemotherapy,targeted therapy,and immunotherapy drugs,these organoids enable the customization of individualized treatment strategies,reducing unnecessary drug trials and toxic and side reaction while exploring possible alternative drugs or combination regimens for drug resistance issues so as to guide the precision treatment of rare mutated lung cancer and fill the clinical gap.A more comprehensive drug evaluation is provided by comparing the activity of different drugs.Additionally,it is essential to consider the internal heterogeneity of organoids,emphasizing the importance of multiple sampling to enhance result accuracy.(3)Lung cancer organoids have limitations in practical applications such as inconsistent success rates and purity in cultivation and the lack of vascular tissue.To address these shortcomings,improvements are needed in cultivation conditions,expedited testing processes,and the development of multi-organ systems to simulate the overall effects of drugs in multiple organs.These enhancements will contribute to a more accurate assessment of drug efficacy and toxicity,thereby enhancing the precision of lung cancer treatment.

Diabetes, hypertension, and dyslipidemia, collectively referred to the " Three Highs, " represent increasingly prevalent metabolic risk factors in China. Many individuals experience all three conditions concurrently, significantly heightening the risk of cardiovascular disease and mortality. Although the National Metabolic Management Center(MMC) has been established for over eight years and has its unique features, the awareness, treatment, and control rates of these diseases in China remain low, and the efficiency of community management is insufficient. According to the previous two editions of management guidelines and the most recent domestic and international diagnostic and treatment guidelines, this paper conducts an in-depth analysis of the operational experience and management strategies of the MMC. Its aim is to improve the efficiency of grassroots MMC mode management for " Three Highs" patients and ensure that patients receive more standardized management.

Diabetes, hypertension, and dyslipidemia, collectively referred to the " Three Highs, " represent increasingly prevalent metabolic risk factors in China. Many individuals experience all three conditions concurrently, significantly heightening the risk of cardiovascular disease and mortality. Although the National Metabolic Management Center(MMC) has been established for over eight years and has its unique features, the awareness, treatment, and control rates of these diseases in China remain low, and the efficiency of community management is insufficient. According to the previous two editions of management guidelines and the most recent domestic and international diagnostic and treatment guidelines, this paper conducts an in-depth analysis of the operational experience and management strategies of the MMC. Its aim is to improve the efficiency of grassroots MMC mode management for " Three Highs" patients and ensure that patients receive more standardized management.

Objective To analyze the clinical situation and related factors of subclinical hypothyroidism in patients with abnormal glucose metabolism, and to provide theoretical basis for the prevention and treatment of subclinical hypothyroidism in patients with abnormal glucose metabolism. Methods A total of 428 patients with abnormal glucose metabolism who were treated in the Department of Endocrinology of Tianmen First People's Hospital from March 2018 to March 2020 were selected, and serum FT3, FT4 and TSH levels were determined by automatic immune analysis system. Automatic analyzer was used to measure the levels of FBG, HbA1c, TC, TG, LDL-C and UA. A self-made questionnaire was used to investigate the basic information of all subjects, including gender, age, abnormal course of glucose metabolism, BMI and blood pressure. The survey method was combined with telephone inquiry and field investigation. Logistic regression was used to analyze the independent risk factors for subhypothyroidism in patients with abnormal glucose metabolism. Results Among 428 patients with abnormal glucose metabolism, 89 patients were accompanied by subclinical hypothyroidism, including 39 males and 43 females, with an average age of (45.12±8.13) years. The prevalence of subhypothyroidism in females was higher than that in males, and the difference was statistically significant (χ²=4.353 , P<0.05). There was no significant difference in serum FT3 and FT4 levels between the two groups (P>0.05). The serum TSH level in experimental group was significantly higher than that in control group (P<0.05). Univariate analysis showed statistically significant differences in age, gender, abnormal course of glucose metabolism, BMI, BMI, FBG, HbA1c, UA, TC, LDL-C and SBP between the two groups (P<0.05). Logistic regression analysis showed that old age, high levels of FBG, TC, SBP and UA were independent risk factors for subclinical hypothyroidism in patients with abnormal glucose metabolism (P<0.05). Conclusion The incidence rate of patients with abnormal glucose metabolism complicated with subclinical hypothyroidism is high. The biochemical indexes such as blood glucose, blood lipid, blood pressure and uric acid should be monitored regularly. The early regulation of glucose metabolism disorder is an effective way to prevent and treat subclinical hypothyroidism.

Objective:To explore the nursing cooperation of gonioscope assisted transluminal trabeculectomy (GATT).Methods:From February 2019 to August 2020, preoperative visits, preoperative equipment debugging and surgical instrument preparation were conducted for 30 patients (30 eyes) undergoing GATT for open-angle glaucoma in Zhongshan Ophthalmic Center of Sun Yat-sen University. Nurses closely attended the patients and expertly cooperated with doctors in the intraoperative management of patients. The incidence of complications was observed. The intraocular pressure (IOP) and medication were compared before and after operation.Results:Totally 30 cases (30 eyes) completed the operation successfully without serious complications and nursing adverse events. Twenty-six patients (86.7%) completed 360° total incision, and four patients (13.3%) completed 270° total incision. The mean preoperative IOP was (27.43±6.46) mmHg (1 mmHg= 0.133 kPa), the mean postoperative IOP was (13.67±3.01)mmHg. The difference between preoperative and postoperative IOP and the use of anti-glaucoma drugs were of statistical significance ( t value was 10.67, Z value was 4.18, P<0.05). Conclusions:The implementation of fine nursing for patients with GATT can ensure the smooth operation, reduce the incidence of complications and improve the postoperative rehabilitation effect.