Objective: To explore the association between takeout fast foods and sugar sweetened beverage consumption with co-occurrence of anxiety and depressive symptoms among first year junior high school students in Yunnan Province, so as to provide theoretical basis for the prevention of anxiety and depressive symptoms co-occurrence among adolescents. Methods: A random cluster sampling involving 8 500 first year junior high school students in 11 counties in Yunnan Province was conducted by a questionnaire survey from October to December 2022. The Depression Anxiety Stress Scale-21 (DASS-21) was applied to assess anxiety and depressive symptoms in first year junior high school students. Chi-square test was used to compare the anxiety-depression co-occurrence symptoms of first year junior high school students with different demographic characteristics. The association between takeout fast foods and sugar sweetened beverage consumption with co-occurrence of anxiety and depressive symptoms of adolescents was analyzed by binary Logistic regression models. Results: The detection rate of co-occurrence of anxiety and depression symptoms among first year junior high school students in Yunnan Province was 26.92%. After controlling for demographic variables and other confounders, takeout fast foods and sugar sweetened beverage consumption( OR=1.50, 95%CI =1.27-1.77) was associated with anxiety-depression co-occurrence symptoms among first year junior high school students in Yunnan Province ( P <0.01). Stratified analysis showed that both Han ( OR=1.37, 95%CI =1.07-1.77) and ethnic minorities ( OR=1.60, 95%CI =1.29-2.00) exhibited statistically significant associations between takeout fast foods and sugar sweetened beverage consumption with co-occurrence of anxiety and depressive symptoms(both P <0.05). Conclusions Takeout fast foods and sugar sweetened beverage consumption increases the risk of co-occurrence of anxiety and depressive symptoms among first year junior high school students in Yunnan Province. It is recommended to strengthen guidance on the consumption of such products among junior high school students to prevent co-occurrence of anxiety and depressive symptoms.

Based on the theory of diseased collaterals and the progression pattern of diabetic kidney disease （DKD）， this paper proposes a staged treatment system based on the "three states of kidney collaterals" including collateral distention， collateral bi （痹） and collateral accumulation. In the collateral distention stage， the primary pathogenesis is heat damaging the kidney collaterals and collateral vessel dilation， corresponding to the early state of DKD characterized by hyperfiltration and microalbuminuria； the clearing method is suggested， and Shenling Jiangtang Formula （参苓降糖方） can be used to promote the remission of proteinuria by ameliorating insulin resistance and regulating intestinal microecology. In the collateral bi stage， the core pathogenesis lies in the binding of phlegm and stasis， and the formation of concretions and conglomerations in the kidney collaterals， corresponding to massive proteinuria and the decline of renal function， for which the unblocking method should be taken， using Jinchan Yishen Tongluo Formula （金蝉益肾通络方） and Qingre Xiaozheng Formula （清热消癥方） to alleviate renal pathological damage by regulating the autophagy-lysosome pathway and repairing mitochondrial energy metabolism. The collateral accumulation stage is characterized by the internal retention of turbid toxins and accumulations of concretions in the kidney collaterals， corresponding to renal fibrosis and end-stage renal disease （ESRD）； the dispersion method is suggested， and Yiqi Tongluo Xiezhuo Formula （益气通络泄浊方） and Shenyan Fangshuai Fluid （肾炎防衰液） can be used to inhibit extracellular matrix accumulation and delay the progressive loss of renal function. Collateral deficiency runs through the entire course of the disease and is closely related to cellular senescence and the imbalance of the ubiquitin-proteasome/autophagy system. The concept of the "three states of kidney collaterals" integrates the evolution of traditional Chinese medicine pathogenesis with modern pathological staging， forming a whole-course intervention system of "staging-syndrome differentiation-target-formula"， thereby providing novel insights for prevention and treatment of DKD using integrated traditional Chinese and western medicine.

Dietary therapy represents a promising approach to modulate gut microbiota in patients with inflammatory bowel disease (IBD) and may ameliorate certain neurological conditions through the gut-brain axis. The dietary therapy rich in fatty acids has been demonstrated therapeutic efficacy in both IBD and central nervous system (CNS) disorders, mainly manifested as controlling intestinal and neural inflammation through fatty acids. However, robust clinical evidence regarding the efficacy of dietary therapy against neurological manifestations in IBD remains limited. Therefore, this review summarizes the effects of fatty acid-rich dietary therapy in patients with IBD or CNS disorders, as well as the underlying mechanisms of fatty acids, with the aim of providing a reference for the application of such dietary therapy in IBD patients presenting with concurrent CNS manifestations and the development of treatment protocols.

ObjectiveTo systematically retrieve， analyze， and summarize the basic information and clinical research evidence of Chinese patent medicines （CPMs） for endometriosis via a scoping review method. MethodsCPMs indicated for EM were identified from three major drug lists， CNKI， clinical guidelines， and textbooks. Relevant clinical studies were retrieved from eight Chinese and English databases from inception to April 1， 2025. Key data from included studies were extracted to analyze characteristics of CPMs and their clinical evidence. ResultsA total of 18 CPMs were included， among which those with blood-activating and stasis-resolving effects accounted for the highest proportion. Constituent herbs predominantly exhibited sweet， bitter， and pungent flavors， with tropism to the liver and spleen meridians. Daily treatment costs varied substantially across CPMs. The 438 included studies involved 13 CPMs， among which Guizhi Fuling capsules/pills， Sanjie Zhentong capsules， and Dan'e Fukang soft extract/granules were the most extensively studied. Randomized controlled trials （RCTs） were the predominant study design. The most common comparison was between CPMs combined with Western medicine and Western medicine alone. The largest number of studies reported a sample size of 51-100 cases. The high-frequency outcome indicators covered 10 domains， including clinical response rate， adverse reactions， female hormone levels， serum CA125 levels， and recurrence status. ConclusionMultiple oral CPMs demonstrate efficacy in EM management， yet inadequate safety profiles persist in drug labeling. The annual number of clinical studies on oral CPMs for endometriosis showed an overall increasing trend. However， clinical research has shortcomings including uneven distribution of CPMs， small sample sizes， and suboptimal methodological rigor. Future efforts should focus on updating drug indications and safety information in package inserts， conducting high-quality clinical research， and generating more robust evidence to support the clinical use of oral CPMs for EM.

ObjectiveTo systematically retrieve， analyze， and summarize the basic information and clinical research evidence of Chinese patent medicines （CPMs） for endometriosis via a scoping review method. MethodsCPMs indicated for EM were identified from three major drug lists， CNKI， clinical guidelines， and textbooks. Relevant clinical studies were retrieved from eight Chinese and English databases from inception to April 1， 2025. Key data from included studies were extracted to analyze characteristics of CPMs and their clinical evidence. ResultsA total of 18 CPMs were included， among which those with blood-activating and stasis-resolving effects accounted for the highest proportion. Constituent herbs predominantly exhibited sweet， bitter， and pungent flavors， with tropism to the liver and spleen meridians. Daily treatment costs varied substantially across CPMs. The 438 included studies involved 13 CPMs， among which Guizhi Fuling capsules/pills， Sanjie Zhentong capsules， and Dan'e Fukang soft extract/granules were the most extensively studied. Randomized controlled trials （RCTs） were the predominant study design. The most common comparison was between CPMs combined with Western medicine and Western medicine alone. The largest number of studies reported a sample size of 51-100 cases. The high-frequency outcome indicators covered 10 domains， including clinical response rate， adverse reactions， female hormone levels， serum CA125 levels， and recurrence status. ConclusionMultiple oral CPMs demonstrate efficacy in EM management， yet inadequate safety profiles persist in drug labeling. The annual number of clinical studies on oral CPMs for endometriosis showed an overall increasing trend. However， clinical research has shortcomings including uneven distribution of CPMs， small sample sizes， and suboptimal methodological rigor. Future efforts should focus on updating drug indications and safety information in package inserts， conducting high-quality clinical research， and generating more robust evidence to support the clinical use of oral CPMs for EM.

Objective: To investigate the prevalence of co-occurrence of common diseases among junior high school students in Yunnan Province and to identify latent comorbidity patterns and analyze their associated factors, so as to provide evidence for the comprehensive prevention and control of common diseases among students. Methods: From September to November 2025, a stratified cluster sampling method was employed to survey 71 791 students in grades 7-9 recruited from 258 junior high schools in Yunnan Province. Information on six common diseases, including screening myopia, dental caries, overweight/obesity, malnutrition, elevated blood pressure, and abnormal spinal curvature, was collected through physical examinations and questionnaire surveys, along with data on demographic characteristics, physical activity, and sleep. Latent class analysis (LCA) was used to identify comorbidity patterns of common diseases, and multinomial Logistic regression was performed to analyze the factors associated with each pattern. Results: The detection rates of screening myopia, dental caries, overweight/obesity, elevated blood pressure, malnutrition, and abnormal spinal curvature among junior high school students were 65.2%, 62.1%, 22.4%, 10.9% , 8.2%, and 5.7%, respectively. LCA identified three latent comorbidity patterns of common diseases: a high prevalence screening myopia-dental caries-spinal curvature abnormality pattern (C1, 63.8%), an overweight/obesity elevated blood pressure pattern (C2, 24.1%), and a relatively low burden pattern (C3, 12.0%). With C3 as the reference, multinomial Logistic regression showed that girls were more likely than boys to be assigned to C1 and C2 [ OR (95% CI )=2.12(2.02-2.23), 1.31(1.23-1.38)]; non-Han students were less likely than Han students to belong to C1 and C2 [ OR (95% CI )=0.88(0.83-0.92), 0.81(0.77-0.86)]; students in grades 8 and 9 were more likely than those in grade 7 to belong to C1 and C2, with the highest likelihood observed among grade 9 students [ OR (95% CI )=1.43(1.35-1.52), 1.27(1.19-1.36)]; insufficient sleep was associated with increased odds of belonging to C1 and C2 [ OR (95% CI )=1.15(1.09-1.22), 1.25(1.18-1.33)] (all P <0.05). Compared with students who engaged in outdoor activities during breaks, those who stayed indoors, either inside the teaching building but outside the classroom or inside the classroom, were more likely to belong to C1 [ OR (95% CI )=1.09(1.02-1.16), 1.17(1.09-1.26)] and C2 [ OR (95% CI )=1.13(1.05-1.21), 1.25(1.15-1.35)]; students not living with their parents were less likely to belong to C1 and C2 [ OR (95% CI )=0.83(0.77-0.90), 0.74(0.68-0.81)] (all P <0.05). Conclusions The co-occurrence of common diseases is relatively prominent among junior high school students in Yunnan Province, with distinct latent stratification patterns. Tiered and precise comprehensive interventions should be implemented targeting key populations to promote the prevention and control of common diseases among students.

Objective To investigate the reciprocal relationships between trajectories of depressive symptoms(DS)and cognitive function(CF)and to provide a basis for formulating comprehensive management for depression and cognitive impairment among older adults.Methods Group－based dual trajectory modelling was performed to identify dual trajectories of DS and CF usinglongitudinal data from the Chinese Health and Retirement Longitudinal Study.Results 3076 older adults were included in the analysis.Four trajectories of DS(DS1~DS4)were determined:constantly low(30.7%),mild increasing lightly(46.7%),moderately decreasing(19.0%),and constantly high(3.6%);four trajectories of CF(CF1~CF4):persistently high(8.3%),suboptimal slowly decline(51.8%),middle rapidly decline(33.8%)and low rapidly decline(6.1%).Compared with DS 1,the elderly in DS 2~4 were more likely to experience CF 3 and CF 4.Using CF 1 as a reference,the elderly in CF 2~4 were more likely to follow DS 2~4.Conclusion GBMDT captures the degree of overlap and dynamic developmental associations between developmental trajectories for DS and CF among Chinese elderly.

Objective To investigate the effects of continuous caloric restriction(CCR)and low carbon ketogenic diet(LCK)on glucose and lipid metabolism and cardiopulmonary function in overweight patients with type 2 diabetes mellitus(T2DM).Methods In this study,90 patients with T2DM and overweight who received treatment in our hospital from May 2020 to May 2021 were randomly selected as research objects,and 90 patients were randomly divided into control(Con,n=30)group,CCR group(n=30),and LCK group(n=30).After 3 monthes,the body mass index(BMI),changes of blood glucose,blood lipid,heart function and lung function of the three groups were compared.Results After treatment,the BMI,fasting plasma glucose,2-hour postprandial blood glucose,hemoglobin A1c,fasting insulin,insulin resistance index,total cholesterol,triglycerides,low-density lipoprotein cholesterol,average systolic ejection velocity,shortening rate of left ventricular circumference,vital capacity/weight decreased in turn(P<0.05),high-density lipoprotein cholesterol,fasting C-peptide increased in turn(P<0.05).Compared with Con group,the cardiac ejection time,left ventricular ejection fraction,vital capacity and forced expiratory volume in the first second in CCR and LCK groups increased after treatment(P<0.05),while the average systolic ejection rate,left ventricular circumference shortening rate and vital capacity/weight decreased(P<0.05).Conclusions Both CCR and LCK can improve the cardiopulmonary function of overweight T2DM patients,and LCK can improve BMI and glucose and lipid metabolism more effectively.

Objective:To explore the association between the systemic immune-inflammation index (SII) and obesity metabolic phenotypes, as well as metabolic features in children and adolescents.Methods:A cross-sectional study was conducted using the random cluster sampling method from March 2023 to May 2024. Children and adolescents aged 9-17 years in Guangzhou were surveyed through questionnaires, physical measurements, and blood tests. According to BMI and metabolic status, participants were classified into normal-weight groups [metabolically healthy normal weight (MHNW) and metabolically unhealthy normal weight (MUNW)] and overweight/obese groups [metabolically healthy overweight/obese (MHO/O) and metabolically unhealthy overweight/obese (MUO/O)]. After natural log-transformation of SII values (lnSII), multinomial logistic regression was used to assess the association between SII and obesity metabolic phenotypes, while binary logistic regression was applied to assess the relationship between SII and metabolic phenotypes in the overweight/obese subgroup. Linear regression model and restricted cubic spline (RCS) were employed to examine the relationship between SII and metabolic features among the entire population.Results:A total of 3 749 participants were included. After adjusting for covariates, for every unit increase in lnSII, the risk of MHO/O and MUO/O increased by 93% ( OR=1.93, 95% CI: 1.56-2.40, P<0.001) and 156% ( OR=2.56, 95% CI: 2.02-3.25, P<0.001), respectively. In the overweight/obesity subgroup, for every unit increase in lnSII, the risk of MUO/O increased by 37% ( OR=1.37, 95% CI: 1.01-1.87, P=0.045). Linear regression model and RCS showed that lnSII was positively correlated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) (SBP: β=1.39, 95% CI: 0.67-2.11, P<0.001; DBP: β=1.27, 95% CI: 0.79-1.75, P<0.001). lnSII also had a non-linear relationship with triglyceride ( Pnonlinear=0.032) and high-density lipoprotein cholesterol ( Pnonlinear=0.002). Conclusion:Elevated SII levels are associated with unfavorable obesity metabolic phenotypes, higher blood pressure, and altered lipid profiles in children and adolescents. SII may be a potential driving factor for metabolic heterogeneity in children and adolescents.

Objective:To investigate the attention level of oral medicine residents in standardized training (referred to as residency training) to oral aesthetic information and its influencing factors.Methods:This study was a cross-sectional study, which included 262 residents undergoing standardized training at Hospital of Stomatology, Wuhan University in January 2020. Among them, there were 73 males and 189 females, with an age range of 23-33 (26±2) years. A questionnaire survey method was used, and the questionnaire included the basic characteristics of the subjects (gender, grade, major, identity, and having training experience in prosthodontic base or not) as well as their attention to oral aesthetic information (facial proportions, facial midline, smile line, facial contour, E-line, nasolabial angle, tooth shape and contour, and tooth proportions). Differences in the attention to oral aesthetic information among residents with different basic characteristics were compared, and a multivariable logistic regression was used to identify the influencing factors.Results:Among the 262 oral medicine residents, 256 (97.7%) believed that it was necessary to pay attention to oral aesthetic information. The differences in attention to facial proportions between residents of different genders and between those with and without training experience in the prosthodontic base were statistically significant (both P<0.05). The results of the multivariate logistic regression showed that male residents were less likely to pay attention to facial proportions compared with female residents ( OR=0.45, 95% CI: 0.23-0.88). Compared with residents specializing in orthodontics, non-orthodontic residents were less likely to pay attention to the E-line ( OR=0.14-0.27, 95% CI: 0.04-0.68) and nasolabial angle ( OR=0.14-0.31, 95% CI: 0.04-0.81). Residents who were graduate students with integrated four certificates were more likely to pay attention to the E-line compared with industry-based personnel ( OR=1.88, 95% CI: 1.01-3.49). Residents without training experience in the prosthodontic base were less likely to pay attention to the facial proportion ( OR=0.44, 95% CI: 0.20-0.97) and tooth shape and contour ( OR=0.33, 95% CI: 0.11-0.98) compared with those with such training experience in prosthodontic base. Conclusions:Oral medicine residents have a high level of attention to oral aesthetic information. Gender, major, identity, and having training experience in the prosthodontic base or not are factors that influence their attention to oral aesthetic information.