Objective To analyze the clinical effect of Shufeng Jiedu capsule combined with Budesonide inhalation aerosol on acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 122 AECOPD patients admitted to the 404th Hospital of Mianyang,Sichuan Province from February 2022 to January 2023 were selected and divided into study group(n=61)and control group(n=61)by random number table method.All the patients received standardized basic treatment.The control group was also given Budesonide inhalation aerosol,and the study group was given Shufeng Jiedu capsule plus Budesonide inhalation aerosol.The patients in both groups were treated for 14 d.The clinical efficacy,forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC),serum C-reactive protein(CRP),serum amyloid A(SAA),serum procalcitonin(PCT),airway wall thickness-diameter ratio(TDR),percentage of wall area(WA)and drug safety were compared between the two groups.Results The total effective rate of the study group was significantly higher than that of the control group(93.44%vs.75.41%,P<0.05).After treatment,the levels of FEV1,PEF and FVC were increased in both groups(P<0.05),especially in the study group(P<0.05).After treatment,serum levels of CRP,SAA and PCT,TDR and WA were decreased in both groups(P<0.05),especially in the study group(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Shufeng Jiedu Capsule combined with Budesonide inhalation aerosol is effective,safe and reliable in the treatment of AECOPD.It can improve lung function and airway remodeling indexes,alleviate inflammation and reduce SAA level.